Abstract:
:The major aim of this study is to elucidate the hypocholesterolemic mechanism exerted by rice protein (RP) in adult rats under cholesterol-enriched dietary condition. Compared with casein, the cholesterol levels in plasma and the liver were significantly reduced by RP, accompanying significant inhibition of cholesterol absorption. RP increased the activity and mRNA level of cholesterol 7α-hydroxylase, whereas acyl-CoA:cholesterol acyltransferase activity and gene expression were significantly depressed with consumption of RP. Neither the activity nor gene expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase of RP differed from that of casein. The gene expression of the peroxisome proliferator-activated receptor α and liver X receptor α were significantly activated by consumption of RP. RP did not modify the mRNA level of sterol regulatory element-binding protein-2 with respect to casein. These results suggest RP can induce a cholesterol-lowering effect through modifying cholesterol metabolism-related gene expression and enzyme activity in adult rats.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Yang L,Han G,Liu QH,Wu Q,He HJ,Cheng CZ,Duan YJdoi
10.3109/09637486.2013.804038subject
Has Abstractpub_date
2013-11-01 00:00:00pages
836-42issue
7eissn
0963-7486issn
1465-3478journal_volume
64pub_type
杂志文章abstract::Bulgur has been one of the most important traditional Durum wheat products in Turkey and Middle Eastern countries for ages. The objective of this study was to reveal the composition of some healthy components of industrial bulgur samples produced in Turkey. Total starch, resistant starch, dietary fibre and total pheno...
journal_title:International journal of food sciences and nutrition
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