Abstract：
:The effect of chlorogenic acid-enriched green coffee bean extract (cGCE) intake on arterial stiffness was investigated using the cardio-ankle vascular index (CAVI) as a novel surrogate marker for predicting arteriosclerosis. A placebo-controlled double-blind pilot study was conducted with 16 healthy Japanese men. Subjects were divided into two groups and consumed beverages containing either cGCE or placebo daily for 2 weeks. The CAVI, the primary endpoint of the study, was evaluated at the beginning of the study and 2 weeks later. Endothelium-dependent flow-mediated dilation (FMD) and sympathetic nervous activity (SNA), which are thought to be related to the CAVI, were also measured. The CAVI change was significantly greater in the cGCE group than in the placebo group. In addition, FMD increased and SNA decreased in the cGCE group. These findings suggest that 2-week ingestion of cGCE may improve arterial stiffness as assessed by the CAVI.
journal_name
Int J Food Sci Nutrjournal_title
International journal of food sciences and nutritionauthors
Suzuki A,Nomura T,Jokura H,Kitamura N,Saiki A,Fujii Adoi
10.1080/09637486.2019.1585763subject
Has Abstractpub_date
2019-11-01 00:00:00pages
901-908issue
7eissn
0963-7486issn
1465-3478journal_volume
70pub_type
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