Osteopontin-enriched formula feeding improves the T-cell-dependent humoral immune responses in infant rats.

Abstract:

:Previous studies have shown that osteopontin (OPN) can enhance infant resistance to infection. However, the underlying mechanisms remain to be explored. Here, we studied the effects of OPN on the development and functions of immune cells in infant rats fed with OPN-enriched formula (OF) compared with regular formula (RF). After 21 days feeding, the proportion of infant rats' CD3+ T cells of lymph nodes in the OF group is significantly increased compared with the RF group. The proportion of CD4+ and CD8+ T cells of lymph nodes in the OF group is closer to the breast feeding (BF) group than to the RF group. Upon immunisation with the thymus-dependent antigen ovalbumin (OVA), the concentration of OVA-specific IgG in the OF group was significantly higher than that in the RF group. Altogether OPN-enriched infant formula feeding can promote the differentiation of CD3+ T cells and improve the T-cell-dependent humoral immune responses in infant rats.

journal_name

Int J Food Sci Nutr

authors

Chen X,Fang M,Xing S,Zuo D,Zhang P,Hu Z

doi

10.1080/09637486.2018.1475552

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

969-975

issue

8

eissn

0963-7486

issn

1465-3478

journal_volume

69

pub_type

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