MECHANISMS IN ENDOCRINOLOGY: Brown adipose tissue in humans: regulation and metabolic significance.

abstract：OBJECTIVES:The aim of the present study was to determine vascular endothelial growth factor (VEGF), prostaglandin E(2) (PGE(2)) and active renin levels in patients with hormonally active adrenal tumours. DESIGN:The study was comprised of 16 patients with primary aldosteronism, 13 patients with active Cushing's syndrom...

journal_title：European journal of endocrinology

authors： Zacharieva S,Atanassova I,Orbetzova M,Nachev E,Kalinov K,Kirilov G,Shigarminova R,Ivanova R,Dashev G

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:To test further the hypothesis that autosomal dominant neurohypophyseal diabetes insipidus (adFNDI) is caused by heterozygous mutations in the vasopressin-neurophysin II (AVP-NPII) gene that exert a dominant negative effect by producing a precursor that misfolds, accumulates and eventually destroys the neuros...

journal_title：European journal of endocrinology

authors： Rutishauser J,Kopp P,Gaskill MB,Kotlar TJ,Robertson GL

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:To identify chromosomal gains and losses in sporadic parathyroid adenomas (PAs). METHODS:Fourteen sporadic PAs were studied by comparative genomic hybridization (CGH). RESULTS:The fourteen studied PAs showed chromosomal imbalances. All cases except one exhibited two or more abnormalities. Chromosomal gains ...

journal_title：European journal of endocrinology

authors： Garcia JL,Tardio JC,Gutierrez NC,Gonzalez MB,Polo JR,Hernandez JM,Menarguez J

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their re...

journal_title：European journal of endocrinology

authors： Kamoda T,Saitoh H,Nakahara S,Inudoh M,Hirano T,Matsui A

更新日期：1999-12-01 00:00:00

abstract：OBJECTIVE:Polycystic ovarian syndrome (PCOS) is associated with skeletal muscle insulin resistance (IR), which has been linked to decreased mitochondrial function. We measured mitochondrial respiration in lean and obese women with and without PCOS using high-resolution respirometry. METHODS:Hyperinsulinemic-euglycemic...

journal_title：European journal of endocrinology

authors： Rabøl R,Svendsen PF,Skovbro M,Boushel R,Schjerling P,Nilas L,Madsbad S,Dela F

更新日期：2011-10-01 00:00:00

abstract：:Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned...

journal_title：European journal of endocrinology

authors： Holzenberger M

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:Disturbed renal function may play an important role in the clinico-pathological presentation of primary hyperparathyroidism (pHPT). We studied the influence of renal function on the clinico-pathological characteristics of 141 patients (123 women and 18 men) with surgically proven pHPT. METHODS:The 141 patien...

journal_title：European journal of endocrinology

authors： Yamashita H,Noguchi S,Uchino S,Watanabe S,Murakami T,Ogawa T,Masatsugu T,Takamatsu Y,Miyatake E,Yamashita H

更新日期：2003-06-01 00:00:00

abstract：:Genetic predictors of outcome are reviewed in the context of a disease--cancer--that can be (too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evid...

journal_title：European journal of endocrinology

authors： Tavares C,Melo M,Cameselle-Teijeiro JM,Soares P,Sobrinho-Simões M

更新日期：2016-04-01 00:00:00

abstract：:Dogs kept under controlled photoperiodic conditions of 12 h light and 12 h dark expressed a clear diurnal melatonin rhythm in the peripheral blood, with a swift peak restricted to the late part of the scotophase. The highest density of high-affinity, G-protein-linked 2-[125I]iodomelatonin binding sites was found in th...

journal_title：European journal of endocrinology

authors： Stankov B,Møller M,Lucini V,Capsoni S,Fraschini F

更新日期：1994-08-01 00:00:00

abstract：:The initial management of large non-functioning pituitary adenomas is surgical debulking. In some cases, postoperative radiotherapy (RT) is administered in order to reduce the likelihood of tumour regrowth. Historically, there have been concerns surrounding a number of potentially significant complications of pituitar...

journal_title：European journal of endocrinology

authors： Boelaert K,Gittoes NJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:Hormone treatment is an important part of gender reassignment therapy in gender dysphoria. Previous data about efficacy and safety are commonly based on small cohorts or they comprise former cohorts under meanwhile obsolet therapy regimes. Our objective was to investigate these topics in a large cohort of ind...

journal_title：European journal of endocrinology

authors： Meyer G,Mayer M,Mondorf A,Fluegel AK,Herrmann E,Bojunga J

更新日期：2019-11-01 00:00:00

abstract：Objective:Pancreatic neuroendocrine neoplasms (PanNENs) are rare tumors arising from the endocrine pancreas; however, their prognosis differs significantly upon their proliferative state, which is characterized by histopathological grading. MiRNAs are small, noncoding RNAs posttranscriptionally regulating gene expressi...

journal_title：European journal of endocrinology

authors： Grolmusz VK,Kövesdi A,Borks K,Igaz P,Patócs A

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Survival rates among childhood cancer survivors (CCS) have enormously increased in the last 40 years. However, this improvement has been achieved at the expense of serious late effects that frequently involve the endocrine system. AIM:To evaluate the cumulative incidence of endocrine diseases in a cohort of...

journal_title：European journal of endocrinology

authors： Brignardello E,Felicetti F,Castiglione A,Chiabotto P,Corrias A,Fagioli F,Ciccone G,Boccuzzi G

更新日期：2013-02-20 00:00:00

abstract：OBJECTIVE:To investigate the effects of long-term GH in GH-deficient adults, as predicted by IGF-I levels. METHODS:Patients received GH, 5 microg/kg per day for 1 Month and 10 microg/kg per day for another 12-30 Months. Changes in body composition, cardiac structure/function, serum lipids and quality of life were meas...

journal_title：European journal of endocrinology

authors： Ezzat S,Fear S,Gaillard RC,Gayle C,Marcovitz S,Mattioni T,Nussey S,Rees A,Svanberg E

更新日期：2003-12-01 00:00:00

abstract：:Surgery is the treatment of choice for non-functioning pituitary macroadenomas (NFPAs). In cases of postoperative remnant growth or tumor recurrence, radiotherapy (RT) can be considered. The role of RT in the postoperative management of NFPAs is still debated. The main arguments against routine use of RT are the lack ...

journal_title：European journal of endocrinology

authors： Chanson P,Dormoy A,Dekkers OM

更新日期：2019-07-01 00:00:00

abstract：:The objective of the present study was to compare fasting levels of free IGF-I in serum from patients with adult onset growth hormone deficiency (GHD) and from healthy volunteers, and to examine the effect of GH replacement therapy in GHD on serum free IGF-I. Free IGF-I was measured using separation of free IGF-I by u...

journal_title：European journal of endocrinology

authors： Skjaerbaek C,Vahl N,Frystyk J,Hansen TB,Jørgensen JO,Hagen C,Christiansen JS,Orskov H

更新日期：1997-08-01 00:00:00

abstract：:Stem cell terminology has entered the lexicon of medical practitioners even though the application of harvesting stem cells to treat diseases other than haematological disorders is not yet a reality in clinical practice. All branches of medicine will be affected by the new technology, more so those related to regenera...

journal_title：European journal of endocrinology

authors： Hughes IA

更新日期：2004-11-01 00:00:00

abstract：Objective:Children with Prader-Willi syndrome (PWS) have mild to moderate cognitive impairment. Short-term studies showed positive effects of growth hormone (GH) on cognitive development. This study investigated the effects of 8 years of GH on cognitive development in children with PWS. We also investigated whether sta...

journal_title：European journal of endocrinology

authors： Donze SH,Damen L,Mahabier EF,Hokken-Koelega ACS

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Primary aldosteronism (PA) has deleterious effects on kidney function independent of blood pressure levels. Up to now, data on effectiveness of different PA therapies regarding renal function are scarce. DESIGN AND METHODS:This prospective multi-center study included 29 patients with newly diagnosed PA evalu...

journal_title：European journal of endocrinology

authors： Fourkiotis V,Vonend O,Diederich S,Fischer E,Lang K,Endres S,Beuschlein F,Willenberg HS,Rump LC,Allolio B,Reincke M,Quinkler M,Mephisto Study Group.

更新日期：2012-12-10 00:00:00

abstract：OBJECTIVE:Local 5'-deiodination of l-thyroxine (T(4)) to active thyroid hormone 3,3',5-tri-iodothyronine (T(3)) catalyzed by the two 5'-deiodinase enzymes (D1 and D2) regulates various T(3)-dependent functions in the anterior pituitary and has been well studied in rodents. Only limited information about deiodinase expr...

journal_title：European journal of endocrinology

authors： Baur A,Buchfelder M,Köhrle J

更新日期：2002-08-01 00:00:00

abstract：:Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Palù G,Boscaro M

更新日期：2000-10-01 00:00:00

abstract：:Major hormonal changes emerge during pregnancy. The pituitary gland is one of the most affected organs with altered anatomy and physiology. The pituitary gland is enlarged as a result of lactotroph hyperplasia. Due to physiological changes in the pituitary and target hormone levels, binding globulins, and placental ho...

journal_title：European journal of endocrinology

authors： Karaca Z,Tanriverdi F,Unluhizarci K,Kelestimur F

更新日期：2010-03-01 00:00:00

abstract：:Tall stature is defined as a height of more than 2 standard deviations (s.d.) above average for same sex and age. Tall individuals are usually referred to endocrinologists so that hormonal disorders leading to abnormal growth are excluded. However, the majority of these patients have familial tall stature or constitut...

journal_title：European journal of endocrinology

authors： Albuquerque EVA,Scalco RC,Jorge AAL

更新日期：2017-06-01 00:00:00

abstract：:In non-functioning pituitary macroadenoma (NFMA), hyperprolactinaemia (hyperPRL) is considered to be a sign of hypothalamic-pituitary dysregulation, but it is unknown whether hyperPRL is associated with an increased frequency of pituitary hormone deficiencies. Forty consecutive patients with histology-proven NFMA were...

journal_title：European journal of endocrinology

authors： Tjeerdsma G,Sluiter WJ,Hew JM,Molenaar WM,de Lange WE,Dullaart RP

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. DESIGN:Observati...

journal_title：European journal of endocrinology

authors： Voorhoeve PG,van Rossum EF,Te Velde SJ,Koper JW,Kemper HC,Lamberts SW,de Waal HA

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:In hyperthyroidism, tissue glucose disposal is increased to adapt to high energy demand. Our aim was to examine the regulation of glucose transporter (GLUT) isoforms by IGF-I in monocytes from patients with hyperthyroidism. DESIGN AND METHODS:Blood (20 ml) was drawn from 21 healthy and 10 hyperthyroid subjec...

journal_title：European journal of endocrinology

authors： Dimitriadis G,Maratou E,Boutati E,Kollias A,Tsegka K,Alevizaki M,Peppa M,Raptis SA,Hadjidakis DJ

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction predicts poorer health outcomes, but the relationship between thyroid hormone levels within the reference range and mortality in older adults remains unclear. In this study, we examined the associations between the concentrations of free thyroxine (FT4) and TSH and all-cause mortality in o...

journal_title：European journal of endocrinology

authors： Yeap BB,Alfonso H,Hankey GJ,Flicker L,Golledge J,Norman PE,Chubb SA

更新日期：2013-09-12 00:00:00

abstract：OBJECTIVE:To determine if human growth hormone (hGH) replacement therapy alters pharmacokinetics of hydrocortisone (CS) substitution in hypopituitary adults. DESIGN:To this aim, we analysed serum and salivary CS profiles 270 min after oral CS administration at baseline and 6 and 12 months after initiation of hGH repla...

journal_title：European journal of endocrinology

authors： Tschöp M,Lahner H,Feldmeier H,Grasberger H,Morrison KM,Janssen OE,Attanasio AF,Strasburger CJ

更新日期：2000-12-01 00:00:00

abstract：:We here investigate the potential rescue of the relative hyposomatotropism of aging and obesity by 3-day pulsatile GHRH infusions (i.v. bolus 0.33 microg/kg every 90 min) in 19 healthy men of varying ages (18 to 66 years) and body compositions (12 to 37% total body fat). Baseline (control) and GHRH-driven pulsatile GH...

journal_title：European journal of endocrinology

authors： Iranmanesh A,South S,Liem AY,Clemmons D,Thorner MO,Weltman A,Veldhuis JD

更新日期：1998-07-01 00:00:00