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Prevention of Serpin Misfolding by RNA Aptamers.

Abstract：

:Owing to their structural flexibility, most serpins inhibit the cognate proteases in a fast and specific manner and also are susceptible to pathogenic misfolding. In this issue of Cell Chemical Biology, Madsen et al. (2016) report on the selection and characterization of an RNA aptamer that stabilizes α1-antichymotrypsin L55P mutant without interfering with the protease inhibitory activity.

journal_name

Cell Chem Biol

journal_title

Cell chemical biology

authors

Zhou X,Declerck PJ

doi

10.1016/j.chembiol.2016.06.002

subject

Has Abstract

pub_date

2016-06-23 00:00:00

pages

639-40

issue

6

eissn

2451-9456

issn

2451-9448

pii

S2451-9456(16)30169-6

journal_volume

23

pub_type

评论,杂志文章

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