Principles of Chemical Biology: Iron and CSCs, Histone Acylation sans Enzymes, Eliciting Silent Gene Clusters, and 2'-deoxy-ADPR as a Second Messenger.

Abstract:

:This month: Lysosomal iron linked to cell death in cancer stem cells, non-enzymatic catalyst SynCAc for histone acylation, cytotoxins ivermectin and etoposide bring new anti-fungals out of the crypt, and 2'-deoxy-ADPR as second messenger activating TRPM2.

journal_name

Cell Chem Biol

journal_title

Cell chemical biology

authors

doi

10.1016/j.chembiol.2017.07.016

subject

Has Abstract

pub_date

2017-08-17 00:00:00

pages

919-920

issue

8

eissn

2451-9456

issn

2451-9448

pii

S2451-9456(17)30274-X

journal_volume

24

pub_type

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    authors: Liu X,Baarsma HA,Thiam CH,Montrone C,Brauner B,Fobo G,Heier JS,Duscha S,Königshoff M,Angeli V,Ruepp A,Campillos M

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    authors: Lee MH,Nuccio SP,Raffatellu M

    更新日期:2020-07-16 00:00:00

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    journal_title:Cell chemical biology

    pub_type: 杂志文章

    doi:10.1016/j.chembiol.2018.11.008

    authors: Hansen SR,Nikolai BJ,Spreacker PJ,Carrocci TJ,Hoskins AA

    更新日期:2019-03-21 00:00:00

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    abstract::Despite the urgent need for assays to visualize insulin secretion there is to date no reliable method available for measuring insulin release from single cells. To address this need, we developed a genetically encoded reporter termed RINS1 based on proinsulin superfolder GFP (sfGFP) and mCherry fusions for monitoring ...

    journal_title:Cell chemical biology

    pub_type: 杂志文章

    doi:10.1016/j.chembiol.2017.03.001

    authors: Schifferer M,Yushchenko DA,Stein F,Bolbat A,Schultz C

    更新日期:2017-04-20 00:00:00

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    abstract::Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this comple...

    journal_title:Cell chemical biology

    pub_type: 杂志文章

    doi:10.1016/j.chembiol.2019.03.003

    authors: Clister T,Greenwald EC,Baillie GS,Zhang J

    更新日期:2019-06-20 00:00:00

  • Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites.

    abstract::There is a scarcity of pharmacological tools to interrogate protein kinase function in Plasmodium parasites, the causative agent of malaria. Among Plasmodium's protein kinases, those characterized as atypical represent attractive drug targets as they lack sequence similarity to human proteins. Here, we describe takini...

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    pub_type: 杂志文章

    doi:10.1016/j.chembiol.2018.11.003

    authors: Raphemot R,Eubanks AL,Toro-Moreno M,Geiger RA,Hughes PF,Lu KY,Haystead TAJ,Derbyshire ER

    更新日期:2019-03-21 00:00:00

  • More than One Way to Skin a Catalyst.

    abstract::In this issue of Cell Chemical Biology, Diaz et al. (2017) report a strategy to achieve temporal, spatial, and stoichiometric control over the protein kinase cAbl in living cells. They achieve this by splitting cAbl into two inactive fragments that form an active kinase upon small molecule addition, potentially provid...

    journal_title:Cell chemical biology

    pub_type: 杂志文章

    doi:10.1016/j.chembiol.2017.10.004

    authors: Michnick SW

    更新日期:2017-10-19 00:00:00