Abstract：
:The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and to protect cells against a wide range of pro-oxidative insults. As NAC itself is a poor scavenger of oxidants, the molecular mechanisms behind the antioxidative effects of NAC have remained uncertain. Here we show that NAC-derived cysteine is desulfurated to generate hydrogen sulfide, which in turn is oxidized to sulfane sulfur species, predominantly within mitochondria. We provide evidence suggesting the possibility that sulfane sulfur species produced by 3-mercaptopyruvate sulfurtransferase and sulfide:quinone oxidoreductase are the actual mediators of the immediate antioxidative and cytoprotective effects provided by NAC.
journal_name
Cell Chem Bioljournal_title
Cell chemical biologyauthors
Ezeriņa D,Takano Y,Hanaoka K,Urano Y,Dick TPdoi
10.1016/j.chembiol.2018.01.011subject
Has Abstractpub_date
2018-04-19 00:00:00pages
447-459.e4issue
4eissn
2451-9456issn
2451-9448pii
S2451-9456(18)30033-3journal_volume
25pub_type
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