当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL NUTRITION期刊下所有文献 > Vitamin B12, homocysteine and depressive symptoms: a longitudinal study among older adults.

Vitamin B12, homocysteine and depressive symptoms: a longitudinal study among older adults.

Abstract：

BACKGROUND/OBJECTIVES:The roles of vitamin B12 and homocysteine concentration in depression are not clear. We investigated cross-sectional and prospective associations of serum vitamin B12 and plasma homocysteine with depressive symptoms in Dutch older adults. SUBJECTS/METHODS:In the Longitudinal Aging Study Amsterdam (LASA), blood was collected in 1995/1996 among 1352 men and women aged ⩾65 years. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) six times from 1995/1996 to 2011/2012. Multiple linear regression and mixed models were used to assess whether vitamin B12 and homocysteine were associated with severity at baseline and course of depressive symptoms over 16 years. Cox regression analyses were performed for the associations with incidence of depression (CES-D ⩾16 and/or antidepressant use). All analyses were adjusted for sociodemographic characteristics and lifestyle factors. RESULTS:Vitamin B12 was neither cross-sectionally (n=1205) nor prospectively (n=1012) associated with depressive symptoms (adjusted β for CES-D over time, lowest versus highest quartile: -0.04 (95% confidence interval (CI): -0.15-0.06)). We also found no association with incident depression (n=853), except for a higher risk of depression over time in younger participants (aged 64.8-73.4 years; continuous vitamin B12, adjusted hazard ratio per s.d.: 1.38 (95% CI: 1.10-1.72)). For homocysteine, no associations were found, except for a lower risk of depression in younger participants. CONCLUSIONS:Our study did not confirm earlier shown associations of serum vitamin B12 and plasma homocysteine with severity and course of depressive symptoms and incidence of depression in older adults. Further research into the influence of homocysteine metabolism on mental health is needed.

journal_name

Eur J Clin Nutr

journal_title

European journal of clinical nutrition

authors

Elstgeest LE,Brouwer IA,Penninx BW,van Schoor NM,Visser M

doi

10.1038/ejcn.2016.224

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

468-475

issue

4

eissn

0954-3007

issn

1476-5640

pii

ejcn2016224

journal_volume

71

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL NUTRITION文献大全
  • Does vitamin C supplementation influence the levels of circulating oxidized LDL, sICAM-1, sVCAM-1 and vWF-antigen in healthy male smokers?

    abstract：OBJECTIVE:To examine the effects of vitamin C supplementation on the concentration of oxidation markers, in particular, circulating oxidized LDL (OxLDL) and on endothelial activation markers. DESIGN:Randomized double-blind, placebo-controlled crossover trial. SETTING:Belgian population of the city of Leuven. SUBJECT...

    journal_title：European journal of clinical nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.ejcn.1601990

    authors： Van Hoydonck PG,Schouten EG,Manuel-Y-Keenoy B,van Campenhout A,Hoppenbrouwers KP,Temme EH

    更新日期：2004-12-01 00:00:00

  • Intimate partner violence and chronic undernutrition among married Bangladeshi women of reproductive age: are the poor uniquely disadvantaged?

    abstract：BACKGROUND/OBJECTIVES:To investigate (i) associations of intimate partner violence (IPV) and chronic undernutrition among women of reproductive age and (ii) whether women who experience both poverty and IPV are unique in their nutritional disadvantages. SUBJECTS/METHODS:This study used the data from the 2007 Banglades...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2012.202

    authors： Rahman M,Nakamura K,Seino K,Kizuki M

    更新日期：2013-03-01 00:00:00

  • Zinc supplementation: effects on the growth and morbidity of undernourished Jamaican children.

    abstract：OBJECTIVE:We investigated whether there was a growth or morbidity response to zinc supplementation. DESIGN:The study was randomized, placebo-controlled, and double-blind. SETTING:Children were recruited at clinics in Kingston, Jamaica, and supplemented at home. SUBJECTS:Children selected were singletons aged 6-24 mo...

    journal_title：European journal of clinical nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.ejcn.1600509

    authors： Meeks Gardner J,Witter MM,Ramdath DD

    更新日期：1998-01-01 00:00:00

  • Is waist circumference per body mass index rising differentially across the United States, England, China and Mexico?

    abstract：BACKGROUND/OBJECTIVES:Little is known about whether waist circumference (WC) has increased disproportionately relative to body mass index (BMI) around the world. SUBJECTS/METHODS:Data came from the US National Health and Nutrition Examination Survey (1988-1994 and 2007-2010), Health Survey for England (1992-1993 and 2...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2015.71

    authors： Albrecht SS,Gordon-Larsen P,Stern D,Popkin BM

    更新日期：2015-12-01 00:00:00

  • Rye bread decreases postprandial insulin response but does not alter glucose response in healthy Finnish subjects.

    abstract：OBJECTIVE:To compare if postprandial glucose and insulin responses to wholekernel rye bread are lower than to wheat bread, and to see if these responses to two types of rye breads are different. To explore starch digestion in more detail, rate of starch hydrolysis of same breads was measured in vitro. DESIGN:Subjects ...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1600716

    authors： Leinonen K,Liukkonen K,Poutanen K,Uusitupa M,Mykkänen H

    更新日期：1999-04-01 00:00:00

  • Relationships between insulin sensitivity, skeletal muscle mass and muscle quality in obese adolescent boys.

    abstract：:We examined the relationships between insulin sensitivity (IS), skeletal muscle (SM) mass and SM quality in youth. Forty obese adolescent boys (body mass index ≥ 95 th percentile, 12-18 years) participated in this study. IS and glucose tolerance was measured by a 3 h hyperinsulinemic-euglycemic clamp and a 2 h oral gl...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2012.142

    authors： Lee S,Kim Y,White DA,Kuk JL,Arslanian S

    更新日期：2012-12-01 00:00:00

  • Effect of camel milk on glycemic control and insulin requirement in patients with type 1 diabetes: 2-years randomized controlled trial.

    abstract：BACKGROUND/OBJECTIVES:Hypoglycemic effect of camel milk supplementation in experimental rat model and significant reduction in doses of insulin in type 1 diabetic patients have been observed in our previous studies. This long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ejcn.2011.98

    authors： Agrawal RP,Jain S,Shah S,Chopra A,Agarwal V

    更新日期：2011-09-01 00:00:00

  • Postprandial thermogenesis in lactating and non-lactating women from The Gambia.

    abstract：:Postprandial thermogenesis was assessed by indirect calorimetry in 32 Gambian women classified into three groups as follows: 12 non-pregnant non-lactating and 10 lactating women studied during the dry season and 10 lactating women studied during the rainy season. The test meal consisted of a typical Gambian breakfast ...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：

    authors： Frigerio C,Schutz Y,Whitehead R,Jéquier E

    更新日期：1992-01-01 00:00:00

  • Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete.

    abstract：BACKGROUND:Studies have shown that depression relates to biomarkers of both short- and long-term polyunsaturated fatty acid (PUFA) intake. However, it is not known which of these two biomarkers has the closest relationship to depression. OBJECTIVE:To examine the relationship of depression with both adipose tissue and ...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1602413

    authors： Mamalakis G,Jansen E,Cremers H,Kiriakakis M,Tsibinos G,Kafatos A

    更新日期：2006-08-01 00:00:00

  • Predictive equations for basal metabolic rates of Indian males.

    abstract：:The article deals with the generation of a prediction equation for basal metabolic rate (BMR) of well-nourished Indian males, from prospective measurements on 121 males, using a single validated technique. The equation related BMR to simple measures such as weight (WT) and age, and was given by: BMR (kJ/d) = 48.7 * WT...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,评审

    doi：

    authors： Soares MJ,Francis DG,Shetty PS

    更新日期：1993-06-01 00:00:00

  • Effect of vitamin C on common cold: randomized controlled trial.

    abstract：OBJECTIVE:To investigate the relationship between the common cold and vitamin C supplementation. DESIGN:A double-blind, 5-year randomized controlled trial. SETTING:A village in Akita prefecture, one of the regions in Japan with the highest mortality from gastric cancer. SUBJECTS:Participants in annual screening prog...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/sj.ejcn.1602261

    authors： Sasazuki S,Sasaki S,Tsubono Y,Okubo S,Hayashi M,Tsugane S

    更新日期：2006-01-01 00:00:00

  • Impact of baseline vitamin B12 status on the effect of vitamin B12 supplementation on neurologic function in older people: secondary analysis of data from the OPEN randomised controlled trial.

    abstract：BACKGROUND/OBJECTIVES:The available evidence from randomised controlled trials suggests that vitamin B12 supplementation does not improve neurologic function in older people with marginal but not deficient Vitamin B12 status. This secondary analysis used data from the Older People and Enhanced Neurological function (OP...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/ejcn.2017.7

    authors： Miles LM,Allen E,Clarke R,Mills K,Uauy R,Dangour AD

    更新日期：2017-10-01 00:00:00

  • Association between antioxidant nutritional indicators and the incidence of dementia: results from the PAQUID prospective cohort study.

    abstract：OBJECTIVE:To analyse the relation between antioxidant vitamins A, E, and malondialdehyde (MDA) lipoperoxidation product plasma concentrations with incident dementia. DESIGN:: A nested case-control within the PAQUID (Personnes Agées QUID) cohort. SETTING:The PAQUID population-based prospective cohort in southwestern F...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1601724

    authors： Helmer C,Peuchant E,Letenneur L,Bourdel-Marchasson I,Larrieu S,Dartigues JF,Dubourg L,Thomas MJ,Barberger-Gateau P

    更新日期：2003-12-01 00:00:00

  • Feeding problems in children with congenital heart disease: the impact on energy intake and growth outcome.

    abstract：:Cross-sectional data on growth outcome, upper-arm measurements and energy intake have been analysed according to the presence or absence of early feeding problems and poor appetite in 40 children (0.9-13 years) with congenital heart disease (CHD). At the time of study, refusal to eat or poor appetite was reported as a...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：

    authors： Thommessen M,Heiberg A,Kase BF

    更新日期：1992-07-01 00:00:00

  • A diet containing rapeseed oil-based fats does not increase lipid peroxidation in humans when compared to a diet rich in saturated fatty acids.

    abstract：OBJECTIVE:To compare the effects of a rapeseed oil-based diet containing an increased proportion of easily oxidised polyunsaturated fatty acids such as alpha-linolenic acid with a diet rich in saturated fatty acids on the degree of lipid peroxidation in the human body. DESIGN:A randomised cross-over study. SUBJECTS A...

    journal_title：European journal of clinical nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.ejcn.1601246

    authors： Södergren E,Gustafsson IB,Basu S,Nourooz-Zadeh J,Nälsén C,Turpeinen A,Berglund L,Vessby B

    更新日期：2001-11-01 00:00:00

  • Vitamin B12 and folate status in human immunodeficiency virus infection.

    abstract：:Vitamin B12 and folate status were determined in 35 male HIV seropositive patients. Of these, 16 were asymptomatic (CDC II/III) and 19 were symptomatic (CDC IV) according to the Centre for Disease Control (CDC) Classification. Deviations from normal values for serum B12, serum folate and red cell folate were not a com...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：

    authors： Dowling S,Lambe J,Mulcahy F

    更新日期：1993-11-01 00:00:00

  • Drinking water contributes to excessive iodine intake among children in Hebei, China.

    abstract：BACKGROUND/OBJECTIVES:In Hebei province, China, over six million people are potentially exposed to excessive iodine through consumption of high iodine underground drinking water and consumption of iodized salt. The aim of this study is to evaluate the contributions of drinking water and iodized salt on children's iodin...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2013.127

    authors： Lv S,Wang Y,Xu D,Rutherford S,Chong Z,Du Y,Jia L,Zhao J

    更新日期：2013-09-01 00:00:00

  • Absorption and antioxidant effects of quercetin from onions, in man.

    abstract：OBJECTIVE:To investigate the in vivo effects of quercetin following the ingestion of fried onions. DESIGN:Five healthy volunteers, three males and two females aged between 25 and 39 y, ingested 225 g of fried onions after an overnight fast and peripheral venous blood was collected 0, 2, 4, 24 and 48 h after consumptio...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1600682

    authors： McAnlis GT,McEneny J,Pearce J,Young IS

    更新日期：1999-02-01 00:00:00

  • Variation in measures of urea kinetics over four years in a single adult.

    abstract：:Urea kinetics was measured in a single woman on five occasions over four years by the prime/intermittent oral-dose method with [15N15N]-urea. On a nitrogen intake of 231 +/- 24 mg/kg/day, urea production was 198 +/- 22 mg/kg/day, with the urinary excretion of urea being 143 +/- 25 mg/kg/day. Urea hydrolysis and salvag...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：

    authors： Hibbert JM,Jackson AA

    更新日期：1991-07-01 00:00:00

  • Comparison of body composition assessment across body mass index categories by two multifrequency bioelectrical impedance analysis devices and dual-energy X-ray absorptiometry in clinical settings.

    abstract：BACKGROUND:InBody-770 and SECA mBCA 515 are multifrequency bioelectrical impedance analysis (BIA) devices, which are commonly used in the clinic to assess fat-free mass (FFM) and body fat (BF). However, the accuracy between devices in clinical settings, across different body mass index (BMI) groups remains unclear. ME...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/s41430-020-00839-5

    authors： Lahav Y,Goldstein N,Gepner Y

    更新日期：2021-01-22 00:00:00

  • Muscle mass and functional correlates of insulin sensitivity in lean young Indian men.

    abstract：BACKGROUND/OBJECTIVES:There is a high prevalence of diabetes mellitus associated with insulin resistance in Indian adults, probably due to an inappropriately high accumulation of body fat at lower body mass indices (BMIs, kg/m(2)), as well as to a lower skeletal muscle mass. Although skeletal muscle is an important sit...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2009.32

    authors： Unni US,Ramakrishnan G,Raj T,Kishore RP,Thomas T,Vaz M,Kurpad AV

    更新日期：2009-10-01 00:00:00

  • Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmö Diet and Cancer cohort.

    abstract：OBJECTIVES:The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies. SUBJECTS AND METHODS:Twenty-six women born between 1940 and 1950 were recruited ...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1602811

    authors： Sonestedt E,Ericson U,Gullberg B,Peñalvo JL,Adlercreutz H,Wirfält E

    更新日期：2008-08-01 00:00:00

  • Evaluation of Uosm:Posm ratio as a hydration biomarker in free-living, healthy young women.

    abstract：BACKGROUND/OBJECTIVES:Urinary and plasma indices are utilized to assess whole-body water balance in healthy adults, whereas the urine-to-plasma osmolality ratio (Uosm:Posm) rarely is. To explore the efficacy of Uosm:Posm as a hydration biomarker, diet records of 120 college women were analyzed (beverage water+food wate...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2013.79

    authors： Armstrong LE,Johnson EC,Munoz CX,Le Bellego L,Klein A,McKenzie AL,Casa DJ,Maresh CM

    更新日期：2013-09-01 00:00:00

  • Nutrition transition in a middle-income country: 22-year trends in the Seychelles.

    abstract：BACKGROUND/OBJECTIVES:There is little objective information regarding nutrition transition in African countries. We assessed trends in nutrition patterns in the Seychelles between 1989 and 2011. SUBJECTS/METHODS:Population-based samples were obtained in 1989, 1994 and 2011 and participants aged 25-44 are considered in...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/ejcn.2012.199

    authors： Cardoso I,Bovet P,Viswanathan B,Luke A,Marques-Vidal P

    更新日期：2013-02-01 00:00:00

  • In vivo antioxidant effect of green tea.

    abstract：OBJECTIVE:The object of this study was to investigate the in vivo antioxidant effect of green tea and dosage effect of green tea on antioxidant effect. DESIGN:We tested 10 healthy subjects (aged 23-25 y, five women and five men) with overnight fasting. The total antioxidant capacity of plasma was measured at baseline ...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1600994

    authors： Sung H,Nah J,Chun S,Park H,Yang SE,Min WK

    更新日期：2000-07-01 00:00:00

  • Body composition by the four-compartment model: validity of the BOD POD for assessing body fat in Mexican elderly.

    abstract：OBJECTIVE:The aims of this study were to validate BOD POD in a wide sample of healthy and independent Mexican elderly men and women subjects using the 4 compartment (4C) model as the reference method, and to evaluate the assumptions of the densitometric two-compartment (2C) model. DESIGN:Cross-sectional study designed...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章

    doi：10.1038/sj.ejcn.1602597

    authors： Alemán-Mateo H,Huerta RH,Esparza-Romero J,Méndez RO,Urquidez R,Valencia ME

    更新日期：2007-07-01 00:00:00

  • Retrograded high-amylose corn starch reduces cholic acid excretion from the small bowel in ileostomy subjects.

    abstract：OBJECTIVE:To study the short-term effect of resistant starch (RS) from retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. DESIGN:Seven healthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of ...

    journal_title：European journal of clinical nutrition

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1038/sj.ejcn.1600648

    authors： Langkilde AM,Ekwall H,Björck I,Asp NG,Andersson H

    更新日期：1998-11-01 00:00:00

  • Effect of 6 month supplementation with different combinations of an association of antioxidant nutrients on biochemical parameters and markers of the antioxidant defence system in the elderly. The Geriatrie/Min.Vit.Aox Network.

    abstract：OBJECTIVES:To study the effect of supplementation with an association of small physiological amounts of antioxidant nutrients upon biochemical parameters and indicators of oxidative stress and antioxidant enzymes. DESIGN:The study included a double-blind placebo-controlled design. SETTING:Nursing homes in different a...

    journal_title：European journal of clinical nutrition

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：

    authors： Monget AL,Richard MJ,Cournot MP,Arnaud J,Galan P,Preziosi P,Herbeth B,Favier A,Hercberg S

    更新日期：1996-07-01 00:00:00

  • Dietary patterns and longitudinal change in body mass in European children: a follow-up study on the IDEFICS multicenter cohort.

    abstract：BACKGROUND/OBJECTIVES:Longitudinal studies investigating dietary patterns (DPs) and their association with childhood overweight/obesity are lacking in Europe. We identified DPs and investigated their association with overweight/obesity and changes in body mass index (BMI) in a cohort of European children. SUBJECTS/MET...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ejcn.2013.145

    authors： Pala V,Lissner L,Hebestreit A,Lanfer A,Sieri S,Siani A,Huybrechts I,Kambek L,Molnar D,Tornaritis M,Moreno L,Ahrens W,Krogh V

    更新日期：2013-10-01 00:00:00

  • Body mass index and economic productivity.

    abstract：:The paper reviews the evidence to date on the nutritional links with productivity and then goes on to provide results from a multi-country study on the effects of increasing body mass index (BMI) on productivity. The research relating nutritional status to work capacity is more consistent than the research linking nut...

    journal_title：European journal of clinical nutrition

    pub_type： 杂志文章,多中心研究,评审

    doi：

    authors： Kennedy E,Garcia M

    更新日期：1994-11-01 00:00:00