Abstract：
OBJECTIVE:To investigate the in vivo effects of quercetin following the ingestion of fried onions. DESIGN:Five healthy volunteers, three males and two females aged between 25 and 39 y, ingested 225 g of fried onions after an overnight fast and peripheral venous blood was collected 0, 2, 4, 24 and 48 h after consumption. Quercetin in the plasma, total antioxidant capacity and susceptibility of low density lipoproteins (LDL) to oxidation were measured. RESULTS:Following the onion meal, quercetin levels increased from baseline values (28.4 +/- 1.9 ng/ml) to peak after 2 h (248.4 +/- 103.9 ng/ml), decreasing to baseline again after 24 h (P > 0.05). This was accompanied by an increase in the total antioxidant activity of the plasma from baseline (1.70 +/- 0.04 mmol/l trolox equivalents) to 1.75 +/- 0.10 mmol/l trolox equivalents after 2 h and 1.76 +/- 0.08 mmol/l trolox equivalents after 4 h. There was no significant change in the susceptibility of the plasma or the isolated LDL to oxidation over the 48 h period after consumption of the fried onions. In view of these negative findings, we isolated LDL and other lipoproteins from plasma at each time point. Quercetin was not detected in either LDL or VLDL, but was present in the HDL fraction, although this fraction also contains other proteins including albumin. CONCLUSIONS:Quercetin can be absorbed in humans from dietary sources to high enough concentrations to increase the overall antioxidant activity of the plasma. Quercetin, however, has a strong affinity for protein and provides no direct protective effect during LDL oxidation.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
McAnlis GT,McEneny J,Pearce J,Young ISdoi
10.1038/sj.ejcn.1600682subject
Has Abstractpub_date
1999-02-01 00:00:00pages
92-6issue
2eissn
0954-3007issn
1476-5640journal_volume
53pub_type
杂志文章abstract：BACKGROUND/OBJECTIVES:Colonic fermentation of dietary fiber may improve insulin sensitivity by the metabolic effects of short chain fatty acids (SCFA) in reducing free fatty acids (FFA). The main objectives of this study were to compare peripheral uptake of acetate (AC) in participants with normal (<40 pmol/l, NI) and ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2012.98
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:This study is aimed at investigating the influence of body size, body fat and sexual maturation on blood pressure (BP) in adolescents. DESIGN:A cross-sectional study. SETTING:A suburban student population of Southern Italy. SUBJECTS:One hundred ninety students attending the first and second year of a secon...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600731
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVES:To study the relationship between lipid, fatty acid and lipid-rich food intake and current asthma in a group of Spanish schoolchildren. SUBJECTS/METHODS:The subjects of this cross-sectional study were 638 Spanish schoolchildren (8-13 years of age). The weight and height of all the subjects were recorded. A ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.127
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVES:To stimulate novel sustainable solutions to the problem of the nutritional iron deficiency, we asked: How does Nature insure proper iron nutrition of embryos and neonatal animals? Estimates of iron deficiency world-wide are 30% of the population, with women and children at the greatest risk. Recent studies l...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1997-11-01 00:00:00
abstract：OBJECTIVE:To examine the effect of low-dose fish oil supplementation on specific growth factors, purported to play a central role in lesion formation, and also on the total growth factor activity of serum, as assessed by the induction of DNA synthesis in cultured human arterial smooth muscle cells. DESIGN:Randomized p...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601076
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:To describe the availability of food items at primary and secondary schools in Belgium-Flanders and to examine the influence of school food policy (availability of food items, school food rules, nutrition education programmes) and aggregated school socioeconomical status (AGG SES) on the consumption of fruit,...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602068
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Several factors affect the mental performance of children. The importance that parents attribute to food-related determinants, compared with genetic, socio-economic and school environment, was investigated. SUBJECTS/METHODS:Parents of school children (aged 4-11) were recruited through state prima...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.214
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:To investigate the prevalence of low body weight in Beijing pubertal girls and to establish the cut-off for body mass index (BMI) for underweight for Chinese pubertal girls. DESIGN:Cross-sectional study. SETTING:Three socioeconomic areas (rural, suburban and urban) in Beijing, China. SUBJECTS:Random sample...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601599
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Children born to human immunodeficiency virus (HIV)-infected women are susceptible to undernutrition, but modifiable risk factors and the time course of the development of undernutrition have not been well characterized. The objective of this study was to identify maternal, socioeconomic and child...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2012.136
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Neuropeptide Y (NpY) is an important factor in neuropeptide signalling, and significantly change in the blood and cerebrospinal fluid (CSF) during chronic kidney disease (CKD) progression. However, the role of NpY remains unclear. We aimed to investigate the associations between NpY levels, nutrit...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2015.67
更新日期：2015-06-01 00:00:00
abstract：:The present study tested the hypotheses that: (a) individual body composition estimates obtained with the Durnin-Womersley (D-W) equations have low validity in certain populations in developing countries; (b) there exists a poor relationship between the body mass index (BMI) and body composition estimates (fat mass (B...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to assess how the glycaemic potency (blood glucose (BG)-raising potential) of breakfast is associated with cognitive function (CF) in school children, taking into account important confounders, including iron status, underlying physiological adaptations and socio-economic status. M...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2010.96
更新日期：2010-09-01 00:00:00
abstract：:Both high and low vitamin D statuses have been associated with lower memory function. Apolipoprotein E (APOE) ɛ4 alleles have been associated with reduced memory function, and separately with higher vitamin D concentrations. This report aims to examine if the presence of APOE ɛ4 alleles contributes to the relationship...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2014.201
更新日期：2015-04-01 00:00:00
abstract：:The principal metabolic function of vitamin B6 is in amino acid metabolism, although the greater part of the body's vitamin B6 is in muscle, associated with glycogen phosphorylase, and the vitamin also has an important role in the actions of steroid hormones. It is usual to calculate vitamin B6 requirements relative t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:To determine the effects of dietary consumption of Bifidobacterium lactis (strain HN019, DR10TM) on natural immunity. DESIGN:A randomized, double blind, placebo-controlled clinical trial. SETTING:Janeway Medical Centre, Memorial University, St Johns, Newfoundland. SUBJECTS:Twenty-five healthy elderly volun...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1600938
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:InBody-770 and SECA mBCA 515 are multifrequency bioelectrical impedance analysis (BIA) devices, which are commonly used in the clinic to assess fat-free mass (FFM) and body fat (BF). However, the accuracy between devices in clinical settings, across different body mass index (BMI) groups remains unclear. ME...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00839-5
更新日期：2021-01-22 00:00:00
abstract：:Ingested protein is made available to the body following digestion and absorption as amino acids and contributes to the body's demand for amino acids for protein synthesis and other metabolic pathways. As the pattern of amino acids required for metabolism is substantially different from that ingested, extensive metabo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/sj.ejcn.1600743
更新日期：1999-04-01 00:00:00
abstract：:Food intake, meal frequency and occurrence of vomiting and purging were assessed in 20 female patients with anorexia nervosa (AN) by two dietitians by means of a dietary history over the past month. Ten lean healthy women and 10 of normal weight served as two groups of controls. Two self-administered questionnaires, c...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:Administration of doses of linoleic acid (LA) up to 36 g/d in humans raised blood levels of linoleic acid but not of its metabolites. This is probably because the conversion of LA to gamma-linolenic acid (GLA) is slow and rate-limiting. We have found that administration of relatively small amounts of GLA, up to 360 mg...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:To investigate the association between dietary patterns and risk of a first nonfatal acute myocardial infarction (MI) in Costa Rican adults. DESIGN:Population-based case-control study. SUBJECTS:A total of 496 incident MI cases and 518 population-based randomly selected controls matched to the cases by age (...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602381
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The prolongation of healthy life expectancy (HALE) is a core issue of health policy in many countries. The purpose of this study is to clarify the relationship between dietary diversity and HALE using international databases. MATERIALS/METHODS:HALE data by country were derived from the Global Bur...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0270-3
更新日期：2019-03-01 00:00:00
abstract：:Nutrient intake was assessed for 15 long-stay elderly patients by 7-d weighed inventory. Analysis revealed neither significant day-to-day nor weekday/weekend variations for any studied nutrient except fibre. It would appear that acceptable indications of customary intake in this population can be achieved by measureme...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:We investigated the inhibitory effect of calcium on iron absorption in 57 human subjects. Three studies suggested that the effect is not located in the gastrointestinal tract. The presence of phytate in a meal and formation of calcium-iron-phytate complexes is not a prerequisite for the inhibition. The relative increa...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章
doi：
更新日期：1992-05-01 00:00:00
abstract：OBJECTIVE:To assess the validity of two diet quality indexes-food variety score (FVS) and diet diversity score (DDS) in Western Mali. DESIGN:In two separate studies (A and B), FVS and DDS were derived from a food frequency questionnaire (FFQ) and were compared with the same scores and with measures of nutrient adequac...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601686
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the Europe...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2013.235
更新日期：2014-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Youth with type 1 diabetes (T1DM) are at substantially increased risk for adverse vascular outcomes, but little is known about the influence of dietary behavior on cardiovascular disease (CVD) risk profile. We aimed to identify dietary intake patterns associated with CVD risk factors and evaluate ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,多中心研究
doi：10.1038/ejcn.2014.96
更新日期：2014-12-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:'Slowly digestible' carbohydrates have been claimed to reduce appetite through their effects on postprandial glucose and insulin levels, but literature is inconsistent. The inconsistencies between studies might be explained by factors other than glycemic effects per se, for example, nutritional or...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2010.189
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:Total body water can be calculated using stable isotopes by two alternative approaches known as the plateau method and the back extrapolation method. These methods treat the isotopic data in different ways and consequently do not necessarily produce identical values for total body water. Total body water was ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:We studied effects of dose and treatment duration during low-dose iron supplementation in premenopausal, non-pregnant women, with initial serum ferritin and haemoglobin concentrations < 20 micrograms x l-1 and > or = 120 g x l-1, respectively. The study was randomized, double-blind and placebo-controlled. Three groups...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-10-01 00:00:00
abstract：OBJECTIVE:To compare the most commonly used equations to predict body fatness from skinfold thickness, in male and female adolescents, with dual-energy X-ray absorptiometry (DXA) as a reference method of fatness measurement. DESIGN:Cross-sectional nutrition survey. SETTING:General adolescent population from Zaragoza ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602226
更新日期：2005-10-01 00:00:00
