Abstract:
:Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease develop an aberrant immune response to environmental triggers. Evidence suggests that microbiota residing in the gastrointestinal tract play an important role in the development and perpetuation of the disease. In this review, we discuss the role of microbes in the development of a healthy gut, their role in the development of diseases in general, and their role in the development of IBD. Advances in molecular technologies and bioinformatics will continue to further our insight into the structure of the microbial community, the function of the microbial community as a whole, and the interaction of this community with the host immune system. The latter two are crucial to understanding the role of microbes in IBD. The field has advanced significantly in recent years, and the future is very promising as we begin to elucidate the microbial basis of IBD.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Raffals LE,Chang EBdoi
10.5009/gnl15491subject
Has Abstractpub_date
2016-07-15 00:00:00pages
502-8issue
4eissn
1976-2283issn
2005-1212pii
gnl15491journal_volume
10pub_type
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