Abstract:
:Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. This cancer commonly arises against a background of chronic liver disease. As a result, a patient with HCC requires multidisciplinary care. Treatment options vary widely based on tumor burden and metastases. The most widely utilized staging system is the Barcelona Clinic Liver Cancer staging system, which recommends treatments based on tumor size and the underlying liver disease and functional status of the patient. Treatment options range from surgical resection or transplantation to locoregional therapies with modalities such as radiofrequency ablation and transarterial chemoembolization to systemic chemotherapies. Future care involves the development of combination therapies that afford the best tumor response, further clarification of the patients best suited for therapies and the development of new oral chemotherapeutic agents.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Au JS,Frenette CTdoi
10.5009/gnl15022subject
Has Abstractpub_date
2015-07-01 00:00:00pages
437-48issue
4eissn
1976-2283issn
2005-1212pii
gnl15022journal_volume
9pub_type
杂志文章,评审相关文献
Gut and Liver文献大全abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management...
journal_title:Gut and liver
pub_type: 杂志文章,实务指引
doi:10.5009/gnl19024
更新日期:2019-05-15 00:00:00
abstract:BACKGROUND/AIMS:We aimed to assess the effectiveness of self-expanding metal stent (SEMS) insertion by evaluating the learning curve in relation to the experience of an endoscopist. METHODS:We retrospectively analyzed the outcomes of 120 SEMS insertion procedures performed by one endoscopist in patients with malignant...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.3.328
更新日期:2012-07-01 00:00:00
abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17091
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.3.363
更新日期:2013-05-01 00:00:00
abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16078
更新日期:2017-07-15 00:00:00
abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15426
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND/AIMS:Several precut techniques have been used to gain biliary access for difficult cases. The aim of this study was to evaluate the success and complication rates of two precut techniques, transpancreatic septotomy (TPS) and needle knife infundibulotomy (NKI), in difficult biliary cannulation due to the pres...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14223
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND/AIMS:Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions. Since halitosis is closely associated with volatile sulfur compounds (VSCs), we used a Halimeter ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2008.2.2.113
更新日期:2008-09-01 00:00:00
abstract:Background/Aims:This study aimed to elucidate the epidemiological and clinical characteristics of chronic hepatitis C (CHC) patients in South Korea from 2007 to 2017 and to compare the treatment patterns between two periods before and after the first approval of direct-acting antivirals (DAA) in South Korea in 2015. M...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl19005
更新日期:2020-03-15 00:00:00
abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.S1.S82
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND/AIMS:Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.5.532
更新日期:2013-09-01 00:00:00
abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl19301
更新日期:2021-01-15 00:00:00
abstract::We report a case of malignant fibrous histiocytoma (MFH) of the right buttock with multiple metastases to the lung, bone, and small intestine. He received resection and end-to-end anastomosis of the jejunum for the jejunal metastatic tumor, and mass excision of the metastatic tumor of the left femur followed by closed...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2008.2.3.213
更新日期:2008-12-01 00:00:00
abstract::During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding e...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19265
更新日期:2021-01-15 00:00:00
abstract::The use of self-expanding metallic stents in the upper gastrointestinal tract, placed under radiologic imaging or endoscopic guidance, is the current treatment of choice for the palliation of malignant gastrointestinal outlet obstructions. Advances in metallic stent design and delivery systems have progressed to the s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.S1.S19
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect of the synthetic S-allyl-L-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle con...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15584
更新日期:2016-09-15 00:00:00
abstract::Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of clinical investigations and molecular pathological analyses of the roles of H. pylori eradication and ...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19079
更新日期:2020-05-15 00:00:00
abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...
journal_title:Gut and liver
pub_type: 杂志文章,实务指引
doi:10.5009/gnl14460
更新日期:2015-05-23 00:00:00
abstract:BACKGROUND/AIMS:The quality of bowel preparation (QBP) is the important factor in performing a successful colonoscopy. Several factors influencing QBP have been reported; however, some factors, such as the optimal preparation-to-colonoscopy time interval, remain controversial. This study aimed to determine the factors ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13228
更新日期:2014-11-01 00:00:00
abstract::This systematic review aimed to assess the efficacy of the current approach to tissue traction during the endoscopic submucosal dissection (ESD) of superficial esophageal cancer, early gastric cancer, and colorectal neoplasms. We performed a systematic electronic literature search of articles published in PubMed and s...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19266
更新日期:2020-11-15 00:00:00
abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16033
更新日期:2016-09-15 00:00:00
abstract::The goal of antiviral therapy for patients with chronic hepatitis C virus (HCV) infection is to attain a sustained virologic response (SVR), which is defined as undetectable serum HCV-RNA levels at 6 months after the cessation of treatment. Major improvements in antiviral therapy for chronic hepatitis C have occurred ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.117
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.4.475
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND/AIMS:The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A. ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.4.500
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.2.95
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14018
更新日期:2015-01-01 00:00:00
abstract:Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18261
更新日期:2019-01-15 00:00:00
abstract:Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular inv...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl16281
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.1.113
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.1.41
更新日期:2009-03-01 00:00:00