Management of Hepatocellular Carcinoma: Current Status and Future Directions.

Abstract:

:Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. This cancer commonly arises against a background of chronic liver disease. As a result, a patient with HCC requires multidisciplinary care. Treatment options vary widely based on tumor burden and metastases. The most widely utilized staging system is the Barcelona Clinic Liver Cancer staging system, which recommends treatments based on tumor size and the underlying liver disease and functional status of the patient. Treatment options range from surgical resection or transplantation to locoregional therapies with modalities such as radiofrequency ablation and transarterial chemoembolization to systemic chemotherapies. Future care involves the development of combination therapies that afford the best tumor response, further clarification of the patients best suited for therapies and the development of new oral chemotherapeutic agents.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Au JS,Frenette CT

doi

10.5009/gnl15022

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

437-48

issue

4

eissn

1976-2283

issn

2005-1212

pii

gnl15022

journal_volume

9

pub_type

杂志文章,评审
  • 2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl19024

    authors: Korean Liver Cancer Association.,National Cancer Center.

    更新日期:2019-05-15 00:00:00

  • The learning curve for colorectal stent insertion for the treatment of malignant colorectal obstruction.

    abstract:BACKGROUND/AIMS:We aimed to assess the effectiveness of self-expanding metal stent (SEMS) insertion by evaluating the learning curve in relation to the experience of an endoscopist. METHODS:We retrospectively analyzed the outcomes of 120 SEMS insertion procedures performed by one endoscopist in patients with malignant...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.3.328

    authors: Lee JH,Yoon JY,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2012-07-01 00:00:00

  • Knowledge Gaps among Physicians Caring for Multiethnic Populations at Increased Gastric Cancer Risk.

    abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17091

    authors: Shah SC,Itzkowitz SH,Jandorf L

    更新日期:2018-01-15 00:00:00

  • Use of antithrombin and thrombomodulin in the management of disseminated intravascular coagulation in patients with acute cholangitis.

    abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.3.363

    authors: Nakahara K,Okuse C,Adachi S,Suetani K,Kitagawa S,Okano M,Michikawa Y,Takagi R,Shigefuku R,Itoh F

    更新日期:2013-05-01 00:00:00

  • Ultrasonography for Noninvasive Assessment of Portal Hypertension.

    abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16078

    authors: Maruyama H,Yokosuka O

    更新日期:2017-07-15 00:00:00

  • Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B.

    abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15426

    authors: Shim JJ,Oh IH,Kim SB,Kim JW,Lee CK,Jang JY,Lee JS,Kim BH

    更新日期:2016-11-15 00:00:00

  • Different Strategies for Transpancreatic Septotomy and Needle Knife Infundibulotomy Due to the Presence of Unintended Pancreatic Cannulation in Difficult Biliary Cannulation.

    abstract:BACKGROUND/AIMS:Several precut techniques have been used to gain biliary access for difficult cases. The aim of this study was to evaluate the success and complication rates of two precut techniques, transpancreatic septotomy (TPS) and needle knife infundibulotomy (NKI), in difficult biliary cannulation due to the pres...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14223

    authors: Lee YJ,Park YK,Lee MJ,Lee KT,Lee KH,Lee JK

    更新日期:2015-07-01 00:00:00

  • Volatile sulfur compounds as a predictor for esophagogastroduodenal mucosal injury.

    abstract:BACKGROUND/AIMS:Halitosis is a symptom that bothers patients more socially than medically and its pathogenic mechanisms are unclear and treatment armamenterium is limited. Clinicians generally ignored active interventions. Since halitosis is closely associated with volatile sulfur compounds (VSCs), we used a Halimeter ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2008.2.2.113

    authors: Yoo SH,Jung HS,Sohn WS,Kim BH,Ku BH,Kim YS,Park SW,Hahm KB

    更新日期:2008-09-01 00:00:00

  • Epidemiological and Clinical Characteristics of Hepatitis C Virus Infection in South Korea from 2007 to 2017: A Prospective Multicenter Cohort Study.

    abstract:Background/Aims:This study aimed to elucidate the epidemiological and clinical characteristics of chronic hepatitis C (CHC) patients in South Korea from 2007 to 2017 and to compare the treatment patterns between two periods before and after the first approval of direct-acting antivirals (DAA) in South Korea in 2015. M...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl19005

    authors: Nam JY,Jang ES,Kim YS,Lee YJ,Kim IH,Cho SB,Lee HC,Bae SH,Ki M,Choi HY,Lee EY,Jeong SH

    更新日期:2020-03-15 00:00:00

  • Multimodal oncological therapy comprising stents, brachytherapy, and regional chemotherapy for cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S82

    authors: Andrašina T,Válek V,Pánek J,Kala Z,Kiss I,Tuček S,Slampa P

    更新日期:2010-09-01 00:00:00

  • Visceral obesity as a risk factor for left-sided diverticulitis in Japan: a multicenter retrospective study.

    abstract:BACKGROUND/AIMS:Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.5.532

    authors: Yamada E,Ohkubo H,Higurashi T,Sakai E,Endo H,Takahashi H,Uchida E,Tanida E,Izumi N,Kanesaki A,Hata Y,Matsuura T,Fujisawa N,Komatsu K,Maeda S,Nakajima A

    更新日期:2013-09-01 00:00:00

  • Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy.

    abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl19301

    authors: Chang JW,Lee HW,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Kim SU

    更新日期:2021-01-15 00:00:00

  • Peritoneal dissemination from malignant fibrous histiocytoma of the buttock: unusual metastases from a rare tumor.

    abstract::We report a case of malignant fibrous histiocytoma (MFH) of the right buttock with multiple metastases to the lung, bone, and small intestine. He received resection and end-to-end anastomosis of the jejunum for the jejunal metastatic tumor, and mass excision of the metastatic tumor of the left femur followed by closed...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2008.2.3.213

    authors: Yoo JW,Lee DH,Song HJ,Ahn JH,Kim SW,Suh C,Lee JS

    更新日期:2008-12-01 00:00:00

  • Expanding Indications for Liver Transplant: Tumor and Patient Factors.

    abstract::During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding e...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19265

    authors: Chu KK,Wong KH,Chok KS

    更新日期:2021-01-15 00:00:00

  • Gastrointestinal stent update.

    abstract::The use of self-expanding metallic stents in the upper gastrointestinal tract, placed under radiologic imaging or endoscopic guidance, is the current treatment of choice for the palliation of malignant gastrointestinal outlet obstructions. Advances in metallic stent design and delivery systems have progressed to the s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S19

    authors: Kang SG

    更新日期:2010-09-01 00:00:00

  • PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach.

    abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect of the synthetic S-allyl-L-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle con...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15584

    authors: Choi YJ,Kim N,Lee JY,Nam RH,Suh JH,Lee SM,Ham MH,Jo HJ,Shim YK,Park YH,Lee JC,Choi YJ,Lee HS,Lee DH

    更新日期:2016-09-15 00:00:00

  • Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin.

    abstract::Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of clinical investigations and molecular pathological analyses of the roles of H. pylori eradication and ...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19079

    authors: Watari J,Tomita T,Tozawa K,Oshima T,Fukui H,Miwa H

    更新日期:2020-05-15 00:00:00

  • 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma.

    abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl14460

    authors: Korean Liver Cancer Study Group (KLCSG).,National Cancer Center, Korea (NCC).

    更新日期:2015-05-23 00:00:00

  • Importance of the time interval between bowel preparation and colonoscopy in determining the quality of bowel preparation for full-dose polyethylene glycol preparation.

    abstract:BACKGROUND/AIMS:The quality of bowel preparation (QBP) is the important factor in performing a successful colonoscopy. Several factors influencing QBP have been reported; however, some factors, such as the optimal preparation-to-colonoscopy time interval, remain controversial. This study aimed to determine the factors ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13228

    authors: Kim TK,Kim HW,Kim SJ,Ha JK,Jang HH,Hong YM,Park SB,Choi CW,Kang DH

    更新日期:2014-11-01 00:00:00

  • Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection.

    abstract::This systematic review aimed to assess the efficacy of the current approach to tissue traction during the endoscopic submucosal dissection (ESD) of superficial esophageal cancer, early gastric cancer, and colorectal neoplasms. We performed a systematic electronic literature search of articles published in PubMed and s...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19266

    authors: Abe S,Wu SYS,Ego M,Takamaru H,Sekiguchi M,Yamada M,Nonaka S,Sakamoto T,Suzuki H,Yoshinaga S,Matsuda T,Oda I,Saito Y

    更新日期:2020-11-15 00:00:00

  • Biology of Cholangiocytes: From Bench to Bedside.

    abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16033

    authors: Yoo KS,Lim WT,Choi HS

    更新日期:2016-09-15 00:00:00

  • Chronic hepatitis C.

    abstract::The goal of antiviral therapy for patients with chronic hepatitis C virus (HCV) infection is to attain a sustained virologic response (SVR), which is defined as undetectable serum HCV-RNA levels at 6 months after the cessation of treatment. Major improvements in antiviral therapy for chronic hepatitis C have occurred ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.2.117

    authors: Jang JY,Chung RT

    更新日期:2011-06-01 00:00:00

  • Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.

    abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.475

    authors: Lee JY,Kim JS,Moon JM,Lim SA,Chung W,Lim EH,Lee BJ,Park JJ,Bak YT

    更新日期:2013-07-01 00:00:00

  • Comparison of the Clinical Features of Hepatitis A between HBsAg-Positive and HBsAg-Negative Patients.

    abstract:BACKGROUND/AIMS:The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A. ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.4.500

    authors: Kim KM,Eo SJ,Gwak GY,Choi MS,Lee JH,Koh KC,Yoo BC,Paik SW

    更新日期:2011-12-01 00:00:00

  • Prevalence of subjects at a high or very high risk of gastric cancer in Japan.

    abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.2.95

    authors: Yamaoka M,Nakajima S

    更新日期:2009-06-01 00:00:00

  • Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

    abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14018

    authors: Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2015-01-01 00:00:00

  • Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease.

    abstract:Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18261

    authors: Yanai S,Yamaguchi S,Nakamura S,Kawasaki K,Toya Y,Yamada N,Eizuka M,Uesugi N,Umeno J,Esaki M,Okimoto E,Ishihara S,Sugai T,Matsumoto T

    更新日期:2019-01-15 00:00:00

  • Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan.

    abstract:Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular inv...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl16281

    authors: Lee SY,Yoshida N,Dohi O,Lee SP,Ichikawa D,Kim JH,Sung IK,Park HS,Otsuji E,Itoh Y,Shim CS,Han HS,Kishimoto M,Naito Y

    更新日期:2017-05-15 00:00:00

  • One-Step Transpapillary Balloon Dilation under Cap-Fitted Endoscopy without a Preceding Sphincterotomy for the Removal of Bile Duct Stones in Billroth II Gastrectomy.

    abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.1.113

    authors: Lee TH,Hwang JC,Choi HJ,Moon JH,Cho YD,Yoo BM,Park SH,Kim JH,Kim SJ

    更新日期:2012-01-01 00:00:00

  • Cytapheresis in patients with severe ulcerative colitis after failure of intravenous corticosteroid: a long-term retrospective cohort study.

    abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.1.41

    authors: Fukunaga K,Nagase K,Kusaka T,Hida N,Ohda Y,Yoshida K,Tozawa K,Kamikozuru K,Iimuro M,Nakamura S,Miwa H,Matsumoto T

    更新日期:2009-03-01 00:00:00