Chronic hepatitis C.

Abstract:

:The goal of antiviral therapy for patients with chronic hepatitis C virus (HCV) infection is to attain a sustained virologic response (SVR), which is defined as undetectable serum HCV-RNA levels at 6 months after the cessation of treatment. Major improvements in antiviral therapy for chronic hepatitis C have occurred in the past decade. The addition of ribavirin to interferon-alfa therapy and the introduction of pegylated interferon (PEG-IFN) have substantially improved SVR rates in patients with chronic hepatitis C. The optimization of HCV therapy with PEG-IFN and ribavirin continues to evolve. Studies are ongoing that use viral kinetics to tailor therapy to an individual's antiviral response and determine the ideal length of treatment to maximize the chance of SVR. Improved SVR can be achieved with new specific inhibitors that target the HCV NS3/4A protease and the NS5B polymerase. Several long-term follow-up studies have shown that SVR, when achieved, is associated with a very low risk of virologic relapse. Furthermore, antiviral therapy can reduce the morbidity and mortality rates associated with chronic hepatitis C by reducing fibrosis progression, the incidence of cirrhosis, and hepatocellular carcinoma.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Jang JY,Chung RT

doi

10.5009/gnl.2011.5.2.117

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

117-32

issue

2

eissn

1976-2283

issn

2005-1212

journal_volume

5

pub_type

杂志文章
  • Diagnostic dilemma in an unusual case of common bile duct obstruction.

    abstract::Biliary obstructions are rarely caused by a foreign body and have received sparse attention. We present an unusual case with pruritis and abdominal pain caused by impacted full length surgical gauze within the common bile duct. The patient had previously undergone an open cholecystectomy. Radiological investigations w...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.2.245

    authors: Bhandari V,Singh M,Vyas HG,Sharma N,Chejara R

    更新日期:2011-06-01 00:00:00

  • Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease.

    abstract:Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18261

    authors: Yanai S,Yamaguchi S,Nakamura S,Kawasaki K,Toya Y,Yamada N,Eizuka M,Uesugi N,Umeno J,Esaki M,Okimoto E,Ishihara S,Sugai T,Matsumoto T

    更新日期:2019-01-15 00:00:00

  • Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy.

    abstract:Background/Aims:Although forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignanc...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18006

    authors: Kim MS,Kim SG,Chung H,Kim J,Hong H,Lee HJ,Kim HJ,Kim MA,Kim WH,Jung HC

    更新日期:2018-09-15 00:00:00

  • Primary squamous cell carcinoma of the liver initially presenting with pseudoachalasia.

    abstract::Pseudoachalasia secondary to primary squamous cell carcinoma (SCC) of the liver is extremely rare and has not been reported until now. Here, we report a unique case of primary SCC of the liver initially presenting with progressive dysphagia along with short periods of significant weight loss. A 58-year-old man initial...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.2.275

    authors: Choi MK,Kim GH,Song GA,Nam HS,Yi YS,Ahn KH,Kim S,Kim JY,Park DY

    更新日期:2012-04-01 00:00:00

  • The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.

    abstract:BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl13457

    authors: Kim YC,Kim JH,Cheung DY,Kim TH,Jun EJ,Oh JW,Kim CW,Chung WC,Kim BW,Kim SS,Kim JI,Park SH,Kim JK

    更新日期:2015-09-23 00:00:00

  • Barrett's esophagus and cancer risk: how research advances can impact clinical practice.

    abstract::Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore poses a clinical conundrum. Cur...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl.2014.8.4.356

    authors: di Pietro M,Alzoubaidi D,Fitzgerald RC

    更新日期:2014-07-01 00:00:00

  • Relationship between the Extent of DNA Damage and Gastritis in Normal and Helicobacter pylori-Infected Patients.

    abstract:BACKGROUND/AIMS:The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -neg...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.3.315

    authors: Marie MA,Altahir IE

    更新日期:2011-09-01 00:00:00

  • Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

    abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.3.338

    authors: Hwangbo Y,Kim HJ,Park JS,Ryu KN,Kim NH,Shim J,Jang JY,Dong SH,Kim BH,Chang YW,Chang R

    更新日期:2010-09-01 00:00:00

  • Risk factors of post endoscopic retrograde cholangiopancreatography bacteremia.

    abstract:BACKGROUND/AIMS:Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study was to investigate the risk factors of post-ERCP bacteremia. METHODS:Among patients who underwen...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.2.228

    authors: Kwak MS,Jang ES,Ryu JK,Kim YT,Yoon YB,Park JK

    更新日期:2013-03-01 00:00:00

  • Knowledge Gaps among Physicians Caring for Multiethnic Populations at Increased Gastric Cancer Risk.

    abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17091

    authors: Shah SC,Itzkowitz SH,Jandorf L

    更新日期:2018-01-15 00:00:00

  • Current Definition of and Controversial Issues Regarding Postoperative Pancreatic Fistulas.

    abstract::The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl18229

    authors: Marchegiani G,Andrianello S,Salvia R,Bassi C

    更新日期:2019-03-15 00:00:00

  • Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection.

    abstract::This systematic review aimed to assess the efficacy of the current approach to tissue traction during the endoscopic submucosal dissection (ESD) of superficial esophageal cancer, early gastric cancer, and colorectal neoplasms. We performed a systematic electronic literature search of articles published in PubMed and s...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19266

    authors: Abe S,Wu SYS,Ego M,Takamaru H,Sekiguchi M,Yamada M,Nonaka S,Sakamoto T,Suzuki H,Yoshinaga S,Matsuda T,Oda I,Saito Y

    更新日期:2020-11-15 00:00:00

  • An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia.

    abstract:BACKGROUND/AIMS:This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. METHODS:We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submucosal dissection. All tissue sample...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.6.688

    authors: Chung WC,Jung SH,Joo KR,Kim MJ,Youn GJ,Kim Y,Lee JS,Lee H,Jung JH,Lee YK

    更新日期:2013-11-01 00:00:00

  • Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer.

    abstract:BACKGROUND/AIMS:The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS:The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15133

    authors: Bae YS,Kim H,Noh SH,Kim H

    更新日期:2015-09-23 00:00:00

  • Multimodal oncological therapy comprising stents, brachytherapy, and regional chemotherapy for cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S82

    authors: Andrašina T,Válek V,Pánek J,Kala Z,Kiss I,Tuček S,Slampa P

    更新日期:2010-09-01 00:00:00

  • Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.

    abstract:Background/Aims:Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18296

    authors: Takajo T,Tomita K,Tsuchihashi H,Enomoto S,Tanichi M,Toda H,Okada Y,Furuhashi H,Sugihara N,Wada A,Horiuchi K,Inaba K,Hanawa Y,Shibuya N,Shirakabe K,Higashiyama M,Kurihara C,Watanabe C,Komoto S,Nagao S,Kimura K,Mi

    更新日期:2019-05-15 00:00:00

  • Antireflux Surgery in Korea: A Nationwide Study from 2011 to 2014.

    abstract:BACKGROUND/AIMS:Although laparoscopic fundoplication is a well-established therapy for gastroesophageal reflux disease (GERD) in Western countries, the mainstay of GERD treatment in Korea is long-term proton pump inhibitor (PPI) use. The aim of the present study was to evaluate nationwide data regarding antireflux surg...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15406

    authors: Lee JH,Park JM,Han SU,Kim JJ,Song KY,Ryu SW,Seo KW,Kim HI,Kim W,Korean Antireflux Surgery Study (KARS) Group.

    更新日期:2016-09-15 00:00:00

  • Comparison of the Clinical Features of Hepatitis A between HBsAg-Positive and HBsAg-Negative Patients.

    abstract:BACKGROUND/AIMS:The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A. ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.4.500

    authors: Kim KM,Eo SJ,Gwak GY,Choi MS,Lee JH,Koh KC,Yoo BC,Paik SW

    更新日期:2011-12-01 00:00:00

  • Epidemiological and Clinical Characteristics of Hepatitis C Virus Infection in South Korea from 2007 to 2017: A Prospective Multicenter Cohort Study.

    abstract:Background/Aims:This study aimed to elucidate the epidemiological and clinical characteristics of chronic hepatitis C (CHC) patients in South Korea from 2007 to 2017 and to compare the treatment patterns between two periods before and after the first approval of direct-acting antivirals (DAA) in South Korea in 2015. M...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl19005

    authors: Nam JY,Jang ES,Kim YS,Lee YJ,Kim IH,Cho SB,Lee HC,Bae SH,Ki M,Choi HY,Lee EY,Jeong SH

    更新日期:2020-03-15 00:00:00

  • Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center.

    abstract:Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18489

    authors: Xu L,Li L,Wang P,Zhang M,Zhang Y,Hao X,Yan L,Li B,Wen T,Xu M

    更新日期:2019-11-15 00:00:00

  • Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

    abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14018

    authors: Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2015-01-01 00:00:00

  • Expanding Indications for Liver Transplant: Tumor and Patient Factors.

    abstract::During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding e...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19265

    authors: Chu KK,Wong KH,Chok KS

    更新日期:2021-01-15 00:00:00

  • 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma.

    abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl14460

    authors: Korean Liver Cancer Study Group (KLCSG).,National Cancer Center, Korea (NCC).

    更新日期:2015-05-23 00:00:00

  • Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.

    abstract:BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14120

    authors: Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2015-09-23 00:00:00

  • Proteomic identification of proteins suggestive of immune-mediated response or neuronal degeneration in serum of achalasia patients.

    abstract:BACKGROUND/AIMS:The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune-mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune-mediated response or neuronal degeneratio...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.411

    authors: Im SK,Yeo M,Lee KJ

    更新日期:2013-07-01 00:00:00

  • Clinical efficacy of endoscopic treatment for benign colorectal stricture: balloon dilatation versus stenting.

    abstract:BACKGROUND/AIMS:There has been a lack of research comparing balloon dilatation and self-expandable metal stent (SEMS) placement to determine which is better for long-term clinical outcomes in patients with benign colorectal strictures. We aimed to compare the clinical efficacy and complication rates of balloon dilatati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13326

    authors: Park CH,Yoon JY,Park SJ,Cheon JH,Kim TI,Lee SK,Lee YC,Kim WH,Hong SP

    更新日期:2015-01-01 00:00:00

  • Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.

    abstract::Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease deve...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl15491

    authors: Raffals LE,Chang EB

    更新日期:2016-07-15 00:00:00

  • Learning curves for colonoscopy: a prospective evaluation of gastroenterology fellows at a single center.

    abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.1.31

    authors: Chung JI,Kim N,Um MS,Kang KP,Lee D,Na JC,Lee ES,Chung YM,Won JY,Lee KH,Nam TM,Lee JH,Choi HC,Lee SH,Park YS,Hwang JH,Kim JW,Jeong SH,Lee DH

    更新日期:2010-03-01 00:00:00

  • Electrohydraulic Lithotripsy for Difficult Bile Duct Stones under Endoscopic Retrograde Cholangiopancreatography and Peroral Transluminal Cholangioscopy Guidance.

    abstract:Background/Aims:Electrohydraulic lithotripsy (EHL) under endoscopic retrograde cholangiopancreatography (ERCP) guidance can be an option to treat difficult stones. Recently, a digital, single-operator cholangioscope (SPY-DS) has become available. Peroral transluminal cholangioscopy (PTLC) using SPY-DS has also been rep...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17352

    authors: Kamiyama R,Ogura T,Okuda A,Miyano A,Nishioka N,Imanishi M,Takagi W,Higuchi K

    更新日期:2018-07-15 00:00:00

  • Endoscopic and Clinical Factors Affecting the Prognosis of Colorectal Endoscopic Submucosal Dissection-Related Perforation.

    abstract:BACKGROUND/AIMS:Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. METH...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15252

    authors: Kang DU,Choi Y,Lee HS,Lee HJ,Park SH,Yang DH,Yoon SM,Kim KJ,Ye BD,Myung SJ,Yang SK,Kim JH,Byeon JS

    更新日期:2016-05-23 00:00:00