Abstract:
BACKGROUND/AIMS:Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. METHODS:Forty-three patients with colorectal ESD-related perforation were evaluated. The perforations were classified as endoscopic or radiologic perforations. The patients' medical records and endoscopic pictures were analyzed. RESULTS:The clinical outcomes were assessed by the duration of nil per os, intravenous antibiotics administration, and hospital stays, which were 2.7±1.5, 4.9±2.3, and 5.1±2.3 days, respectively. Multivariate analyses revealed that a larger tumor size, ESD failure, specific endoscopists, and abdominal pain were independently related to a poorer outcome. The time between perforation and clipping was 15.8±25.4 minutes in the endoscopic perforation group. The multivariate analysis of this group indicated that delayed clipping, specific endoscopists, and abdominal pain were independently associated with poorer outcomes. CONCLUSIONS:Tumor size, ESD failure, abdominal pain, and the endoscopist were factors that affected the clinical outcomes of patients with colorectal ESD-related perforation. The time between the perforation and clipping was an additional factor influencing the clinical course of endoscopic perforation. Decreasing this time period may improve outcomes.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Kang DU,Choi Y,Lee HS,Lee HJ,Park SH,Yang DH,Yoon SM,Kim KJ,Ye BD,Myung SJ,Yang SK,Kim JH,Byeon JSdoi
10.5009/gnl15252subject
Has Abstractpub_date
2016-05-23 00:00:00pages
420-8issue
3eissn
1976-2283issn
2005-1212pii
gnl15252journal_volume
10pub_type
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