A case of recurrent pancreatitis induced by trimethoprim-sulfamethoxazole re-exposure.

Abstract:

:A 32-year-old man presented with epigastric pain. He had a previous episode of acute pancreatitis of undetermined cause 2 years earlier. The patient had taken trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily because of acute urethritis 3 days prior to admission. No definite cause of acute pancreatitis could be identified on baseline studies. A thorough history-taking revealed that the patient had an episode of acute pancreatitis while taking trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily for 2 weeks for prostatitis prior to the previous admission. Therefore, a cause-and-effect relationship between trimethoprim-sulfamethoxazole (TMP-SMX) and repeated episodes of pancreatitis was highly suggested. The patient was presumably diagnosed as TMP-SMX-induced pancreatitis. The final diagnosis was TMP-SMX-induced pancreatitis. Since drugs are rare causes of acute pancreatitis and the diagnosis of drug-induced pancreatitis is difficult to establish, we report this interesting case along with a review of medical literature.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Park TY,Oh HC,Do JH

doi

10.5009/gnl.2010.4.2.250

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

250-2

issue

2

eissn

1976-2283

issn

2005-1212

journal_volume

4

pub_type

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