Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts.

Abstract:

Background/Aims:Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiological significance. Methods:Bile duct tissues of Sprague-Dawley rats were isolated by enzymatic digestion and mechanical isolation, and then divided into large and small bile duct tissues. Immunohistochemistry, real-time polymerase chain reaction and Western blotting were used to determine the expression of the apical sodium-dependent bile acid transporter (ASBT), ileal bile acid binding protein (IBABP), and basolateral organic solute transporter α (Ostα) in the biliary tract system of rats. Differences in the expression and distribution of these proteins were analyzed. Results:In cholangiocytes, ASBT and IBABP were mainly expressed in cholangiocytes of the large bile ducts, in which the expression of both was significantly higher than that in the small ducts (p<0.05). Ostα was simultaneously expressed in cholangiocytes of both the large and small bile ducts, showing no significant difference in expression between the two groups of bile ducts (p>0.05). Conclusions:Bile acid transporters are expressed and heterogeneously distributed in rat bile ducts, indicating that bile acid reabsorption by cholangiocytes might mainly occur in the large bile ducts. These findings may help explore the physiology of bile ducts and the pathogenesis of various cholangiopathies.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Luo ZL,Cheng L,Wang T,Tang LJ,Tian FZ,Xiang K,Cui L

doi

10.5009/gnl18265

subject

Has Abstract

pub_date

2019-09-15 00:00:00

pages

569-575

issue

5

eissn

1976-2283

issn

2005-1212

pii

gnl18265

journal_volume

13

pub_type

杂志文章
  • Prevalence of subjects at a high or very high risk of gastric cancer in Japan.

    abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.2.95

    authors: Yamaoka M,Nakajima S

    更新日期:2009-06-01 00:00:00

  • Expanding Indications for Liver Transplant: Tumor and Patient Factors.

    abstract::During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding e...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19265

    authors: Chu KK,Wong KH,Chok KS

    更新日期:2021-01-15 00:00:00

  • An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia.

    abstract:BACKGROUND/AIMS:This study was performed to determine the association between RUNX3 expression and Helicobacter pylori infection in premalignant gastric lesions. METHODS:We examined 107 patients with gastric epithelial dysplasia who had undergone endoscopic mucosal resection or submucosal dissection. All tissue sample...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.6.688

    authors: Chung WC,Jung SH,Joo KR,Kim MJ,Youn GJ,Kim Y,Lee JS,Lee H,Jung JH,Lee YK

    更新日期:2013-11-01 00:00:00

  • The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.

    abstract:BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl13457

    authors: Kim YC,Kim JH,Cheung DY,Kim TH,Jun EJ,Oh JW,Kim CW,Chung WC,Kim BW,Kim SS,Kim JI,Park SH,Kim JK

    更新日期:2015-09-23 00:00:00

  • Use of antithrombin and thrombomodulin in the management of disseminated intravascular coagulation in patients with acute cholangitis.

    abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.3.363

    authors: Nakahara K,Okuse C,Adachi S,Suetani K,Kitagawa S,Okano M,Michikawa Y,Takagi R,Shigefuku R,Itoh F

    更新日期:2013-05-01 00:00:00

  • Increased prevalence of colorectal neoplasia in korean patients with sporadic duodenal adenomas: a case-control study.

    abstract:BACKGROUND/AIMS:Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects. M...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.4.432

    authors: Chung WC,Lee BI,Roh SY,Kwak JW,Hwang SM,Ko YH,Oh JH,Cho H,Chae HS,Cho YS

    更新日期:2011-12-01 00:00:00

  • A case of esophageal intramural pseudodiverticulosis.

    abstract::Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flask-shaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic findings include dilatation of excretory ducts of submucosal glands. The predominant symptom is dysphagia...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.1.93

    authors: Chon YE,Hwang S,Jung KS,Lee HJ,Lee SG,Shin SK,Lee YC

    更新日期:2011-03-01 00:00:00

  • Learning curves for colonoscopy: a prospective evaluation of gastroenterology fellows at a single center.

    abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.1.31

    authors: Chung JI,Kim N,Um MS,Kang KP,Lee D,Na JC,Lee ES,Chung YM,Won JY,Lee KH,Nam TM,Lee JH,Choi HC,Lee SH,Park YS,Hwang JH,Kim JW,Jeong SH,Lee DH

    更新日期:2010-03-01 00:00:00

  • Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease.

    abstract:Background/Aims:Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl16440

    authors: Hayashi T,Saitoh S,Fukuzawa K,Tsuji Y,Takahashi J,Kawamura Y,Akuta N,Kobayashi M,Ikeda K,Fujii T,Miyati T,Kumada H

    更新日期:2017-09-15 00:00:00

  • Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.

    abstract:Background/Aims:Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18296

    authors: Takajo T,Tomita K,Tsuchihashi H,Enomoto S,Tanichi M,Toda H,Okada Y,Furuhashi H,Sugihara N,Wada A,Horiuchi K,Inaba K,Hanawa Y,Shibuya N,Shirakabe K,Higashiyama M,Kurihara C,Watanabe C,Komoto S,Nagao S,Kimura K,Mi

    更新日期:2019-05-15 00:00:00

  • Liver transplantation.

    abstract::Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.3.145

    authors: Moon DB,Lee SG

    更新日期:2009-09-01 00:00:00

  • Predictive Factors for Severe Outcomes in Ischemic Colitis.

    abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl15167

    authors: Choi SR,Jee SR,Song GA,Park SJ,Lee JH,Song CS,Park HU

    更新日期:2015-11-23 00:00:00

  • Cytapheresis in patients with severe ulcerative colitis after failure of intravenous corticosteroid: a long-term retrospective cohort study.

    abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.1.41

    authors: Fukunaga K,Nagase K,Kusaka T,Hida N,Ohda Y,Yoshida K,Tozawa K,Kamikozuru K,Iimuro M,Nakamura S,Miwa H,Matsumoto T

    更新日期:2009-03-01 00:00:00

  • Precursor lesions of pancreatic cancer.

    abstract::This review article describes morphological aspects, gene abnormalities, and mucin expression profiles in precursor lesions such as pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm (MCN) of the pancreas, as well as their relation to pancreatic d...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2008.2.3.137

    authors: Yonezawa S,Higashi M,Yamada N,Goto M

    更新日期:2008-12-01 00:00:00

  • Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.

    abstract::Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease deve...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl15491

    authors: Raffals LE,Chang EB

    更新日期:2016-07-15 00:00:00

  • Helicobacter pylori Treatment Strategies in Singapore.

    abstract::The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatm...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19308

    authors: Ang TL,Ang D

    更新日期:2021-01-15 00:00:00

  • Early Infliximab Yields Superior Long-Term Effects on Linear Growth in Pediatric Crohn's Disease Patients.

    abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17290

    authors: Choi J,Kang B,Kim MJ,Sohn I,Lee HJ,Choe YH

    更新日期:2018-05-15 00:00:00

  • Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?

    abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2007.1.2.138

    authors: Lim SH,Kim DH,Park MJ,Kim YS,Kim CH,Yim JY,Cho KR,Kim SS,Choi SH,Kim N,Cho SH,Oh BH

    更新日期:2007-12-01 00:00:00

  • Rapidly progressive hepatocellular carcinoma mimicking benign portal vein thrombosis: a case report.

    abstract::Portal vein thrombosis (PVT) is commonly associated with liver cirrhosis, irrespective of the presence of hepatocellular carcinoma (HCC). Given that malignant PVT is a poor prognostic factor in patients with HCC, it is important to differentiate malignant PVT from benign PVT. Because malignant PVT has been reported to...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.1.116

    authors: Kim JW,Lee BC,Shin SS,Heo SH,Lim HS,Jeong YY,Kang HK,Hur YH,Choi YD

    更新日期:2013-01-01 00:00:00

  • Endoscopic Ultrasound-Guided Hepaticogastrostomy: Technical Review and Tips to Prevent Adverse Events.

    abstract::Most patients who require biliary drainage can be treated by endoscopic retrograde cholangiopancreatography (ERCP)- guided procedures. However, ERCP can be challenging in patients with complications, such as malignant duodenal obstruction, or a surgically-altered anatomy, such as a Rouxen- Y anastomosis, which prevent...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl20096

    authors: Ogura T,Higuchi K

    更新日期:2020-07-23 00:00:00

  • National Endoscopy Quality Improvement Program Remains Suboptimal in Korea.

    abstract:BACKGROUND/AIMS:We evaluated the characteristics of the National Cancer Screening Program (NCSP) and opinions regarding the National Endoscopy Quality Improvement Program (NEQIP). METHODS:We surveyed physicians performing esophagogastroduodenoscopy and/or colonoscopy screenings as part of the NCSP via e-mail between J...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15623

    authors: Cha JM,Moon JS,Chung IK,Kim JO,Im JP,Cho YK,Kim HG,Lee SK,Lee HL,Jang JY,Kim ES,Jung Y,Moon CM,Kim Y,Park BY

    更新日期:2016-09-15 00:00:00

  • Gastroparesis Updates on Pathogenesis and Management.

    abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16336

    authors: Liu N,Abell T

    更新日期:2017-09-15 00:00:00

  • Biology of Cholangiocytes: From Bench to Bedside.

    abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16033

    authors: Yoo KS,Lim WT,Choi HS

    更新日期:2016-09-15 00:00:00

  • 2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl19024

    authors: Korean Liver Cancer Association.,National Cancer Center.

    更新日期:2019-05-15 00:00:00

  • Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.

    abstract:BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14120

    authors: Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2015-09-23 00:00:00

  • Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

    abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.3.338

    authors: Hwangbo Y,Kim HJ,Park JS,Ryu KN,Kim NH,Shim J,Jang JY,Dong SH,Kim BH,Chang YW,Chang R

    更新日期:2010-09-01 00:00:00

  • Long-term outcome of photodynamic therapy with systemic chemotherapy compared to photodynamic therapy alone in patients with advanced hilar cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.3.318

    authors: Hong MJ,Cheon YK,Lee EJ,Lee TY,Shim CS

    更新日期:2014-05-01 00:00:00

  • Risk factors of post endoscopic retrograde cholangiopancreatography bacteremia.

    abstract:BACKGROUND/AIMS:Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study was to investigate the risk factors of post-ERCP bacteremia. METHODS:Among patients who underwen...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.2.228

    authors: Kwak MS,Jang ES,Ryu JK,Kim YT,Yoon YB,Park JK

    更新日期:2013-03-01 00:00:00

  • Factors affecting tumor ablation during high intensity focused ultrasound treatment.

    abstract:BACKGROUND/AIMS:High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. METHODS:HIFU was ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.4.433

    authors: Hassanuddin A,Choi JH,Seo DW,Ryu CH,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2014-07-01 00:00:00

  • Management of Hepatocellular Carcinoma: Current Status and Future Directions.

    abstract::Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. This cancer commonly arises against a background of chronic liver disease. As a result, a patient with HCC requires multidisciplinary care. Treatment options vary widely based on tumor burden and metastases. The most widely utili...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl15022

    authors: Au JS,Frenette CT

    更新日期:2015-07-01 00:00:00