Abstract:
BACKGROUND/AIMS:Knowledge of the risk factors associated with adverse outcomes after percutaneous endoscopic gastrostomy (PEG) may be helpful for developing PEG recommendations. The purpose of this study was to identify the clinical risk factors associated with adverse clinical outcomes after PEG, especially regarding the use of proton pump inhibitors (PPIs). METHODS:We retrospectively reviewed the data from PEG patients at seven university hospitals between June 2006 and January 2012. All patients were followed up through February 2012 after PEG, and the clinical risk factors for adverse clinical outcomes after PEG were analyzed. RESULTS:Data from 1,021 PEG patients were analyzed. PPI users were more frequently included in the complication group than the noncomplication group (p=0.040). PEG-related complications (p=0.040) and mortality (p=0.003) were more frequent in the PPI group than in the control group. In the subgroup analysis of complicated PEG cases, infectious complications were more frequently found in the PPI group than in the control group (35.8% vs 27.8%). After adjustment for multiple possible confounding factors, PPI users (odds ratio, 1.531; 95% confidence interval, 1.017 to 2.305) and diabetic patients had increased mortality after PEG. CONCLUSIONS:PPI use may be associated with adverse outcomes in patients with PEG; however, further prospective studies investigating this issue are warranted.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Im JP,Cha JM,Kim JW,Kim SE,Ryu DY,Kim EY,Kim ER,Chang DKdoi
10.5009/gnl.2014.8.3.248subject
Has Abstractpub_date
2014-05-01 00:00:00pages
248-53issue
3eissn
1976-2283issn
2005-1212pii
gnl.2014.8.3.248journal_volume
8pub_type
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