Spontaneous regression of a large hepatocellular carcinoma with multiple lung metastases.

Abstract:

:A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer treatment or medication, including herbal preparations, the liver tumor decreased in size, and the tumor makers diminished. Moreover, after 1 year, the multiple nodules in the bilateral lungs had disappeared. Fifteen months after the first medical examination, transcatheter arterial chemoembolization (TACE) was performed for the residual HCC. Because local relapse was observed on follow-up computed tomography, a second TACE was performed 13 months after the first one. At 4 years after the second TACE (7 years after the initial medical examination), there was no recurrence of primary or metastatic lesions. Spontaneous regression of HCC is very rare, and its mechanism remains unclear. Understanding the underlying mechanism of this rare phenomenon may offer some hope of finding new therapies, even in advanced metastatic cases.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Saito T,Naito M,Matsumura Y,Kita H,Kanno T,Nakada Y,Hamano M,Chiba M,Maeda K,Michida T,Ito T

doi

10.5009/gnl13358

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

569-74

issue

5

eissn

1976-2283

issn

2005-1212

pii

gnl-08-569

journal_volume

8

pub_type

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