Gastroparesis Updates on Pathogenesis and Management.

Abstract:

:Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This article focuses on updates in the pathogenesis and management of Gp. Recent studies on full thickness biopsies of Gp patients have shed light on the complex interactions of the central, autonomic, and enteric nervous systems, which all play key roles in maintaining normal gut motility. The management of Gp has evolved beyond prokinetics and antiemetics with the use of gastric electrical stimulators (GES). In addition, this review aims to introduce the concept of gastroparesis-like syndrome (GLS). GLS helps groups of patients who have the cardinal symptoms of Gp but have a normal or rapid emptying test. Recent tests have shown that patients with Gp and GLS have similar pathophysiology, benefit greatly from GES placement, and likely should be treated in a similar manner.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Liu N,Abell T

doi

10.5009/gnl16336

subject

Has Abstract

pub_date

2017-09-15 00:00:00

pages

579-589

issue

5

eissn

1976-2283

issn

2005-1212

pii

gnl16336

journal_volume

11

pub_type

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