Abstract:
BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to evaluate the clinical utility of using plasma GPC3 and OPN as diagnostic biomarkers for HCC. METHODS:We measured the plasma levels of GPC3 and OPN in 120 HCC and 40 chronic liver disease (CLD) patients via an enzyme-linked immunosorbent assay. The diagnostic accuracy of each tumor marker was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS:The GPC3 levels in the HCC patients (75.8 ng/mL) were significantly higher (p=0.020) than the levels in patients with CLD (66.4 ng/mL). The area under the ROC curve (AUROC) values for GPC3 and OPN were 0.62 and 0.51, respectively. In subgroup analyses, including subgroups of HCC patients with low serum AFP and PIVKA II levels, the AUROC of GPC3 remained relatively high (0.66), and GPC3 showed a high sensitivity (62.1%) for detecting small HCC tumors. CONCLUSIONS:The plasma levels of GPC3 and OPN demonstrated low diagnostic accuracy for HCC. However, GPC3 may have a complementary role in diagnosing HCC in patients with nondiagnostic levels of conventional tumor markers and with small-sized tumors.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Lee HJ,Yeon JE,Suh SJ,Lee SJ,Yoon EL,Kang K,Yoo YJ,Kim JH,Seo YS,Yim HJ,Byun KSdoi
10.5009/gnl.2014.8.2.177subject
Has Abstractpub_date
2014-03-01 00:00:00pages
177-85issue
2eissn
1976-2283issn
2005-1212journal_volume
8pub_type
杂志文章相关文献
Gut and Liver文献大全abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect of the synthetic S-allyl-L-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle con...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15584
更新日期:2016-09-15 00:00:00
abstract::Microscopic colitis (MC), which is comprised of lymphocytic colitis and collagenous colitis, is a clinicopathological diagnosis that is commonly encountered in clinical practice during the evaluation and management of chronic diarrhea. With an incidence approaching the incidence of inflammatory bowel disease, physicia...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl17061
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.1.37
更新日期:2011-03-01 00:00:00
abstract:Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18148
更新日期:2018-11-15 00:00:00
abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16033
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.2.95
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl13457
更新日期:2015-09-23 00:00:00
abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl15167
更新日期:2015-11-23 00:00:00
abstract:Background/Aims:Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA; EUS-FNA) allows for diagnostic tissue specimens from various regions to be analyzed. However, diagnosing recurrent pancreaticobiliary cancer after surgery is sometimes difficult. We evaluated the efficacy of EUS-FNA in the diagnosis of loca...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl19200
更新日期:2020-09-15 00:00:00
abstract::Enteropathy-type T-cell lymphoma (ETL) or enteropathy-associated T-cell lymphoma is a very rare malignant intestinal tumor. ETL is usually diagnosed by surgery. Endoscopic findings of ETL are not well known, and there are few reports of findings from endoscopy that has been performed only using white light. Additional...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.4.516
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45,...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15208
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND/AIMS:Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS:A total of 269 gastric hyperplastic polyps from 21...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.4.271
更新日期:2009-12-01 00:00:00
abstract::It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato-oncologic diseases who are undergoing inten...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.3.218
更新日期:2009-09-01 00:00:00
abstract::Acute symptomatic portal vein obstruction related to biliary stenting is an extremely rare but life-threatening complication. This usually occurs in patients with either tumor invasion into the portal vein or pre-existing portal vein thrombus. Therefore, the portal vein should be carefully evaluated before placing a b...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2008.2.1.47
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND/AIMS:The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -neg...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.3.315
更新日期:2011-09-01 00:00:00
abstract::A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13358
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.1.41
更新日期:2009-03-01 00:00:00
abstract::We report a case of malignant fibrous histiocytoma (MFH) of the right buttock with multiple metastases to the lung, bone, and small intestine. He received resection and end-to-end anastomosis of the jejunum for the jejunal metastatic tumor, and mass excision of the metastatic tumor of the left femur followed by closed...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2008.2.3.213
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND/AIMS:The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS:The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15133
更新日期:2015-09-23 00:00:00
abstract::During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding e...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19265
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND/AIMS:To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). METHODS:Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from Novembe...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14391
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND/AIMS:Several precut techniques have been used to gain biliary access for difficult cases. The aim of this study was to evaluate the success and complication rates of two precut techniques, transpancreatic septotomy (TPS) and needle knife infundibulotomy (NKI), in difficult biliary cannulation due to the pres...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14223
更新日期:2015-07-01 00:00:00
abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16078
更新日期:2017-07-15 00:00:00
abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18398
更新日期:2019-09-15 00:00:00
abstract::The goal of antiviral therapy for patients with chronic hepatitis C virus (HCV) infection is to attain a sustained virologic response (SVR), which is defined as undetectable serum HCV-RNA levels at 6 months after the cessation of treatment. Major improvements in antiviral therapy for chronic hepatitis C have occurred ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.117
更新日期:2011-06-01 00:00:00
abstract:Background/Aims:Electrohydraulic lithotripsy (EHL) under endoscopic retrograde cholangiopancreatography (ERCP) guidance can be an option to treat difficult stones. Recently, a digital, single-operator cholangioscope (SPY-DS) has become available. Peroral transluminal cholangioscopy (PTLC) using SPY-DS has also been rep...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17352
更新日期:2018-07-15 00:00:00
abstract:BACKGROUND/AIMS:The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune-mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune-mediated response or neuronal degeneratio...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.4.411
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.1.113
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2007.1.2.138
更新日期:2007-12-01 00:00:00
abstract::Metastasis to the stomach from renal cell carcinoma (RCC) is extremely rare. Usually, gastric metastasis seems to be a late event in patients with RCC and is accompanied by disseminated tumor spread to other organs. Solitary synchronous gastric metastasis from small, localized RCC has rarely been reported. We report a...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.3.388
更新日期:2012-07-01 00:00:00