Helicobacter pylori Treatment Strategies in Singapore.

Abstract:

:The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatment option, with an eradication rate exceeding 90%, although the accepted treatment duration must now be lengthened from 1 to 2 weeks to maintain efficacy. Concomitant and sequential therapies did not demonstrate superiority over standard triple therapy. Current empiric second line treatment utilizes either bismuth-based quadruple therapy or levofloxacin-based triple therapy, but outcomes remain less than ideal. Identifying options to further improve treatment success rates is challenging. Strategies being considered include the use of potent acid suppressants, such as vonoprazan, and H. pylori culture and antibiotic susceptibility testing-guided therapy.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Ang TL,Ang D

doi

10.5009/gnl19308

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

13-18

issue

1

eissn

1976-2283

issn

2005-1212

pii

gnl19308

journal_volume

15

pub_type

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