Biology of Cholangiocytes: From Bench to Bedside.

abstract：BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...

journal_title：Gut and liver

authors： Kim YC,Kim JH,Cheung DY,Kim TH,Jun EJ,Oh JW,Kim CW,Chung WC,Kim BW,Kim SS,Kim JI,Park SH,Kim JK

更新日期：2015-09-23 00:00:00

abstract：:Most colonic lipomas are asymptomatic and need no treatment, whereas lesions larger than 2 cm can cause acute abdominal pain, changes in bowel habits, gastrointestinal bleeding, intussusception or bowel obstruction. Autoamputation of polypoid lesions in the gastrointestinal tract is indeed a rare phenomenon, and its p...

journal_title：Gut and liver

authors： Jeong HK,Cho SB,Seo TJ,Lee KR,Lee WS,Kim HS,Joo YE

更新日期：2011-09-01 00:00:00

abstract：:Metastasis to the stomach from renal cell carcinoma (RCC) is extremely rare. Usually, gastric metastasis seems to be a late event in patients with RCC and is accompanied by disseminated tumor spread to other organs. Solitary synchronous gastric metastasis from small, localized RCC has rarely been reported. We report a...

journal_title：Gut and liver

authors： Kim MY,Jung HY,Choi KD,Song HJ,Lee JH,Kim DH,Choi KS,Kim SA,Lee GH,Kim JH

更新日期：2012-07-01 00:00:00

abstract：:Cholangiocarcinoma is a catastrophic tumor with a high mortality rate, for which surgery is the most reliable treatment. However, these tumors progress insidiously and are difficult to diagnose early. Most patients lack the opportunity to receive surgery due to the advanced disease stage at the time of the diagnosis, ...

journal_title：Gut and liver

authors： Park JS,Lee DH,Jeong S,Kim WC,Lee JI,Lee SY,Park SD,Nha SY

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND/AIMS:Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more...

journal_title：Gut and liver

authors： Hong MJ,Cheon YK,Lee EJ,Lee TY,Shim CS

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND/AIMS:We aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central Iran. METHODS:Sixty-one patients with colorectal adenocarcinoma were enrolled in the study....

journal_title：Gut and liver

authors： Golmohammadi R,Namazi MJ,Nikbakht M,Salehi M,Derakhshan MH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/AIMS:Standard treatments are not available for hilar nonresectable cholangiocarcinoma (NCC). It is unknown whether combination therapy of photodynamic therapy (PDT) plus systemic chemotherapy is superior to PDT alone. METHODS:We retrospectively reviewed 68 patients with hilar NCC treated with either PDT plu...

journal_title：Gut and liver

authors： Wentrup R,Winkelmann N,Mitroshkin A,Prager M,Voderholzer W,Schachschal G,Jürgensen C,Büning C

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...

journal_title：Gut and liver

authors： Yamaoka M,Nakajima S

更新日期：2009-06-01 00:00:00

abstract：Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...

journal_title：Gut and liver

authors： Yanai S,Yamaguchi S,Nakamura S,Kawasaki K,Toya Y,Yamada N,Eizuka M,Uesugi N,Umeno J,Esaki M,Okimoto E,Ishihara S,Sugai T,Matsumoto T

更新日期：2019-01-15 00:00:00

abstract：Background/Aims:Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in ...

journal_title：Gut and liver

authors： Hayashi T,Saitoh S,Fukuzawa K,Tsuji Y,Takahashi J,Kawamura Y,Akuta N,Kobayashi M,Ikeda K,Fujii T,Miyati T,Kumada H

更新日期：2017-09-15 00:00:00

abstract：Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular inv...

journal_title：Gut and liver

authors： Lee SY,Yoshida N,Dohi O,Lee SP,Ichikawa D,Kim JH,Sung IK,Park HS,Otsuji E,Itoh Y,Shim CS,Han HS,Kishimoto M,Naito Y

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...

journal_title：Gut and liver

authors： Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

更新日期：2015-09-23 00:00:00

abstract：:Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications. Apoptosis is recognized relatively easily due to its unique morphology, b...

journal_title：Gut and liver

authors： Aizawa S,Brar G,Tsukamoto H

更新日期：2020-01-15 00:00:00

abstract：BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...

journal_title：Gut and liver

authors： Fukunaga K,Nagase K,Kusaka T,Hida N,Ohda Y,Yoshida K,Tozawa K,Kamikozuru K,Iimuro M,Nakamura S,Miwa H,Matsumoto T

更新日期：2009-03-01 00:00:00

abstract：Background/Aims:Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. py...

journal_title：Gut and liver

authors： Lee JY,Park HW,Choi JY,Lee JS,Koo JE,Chung EJ,Chang HS,Choe J,Yang DH,Myung SJ,Jung HY,Yang SK,Byeon JS

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND/AIMS:Drug-induced liver injury (DILI) is a frequent cause of pediatric liver disease; however, the data on DILI are remarkably limited. METHODS:All 69 children hospitalized with DILI between January 2009 and December 2011 were retrospectively studied. RESULTS:A total of 37.7% of the children had medical hi...

journal_title：Gut and liver

authors： Zhu Y,Li YG,Wang JB,Liu SH,Wang LF,Zhao YL,Bai YF,Wang ZX,Li JY,Xiao XH

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

journal_title：Gut and liver

authors： Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2)....

journal_title：Gut and liver

authors： Lee SW,Ahn YY,Kim YS,Kang SB,Nam SW,Lee DS,Jeong HY,Kim JM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIMS:Benign bronchoesophageal fistula (BEF) is a rare condition that is usually treated surgically; however, less invasive endoscopy procedures have been attempted to overcome the disadvantages of surgery. The aim of this study was thus to determine the results of endoscopic management as a primary treatment...

journal_title：Gut and liver

authors： Ahn JY,Jung HY,Choi JY,Kim MY,Lee JH,Choi KS,Kim DH,Choi KD,Song HJ,Lee GH,Kim JH

更新日期：2010-12-01 00:00:00

abstract：Background/Aims:Although many studies have reported the promising effect of neoadjuvant treatment for borderline resectable pancreatic cancer (BRPC) to increase resectability, only a few studies have recommended the use of firstline chemotherapeutic agents as neoadjuvant treatment for BRPC. The current study compared c...

journal_title：Gut and liver

authors： Choi YJ,Byun Y,Kang JS,Kim HS,Han Y,Kim H,Kwon W,Oh DY,Paik WH,Lee SH,Ryu JK,Kim YT,Lee K,Kim H,Chie EK,Jang JY

更新日期：2020-08-26 00:00:00

abstract：:Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore poses a clinical conundrum. Cur...

journal_title：Gut and liver

authors： di Pietro M,Alzoubaidi D,Fitzgerald RC

更新日期：2014-07-01 00:00:00

abstract：:A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer...

journal_title：Gut and liver

authors： Saito T,Naito M,Matsumura Y,Kita H,Kanno T,Nakada Y,Hamano M,Chiba M,Maeda K,Michida T,Ito T

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45,...

journal_title：Gut and liver

authors： Kim JH,Park JJ,Lee BJ,Joo MK,Chun HJ,Lee SW,Bak YT

更新日期：2016-05-23 00:00:00

abstract：Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...

journal_title：Gut and liver

authors： Bang KB,Park JH

更新日期：2018-11-15 00:00:00

abstract：:The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...

journal_title：Gut and liver

authors： Korean Liver Cancer Study Group (KLCSG).,National Cancer Center, Korea (NCC).

更新日期：2015-05-23 00:00:00

abstract：:Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on ...

journal_title：Gut and liver

authors： Moon DB,Lee SG

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIMS:Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS:A total of 269 gastric hyperplastic polyps from 21...

journal_title：Gut and liver

authors： Han AR,Sung CO,Kim KM,Park CK,Min BH,Lee JH,Kim JY,Chang DK,Kim YH,Rhee PL,Rhee JC,Kim JJ

更新日期：2009-12-01 00:00:00

abstract：Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...

journal_title：Gut and liver

authors： Xu L,Li L,Wang P,Zhang M,Zhang Y,Hao X,Yan L,Li B,Wen T,Xu M

更新日期：2019-11-15 00:00:00

abstract：:Serrated polyps are considered precursor lesions that account for 15% to 30% of colorectal cancers, and they are overrepresented as a cause of interval cancers. They are difficult to detect and resect comprehensively; however, recent data suggest that high definition endoscopy, chromoendoscopy (via spray catheter, pum...

journal_title：Gut and liver

authors： Gupta V,East JE

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND/AIMS:The notion that acute hepatitis A superimposed on chronic hepatitis B infection leads to a worse outcome than acute hepatitis A alone remains controversial. The aim of this study was to determine the influence of the presence of hepatitis B surface antigen (HBsAg) on the severity of acute hepatitis A. ...

journal_title：Gut and liver

authors： Kim KM,Eo SJ,Gwak GY,Choi MS,Lee JH,Koh KC,Yoo BC,Paik SW

更新日期：2011-12-01 00:00:00