Prevalence of subjects at a high or very high risk of gastric cancer in Japan.

Abstract:

BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To determine the prevalence of subjects at a high risk (HpSA+ or PG+) or very high risk (PG+) of gastric cancer in Japan, we applied the two tests to a general population. METHODS:The subjects included 311 volunteers. We used Meridian HpSA ELISA for the HpSA test and Pepsinogen RIA Beads for the PG test. PG I at 50% of those older than 40 years). Half of the subjects older than 60 years were PG+. CONCLUSIONS:In Japan, more than 50% of general population aged >/=40 years is at a high risk of gastric cancer, and half of the population aged >/=60 years is at a very high risk.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Yamaoka M,Nakajima S

doi

10.5009/gnl.2009.3.2.95

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

95-100

issue

2

eissn

1976-2283

issn

2005-1212

journal_volume

3

pub_type

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