Expanding Indications for Liver Transplant: Tumor and Patient Factors.

Abstract:

:During the past few decades, liver transplant has developed from a high-mortality procedure to an almost routine procedure with good survival outcomes. The development of living donor liver transplant has increased the availability of liver grafts, and the scope of indications for liver transplant has been expanding ever since. The aim of this review is to provide an overview of such an expansion of scope. Various criteria have been proposed to expand the eligibility of patients with hepatocellular carcinoma exceeding the Milan criteria for liver transplant. Furthermore, liver transplant is increasingly performed as a treatment modality for cholangiocarcinoma, neuroendocrine liver metastasis and colorectal liver metastasis. The number of elderly patients receiving liver transplant is on the rise. Combined organ transplantation has also been adopted to treat patients with multiple organ failure. Going forward, further development of preoperative noninvasive predictors in tumor, patient and even donor factors is needed to identify patients at risk of poor outcomes and hence optimize patient management.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Chu KK,Wong KH,Chok KS

doi

10.5009/gnl19265

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

19-30

issue

1

eissn

1976-2283

issn

2005-1212

pii

gnl19265

journal_volume

15

pub_type

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