Multimodal oncological therapy comprising stents, brachytherapy, and regional chemotherapy for cholangiocarcinoma.

Abstract:

BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-three patients underwent metallic-stent implantation followed by brachytherapy. Patients were divided into two arms: the intra-arterial chemotherapy arm (IA arm, n=17) consisted of patients treated with locoregional treatment (IA admission of Cisplatin and 5-fluorouracil, or chemoembolization with Lipiodol) and/or systemic chemotherapy, while the systemic chemotherapy arm (IV arm, n=23) included all the other patients, who were treated only with systemic chemotherapy. RESULTS:In total, 78 metal self-expandable stents were placed. Hilar involvement with mass-forming and periductal infiltrating types of CC (84%) was predominant. The average number of percutaneous interventional procedures was 11.61 per patient (range, 4-35). The median overall survival from diagnosis of disease for all patients was 13.5 months (range, 11.0-18.8 months). The median overall survival times were 25.2 months (range, 15.2-31.3 months) and 11.5 months (range, 8.5-12.6 months) in the IA and IV arms, respectively (p<0.05). The 1-, 2-, and 3-year survival rates in the IA and IV arms were 88.2%, 52.9%, and 10.1% and 43.5%, 25.4, and 0%, respectively. There were no major complications (WHO III/IV) due to interventional procedures. CONCLUSIONS:We could reach acceptable prognosis in patients with unresectable CC using complex tailored oncological therapy. However, the main limitations of prolonging survival are performance status, patient compliance and the maintaining of biliary tract patency.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Andrašina T,Válek V,Pánek J,Kala Z,Kiss I,Tuček S,Slampa P

doi

10.5009/gnl.2010.4.S1.S82

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

S82-8

eissn

1976-2283

issn

2005-1212

journal_volume

4 Suppl 1

pub_type

杂志文章
  • Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review.

    abstract::Metastasis to the stomach from renal cell carcinoma (RCC) is extremely rare. Usually, gastric metastasis seems to be a late event in patients with RCC and is accompanied by disseminated tumor spread to other organs. Solitary synchronous gastric metastasis from small, localized RCC has rarely been reported. We report a...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.3.388

    authors: Kim MY,Jung HY,Choi KD,Song HJ,Lee JH,Kim DH,Choi KS,Kim SA,Lee GH,Kim JH

    更新日期:2012-07-01 00:00:00

  • Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.

    abstract:BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14120

    authors: Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2015-09-23 00:00:00

  • Anti-Saccharomyces cerevisiae Antibody in Pediatric Crohn's Disease Patients without Mucosal Healing Is a Useful Marker of Mucosal Damage.

    abstract:Background/Aims:We evaluated whether anti-Saccharomyces cerevisiae antibody (ASCA) titers are associated with diagnostic findings, disease activity, Paris classification phenotypes, and persistence after infliximab (IFX) treatment in children with Crohn's disease (CD). We also investigated the role of ASCA as a predict...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl20212

    authors: Kim MJ,Kim E,Kang B,Lee Y,Kang ES,Choe YH

    更新日期:2020-12-30 00:00:00

  • Barrett's esophagus and cancer risk: how research advances can impact clinical practice.

    abstract::Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), whose incidence has increased sharply in the last 4 decades. The annual conversion rate of BE to cancer is significant, but small. The identification of patients at a higher risk of cancer therefore poses a clinical conundrum. Cur...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl.2014.8.4.356

    authors: di Pietro M,Alzoubaidi D,Fitzgerald RC

    更新日期:2014-07-01 00:00:00

  • Does lymphocytic colitis always present with normal endoscopic findings?

    abstract:BACKGROUND/AIMS:Although normal endoscopic findings are, as a rule, part of the diagnosis of microscopic colitis, sev-eral cases of macroscopic lesions (MLs) have been reported in collagenous colitis, but hardly in lymphocytic colitis (LC). The aim of this study was to investigate the endoscopic, clini-cal, and histopa...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13373

    authors: Park HS,Han DS,Ro YO,Eun CS,Yoo KS

    更新日期:2015-03-01 00:00:00

  • Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.

    abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.475

    authors: Lee JY,Kim JS,Moon JM,Lim SA,Chung W,Lim EH,Lee BJ,Park JJ,Bak YT

    更新日期:2013-07-01 00:00:00

  • Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study.

    abstract:Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18148

    authors: Bang KB,Park JH

    更新日期:2018-11-15 00:00:00

  • A case of enteropathy-type T-cell lymphoma diagnosed by small bowel enteroscopy: a perspective on imaging-enhanced endoscopy.

    abstract::Enteropathy-type T-cell lymphoma (ETL) or enteropathy-associated T-cell lymphoma is a very rare malignant intestinal tumor. ETL is usually diagnosed by surgery. Endoscopic findings of ETL are not well known, and there are few reports of findings from endoscopy that has been performed only using white light. Additional...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.4.516

    authors: Bae JY,Ko BM,Min SK,Lee JC,Lee GW,Yoon LY,Hong SJ,Lee MS,Kim HK

    更新日期:2012-10-01 00:00:00

  • Is health screening beneficial for early detection and prognostic improvement in pancreatic cancer?

    abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the usefulness of health screening for early detection and improved prognosis in pancreatic cancer. METHODS:Between 1995 and 2008, 176,361 examinees visited the Health Promotion Center (HPC). Twenty patients diagnosed with pancreatic cancer were enrolled. During th...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.2.194

    authors: Kim ER,Bae SY,Lee KH,Lee KT,Son HJ,Rhee JC,Lee JK

    更新日期:2011-06-01 00:00:00

  • Liver transplantation.

    abstract::Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.3.145

    authors: Moon DB,Lee SG

    更新日期:2009-09-01 00:00:00

  • Prevalence of subjects at a high or very high risk of gastric cancer in Japan.

    abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.2.95

    authors: Yamaoka M,Nakajima S

    更新日期:2009-06-01 00:00:00

  • Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy.

    abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl19301

    authors: Chang JW,Lee HW,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Kim SU

    更新日期:2021-01-15 00:00:00

  • Visceral obesity as a risk factor for left-sided diverticulitis in Japan: a multicenter retrospective study.

    abstract:BACKGROUND/AIMS:Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.5.532

    authors: Yamada E,Ohkubo H,Higurashi T,Sakai E,Endo H,Takahashi H,Uchida E,Tanida E,Izumi N,Kanesaki A,Hata Y,Matsuura T,Fujisawa N,Komatsu K,Maeda S,Nakajima A

    更新日期:2013-09-01 00:00:00

  • One-Step Transpapillary Balloon Dilation under Cap-Fitted Endoscopy without a Preceding Sphincterotomy for the Removal of Bile Duct Stones in Billroth II Gastrectomy.

    abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.1.113

    authors: Lee TH,Hwang JC,Choi HJ,Moon JH,Cho YD,Yoo BM,Park SH,Kim JH,Kim SJ

    更新日期:2012-01-01 00:00:00

  • Endoscopic and Clinical Factors Affecting the Prognosis of Colorectal Endoscopic Submucosal Dissection-Related Perforation.

    abstract:BACKGROUND/AIMS:Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. METH...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15252

    authors: Kang DU,Choi Y,Lee HS,Lee HJ,Park SH,Yang DH,Yoon SM,Kim KJ,Ye BD,Myung SJ,Yang SK,Kim JH,Byeon JS

    更新日期:2016-05-23 00:00:00

  • Inflammatory myoglandular polyps causing hematochezia.

    abstract::We report herein three cases of inflammatory myoglandular polyp (IMGP) presenting as hematochezia. The polyps had pedunculated, red, and smooth features, and were 12, 12, and 15 mm in diameter and located in the sigmoid colon, transverse colon, and rectum, respectively. Endoscopic polypectomies were performed. Histolo...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.1.146

    authors: Chung SH,Son BK,Park YS,Jo YJ,Kim SH,Jun DW,Cheong ES,Lee WM,Ju JE

    更新日期:2010-03-01 00:00:00

  • Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts.

    abstract:Background/Aims:Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiologica...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18265

    authors: Luo ZL,Cheng L,Wang T,Tang LJ,Tian FZ,Xiang K,Cui L

    更新日期:2019-09-15 00:00:00

  • Effect of biofeedback therapy in constipation according to rectal sensation.

    abstract:BACKGROUND/AIMS:The pathophysiologic mechanism of rectal hyposensitivity (RH) is not well documented, and the significance of RH in biofeedback therapy (BFT) has not been evaluated. Thus, we aimed to assess the effect of BFT in constipated patients according to the presence of RH. METHODS:Five hundred and ninety const...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.2.157

    authors: Ahn JY,Myung SJ,Jung KW,Yang DH,Koo HS,Seo SY,Yoon IJ,Kim KJ,Ye BD,Byeon JS,Jung HY,Yang SK,Kim JH

    更新日期:2013-03-01 00:00:00

  • Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center.

    abstract:Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18489

    authors: Xu L,Li L,Wang P,Zhang M,Zhang Y,Hao X,Yan L,Li B,Wen T,Xu M

    更新日期:2019-11-15 00:00:00

  • Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis.

    abstract::Microscopic colitis (MC), which is comprised of lymphocytic colitis and collagenous colitis, is a clinicopathological diagnosis that is commonly encountered in clinical practice during the evaluation and management of chronic diarrhea. With an incidence approaching the incidence of inflammatory bowel disease, physicia...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl17061

    authors: Gentile N,Yen EF

    更新日期:2018-05-15 00:00:00

  • Gastroparesis Updates on Pathogenesis and Management.

    abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16336

    authors: Liu N,Abell T

    更新日期:2017-09-15 00:00:00

  • Gastrointestinal stent update.

    abstract::The use of self-expanding metallic stents in the upper gastrointestinal tract, placed under radiologic imaging or endoscopic guidance, is the current treatment of choice for the palliation of malignant gastrointestinal outlet obstructions. Advances in metallic stent design and delivery systems have progressed to the s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S19

    authors: Kang SG

    更新日期:2010-09-01 00:00:00

  • Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

    abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.3.338

    authors: Hwangbo Y,Kim HJ,Park JS,Ryu KN,Kim NH,Shim J,Jang JY,Dong SH,Kim BH,Chang YW,Chang R

    更新日期:2010-09-01 00:00:00

  • Cell Death and Liver Disease.

    abstract::Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications. Apoptosis is recognized relatively easily due to its unique morphology, b...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl18486

    authors: Aizawa S,Brar G,Tsukamoto H

    更新日期:2020-01-15 00:00:00

  • Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B.

    abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15426

    authors: Shim JJ,Oh IH,Kim SB,Kim JW,Lee CK,Jang JY,Lee JS,Kim BH

    更新日期:2016-11-15 00:00:00

  • Early Infliximab Yields Superior Long-Term Effects on Linear Growth in Pediatric Crohn's Disease Patients.

    abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17290

    authors: Choi J,Kang B,Kim MJ,Sohn I,Lee HJ,Choe YH

    更新日期:2018-05-15 00:00:00

  • Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer.

    abstract:BACKGROUND/AIMS:The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS:The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15133

    authors: Bae YS,Kim H,Noh SH,Kim H

    更新日期:2015-09-23 00:00:00

  • Ultrasonography for Noninvasive Assessment of Portal Hypertension.

    abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16078

    authors: Maruyama H,Yokosuka O

    更新日期:2017-07-15 00:00:00

  • The Performance of Multiple Transgastric Procedures Using the Natural Orifice Transluminal Endoscopic Surgery Technique: Is Pure NOTES Satisfactory?

    abstract:BACKGROUND/AIMS:Although several groups have demonstrated the usefulness of natural orifice transluminal endoscopic surgery (NOTES), there is still concern about frequent serious adverse events. We performed this study to determine the technical feasibility and safety of pure NOTES with a transgastric approach in a por...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.4.457

    authors: Song TJ,Seo DW,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2012-10-01 00:00:00

  • Clinical efficacy of endoscopic treatment for benign colorectal stricture: balloon dilatation versus stenting.

    abstract:BACKGROUND/AIMS:There has been a lack of research comparing balloon dilatation and self-expandable metal stent (SEMS) placement to determine which is better for long-term clinical outcomes in patients with benign colorectal strictures. We aimed to compare the clinical efficacy and complication rates of balloon dilatati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13326

    authors: Park CH,Yoon JY,Park SJ,Cheon JH,Kim TI,Lee SK,Lee YC,Kim WH,Hong SP

    更新日期:2015-01-01 00:00:00