Abstract:
Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective study included pediatric patients with moderate-to-severe CD, who received a combination therapy with infliximab and azathioprine for at least 3 years and sustained corticosteroid-free remission without loss of response. The z-scores of the growth indicators obtained at the time of diagnosis and annually for 3 years thereafter were compared between the two groups. Results:The early combined immunosuppression group displayed significantly increased linear growth 3 years after diagnosis (p=0.026). A significant difference was also observed in the linear growth 3 years after diagnosis between subgroups of Tanner stages 1-2 (p=0.016). Conclusions:The early introduction of biologics should be considered to improve linear growth in pediatric patients with CD.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Choi J,Kang B,Kim MJ,Sohn I,Lee HJ,Choe YHdoi
10.5009/gnl17290subject
Has Abstractpub_date
2018-05-15 00:00:00pages
255-262issue
3eissn
1976-2283issn
2005-1212pii
gnl17290journal_volume
12pub_type
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