Early Infliximab Yields Superior Long-Term Effects on Linear Growth in Pediatric Crohn's Disease Patients.

Abstract:

Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective study included pediatric patients with moderate-to-severe CD, who received a combination therapy with infliximab and azathioprine for at least 3 years and sustained corticosteroid-free remission without loss of response. The z-scores of the growth indicators obtained at the time of diagnosis and annually for 3 years thereafter were compared between the two groups. Results:The early combined immunosuppression group displayed significantly increased linear growth 3 years after diagnosis (p=0.026). A significant difference was also observed in the linear growth 3 years after diagnosis between subgroups of Tanner stages 1-2 (p=0.016). Conclusions:The early introduction of biologics should be considered to improve linear growth in pediatric patients with CD.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Choi J,Kang B,Kim MJ,Sohn I,Lee HJ,Choe YH

doi

10.5009/gnl17290

subject

Has Abstract

pub_date

2018-05-15 00:00:00

pages

255-262

issue

3

eissn

1976-2283

issn

2005-1212

pii

gnl17290

journal_volume

12

pub_type

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