Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression.

Abstract:

BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45, and SNU-1 were treated with various concentrations of astaxanthin. A cell viability test, cell cycle analysis, and immunoblotting were performed. RESULTS:The viability of each cancer cell line was suppressed by astaxanthin in a dose-dependent manner with significantly decreased proliferation in KATO-III and SNU-1 cells. Astaxanthin increased the number of cells in the G0/G1 phase but reduced the proportion of S phase KATO-III and SNU-1 cells. Phosphorylated extracellular signal-regulated kinase (ERK) was decreased in an inverse dose-dependent correlation with astaxanthin concentration, and the expression of p27(kip-1) increased the KATO-III and SNU-1 cell lines in an astaxanthin dose-dependent manner. CONCLUSIONS:Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27(kip-1).

journal_name

Gut Liver

journal_title

Gut and liver

authors

Kim JH,Park JJ,Lee BJ,Joo MK,Chun HJ,Lee SW,Bak YT

doi

10.5009/gnl15208

subject

Has Abstract

pub_date

2016-05-23 00:00:00

pages

369-74

issue

3

eissn

1976-2283

issn

2005-1212

pii

gnl15208

journal_volume

10

pub_type

杂志文章
  • The Role of Acid Suppressants in the Prevention of Anticoagulant-Related Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis.

    abstract::Background/Aims: Although acid suppressants are widely used for the prevention or treatment of drug-induced upper gastrointestinal bleeding (GIB), evidence regarding the prevention of anticoagulant-related GIB is scarce. The aim of this study was to evaluate the protective effect of acid suppressants against an...

    journal_title:Gut and liver

    pub_type: 杂志文章,meta分析

    doi:10.5009/gnl19009

    authors: Bang CS,Joo MK,Kim BW,Kim JS,Park CH,Ahn JY,Lee JH,Lee BE,Yang HJ,Cho YK,Park JM,Kim BJ,Jung HK,Korean College of Helicobacter and Upper Gastrointestinal Research.

    更新日期:2020-01-15 00:00:00

  • Endoscopic Ultrasound-Guided Hepaticogastrostomy: Technical Review and Tips to Prevent Adverse Events.

    abstract::Most patients who require biliary drainage can be treated by endoscopic retrograde cholangiopancreatography (ERCP)- guided procedures. However, ERCP can be challenging in patients with complications, such as malignant duodenal obstruction, or a surgically-altered anatomy, such as a Rouxen- Y anastomosis, which prevent...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl20096

    authors: Ogura T,Higuchi K

    更新日期:2020-07-23 00:00:00

  • Current Definition of and Controversial Issues Regarding Postoperative Pancreatic Fistulas.

    abstract::The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl18229

    authors: Marchegiani G,Andrianello S,Salvia R,Bassi C

    更新日期:2019-03-15 00:00:00

  • Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to eva...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.2.177

    authors: Lee HJ,Yeon JE,Suh SJ,Lee SJ,Yoon EL,Kang K,Yoo YJ,Kim JH,Seo YS,Yim HJ,Byun KS

    更新日期:2014-03-01 00:00:00

  • Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.

    abstract:Background/Aims:Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18296

    authors: Takajo T,Tomita K,Tsuchihashi H,Enomoto S,Tanichi M,Toda H,Okada Y,Furuhashi H,Sugihara N,Wada A,Horiuchi K,Inaba K,Hanawa Y,Shibuya N,Shirakabe K,Higashiyama M,Kurihara C,Watanabe C,Komoto S,Nagao S,Kimura K,Mi

    更新日期:2019-05-15 00:00:00

  • Alcohol Consumption Can Reduce the Risk of Gallstone Disease: A Systematic Review with a Dose-Response Meta-Analysis of Case-Control and Cohort Studies.

    abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...

    journal_title:Gut and liver

    pub_type: 杂志文章,meta分析

    doi:10.5009/gnl18278

    authors: Cha BH,Jang MJ,Lee SH

    更新日期:2019-01-15 00:00:00

  • Distinction between Chronic Enteropathy Associated with the SLCO2A1 Gene and Crohn's Disease.

    abstract:Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18261

    authors: Yanai S,Yamaguchi S,Nakamura S,Kawasaki K,Toya Y,Yamada N,Eizuka M,Uesugi N,Umeno J,Esaki M,Okimoto E,Ishihara S,Sugai T,Matsumoto T

    更新日期:2019-01-15 00:00:00

  • The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma.

    abstract:BACKGROUND/AIMS:Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2)....

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.1.45

    authors: Lee SW,Ahn YY,Kim YS,Kang SB,Nam SW,Lee DS,Jeong HY,Kim JM

    更新日期:2012-01-01 00:00:00

  • Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan.

    abstract:Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular inv...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl16281

    authors: Lee SY,Yoshida N,Dohi O,Lee SP,Ichikawa D,Kim JH,Sung IK,Park HS,Otsuji E,Itoh Y,Shim CS,Han HS,Kishimoto M,Naito Y

    更新日期:2017-05-15 00:00:00

  • Efficacy and safety of endoscopic submucosal dissection for early gastric cancer in patients with comorbid diseases.

    abstract:BACKGROUND/AIMS:Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.2.186

    authors: Kim BJ,Chang TH,Kim JJ,Min BH,Lee JH,Son HJ,Rhee PL,Rhee JC,Kim KM,Park CK

    更新日期:2010-06-01 00:00:00

  • PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach.

    abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect of the synthetic S-allyl-L-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle con...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15584

    authors: Choi YJ,Kim N,Lee JY,Nam RH,Suh JH,Lee SM,Ham MH,Jo HJ,Shim YK,Park YH,Lee JC,Choi YJ,Lee HS,Lee DH

    更新日期:2016-09-15 00:00:00

  • Analysis of the effects of stent insertion and the factors related to stent retrieval in chronic pancreatitis accompanying main pancreatic duct obstruction.

    abstract:BACKGROUND/AIMS:Obstruction of the main pancreatic duct (MPD) has been considered one of the major causes for pain in chronic pancreatitis (CP). In this study, we evaluated the efficacy of MPD stenting in painful CP, and tried to determine a guideline for stent removal. METHODS:Sixteen patients with painful CP who und...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2007.1.1.63

    authors: Kim CH,Bang S,Song KH,Park JY,Jeon TJ,Hong SP,Chung JB,Park SW,Song SY

    更新日期:2007-06-01 00:00:00

  • Infliximab therapy impacts the peripheral immune system of immunomodulator and corticosteroid naïve patients with Crohn's disease.

    abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.1.37

    authors: Kato K,Fukunaga K,Kamikozuru K,Kashiwamura S,Hida N,Ohda Y,Takeda N,Yoshida K,Iimuro M,Yokoyama Y,Kikuyama R,Miwa H,Matsumoto T

    更新日期:2011-03-01 00:00:00

  • Weight Loss as a Nonpharmacologic Strategy for Erosive Esophagitis: A 5-Year Follow-up Study.

    abstract:Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18148

    authors: Bang KB,Park JH

    更新日期:2018-11-15 00:00:00

  • The Performance of Multiple Transgastric Procedures Using the Natural Orifice Transluminal Endoscopic Surgery Technique: Is Pure NOTES Satisfactory?

    abstract:BACKGROUND/AIMS:Although several groups have demonstrated the usefulness of natural orifice transluminal endoscopic surgery (NOTES), there is still concern about frequent serious adverse events. We performed this study to determine the technical feasibility and safety of pure NOTES with a transgastric approach in a por...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.4.457

    authors: Song TJ,Seo DW,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2012-10-01 00:00:00

  • 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma.

    abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl14460

    authors: Korean Liver Cancer Study Group (KLCSG).,National Cancer Center, Korea (NCC).

    更新日期:2015-05-23 00:00:00

  • Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.

    abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.475

    authors: Lee JY,Kim JS,Moon JM,Lim SA,Chung W,Lim EH,Lee BJ,Park JJ,Bak YT

    更新日期:2013-07-01 00:00:00

  • Quality Metrics of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program in Korea.

    abstract:Background/Aims:Knowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program. Methods:In our screening program, asymptomatic subjects aged ≥...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17030

    authors: Kim DH,Cha JM,Kwak MS,Yoon JY,Cho YH,Jeon JW,Shin HP,Joo KR,Lee JI

    更新日期:2018-03-15 00:00:00

  • Characterization and Prognostic Value of Mutations in Exons 5 and 6 of the p53 Gene in Patients with Colorectal Cancers in Central Iran.

    abstract:BACKGROUND/AIMS:We aimed to investigate the relation-ships among various mutations of the p53 gene and their protein products, histological characteristics, and disease prognosis of primary colorectal cancer in Isfahan, central Iran. METHODS:Sixty-one patients with colorectal adenocarcinoma were enrolled in the study....

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.3.295

    authors: Golmohammadi R,Namazi MJ,Nikbakht M,Salehi M,Derakhshan MH

    更新日期:2013-05-01 00:00:00

  • Gastrointestinal stent update.

    abstract::The use of self-expanding metallic stents in the upper gastrointestinal tract, placed under radiologic imaging or endoscopic guidance, is the current treatment of choice for the palliation of malignant gastrointestinal outlet obstructions. Advances in metallic stent design and delivery systems have progressed to the s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S19

    authors: Kang SG

    更新日期:2010-09-01 00:00:00

  • Helicobacter pylori Treatment Strategies in Singapore.

    abstract::The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatm...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19308

    authors: Ang TL,Ang D

    更新日期:2021-01-15 00:00:00

  • Optimal Endoscopic Treatment and Surveillance of Serrated Polyps.

    abstract::Serrated polyps are considered precursor lesions that account for 15% to 30% of colorectal cancers, and they are overrepresented as a cause of interval cancers. They are difficult to detect and resect comprehensively; however, recent data suggest that high definition endoscopy, chromoendoscopy (via spray catheter, pum...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19202

    authors: Gupta V,East JE

    更新日期:2020-07-15 00:00:00

  • Clinical efficacy of endoscopic treatment for benign colorectal stricture: balloon dilatation versus stenting.

    abstract:BACKGROUND/AIMS:There has been a lack of research comparing balloon dilatation and self-expandable metal stent (SEMS) placement to determine which is better for long-term clinical outcomes in patients with benign colorectal strictures. We aimed to compare the clinical efficacy and complication rates of balloon dilatati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13326

    authors: Park CH,Yoon JY,Park SJ,Cheon JH,Kim TI,Lee SK,Lee YC,Kim WH,Hong SP

    更新日期:2015-01-01 00:00:00

  • Ultrasonography for Noninvasive Assessment of Portal Hypertension.

    abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16078

    authors: Maruyama H,Yokosuka O

    更新日期:2017-07-15 00:00:00

  • Peritoneal dissemination from malignant fibrous histiocytoma of the buttock: unusual metastases from a rare tumor.

    abstract::We report a case of malignant fibrous histiocytoma (MFH) of the right buttock with multiple metastases to the lung, bone, and small intestine. He received resection and end-to-end anastomosis of the jejunum for the jejunal metastatic tumor, and mass excision of the metastatic tumor of the left femur followed by closed...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2008.2.3.213

    authors: Yoo JW,Lee DH,Song HJ,Ahn JH,Kim SW,Suh C,Lee JS

    更新日期:2008-12-01 00:00:00

  • Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

    abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14018

    authors: Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2015-01-01 00:00:00

  • Liver transplantation.

    abstract::Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.3.145

    authors: Moon DB,Lee SG

    更新日期:2009-09-01 00:00:00

  • Causes, Features, and Outcomes of Drug-Induced Liver Injury in 69 Children from China.

    abstract:BACKGROUND/AIMS:Drug-induced liver injury (DILI) is a frequent cause of pediatric liver disease; however, the data on DILI are remarkably limited. METHODS:All 69 children hospitalized with DILI between January 2009 and December 2011 were retrospectively studied. RESULTS:A total of 37.7% of the children had medical hi...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14184

    authors: Zhu Y,Li YG,Wang JB,Liu SH,Wang LF,Zhao YL,Bai YF,Wang ZX,Li JY,Xiao XH

    更新日期:2015-07-01 00:00:00

  • Portal vein occlusion after biliary metal stent placement in hilar cholangiocarcinoma.

    abstract::Acute symptomatic portal vein obstruction related to biliary stenting is an extremely rare but life-threatening complication. This usually occurs in patients with either tumor invasion into the portal vein or pre-existing portal vein thrombus. Therefore, the portal vein should be carefully evaluated before placing a b...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2008.2.1.47

    authors: Woo KH,Kim JB,Chang YJ,Kim HJ,Baek IH,Ko JS,Woo JY,Kim HD,Lee MS

    更新日期:2008-06-01 00:00:00

  • Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin.

    abstract::Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of clinical investigations and molecular pathological analyses of the roles of H. pylori eradication and ...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19079

    authors: Watari J,Tomita T,Tozawa K,Oshima T,Fukui H,Miwa H

    更新日期:2020-05-15 00:00:00