Long-Term Effects of Helicobacter pylori Eradication on Metachronous Gastric Cancer Development.

Abstract:

Background/Aims:Gastric mucosal atrophy and intestinal metaplasia due to Helicobacter pylori infection are the main precursor lesions of gastric cancer. The aim of this study was to evaluate the long-term effects of H. pylori eradication on the progression of precancerous lesions to metachronous cancer after endoscopic resection of early gastric cancer (EGC). Methods:Patients who underwent endoscopic resection of EGC were retrospectively reviewed. Changes in precancerous lesions and development of metachronous cancer were compared according to H. pylori eradication and final infection status. Results:In total, 565 patients were followed for over 5 years after endoscopic resection of EGC. The grade of atrophy on corpus was significantly lower in the H. pylori-eradicated group than in the persistent group during follow-up (p=0.029). In patients <70 years of age, the cumulative incidence rate of metachronous cancer was significantly lower in the H. pylori-eradicated group than in the persistent group (p=0.018). Age was an independent risk factor for metachronous cancer development. Conclusions:H. pylori eradication might prevent the development of metachronous cancer in patients <70 years of age by delaying the progression of precancerous lesions after endoscopic resection of EGC.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Han SJ,Kim SG,Lim JH,Choi JM,Oh S,Park JY,Kim J,Kim JS,Jung HC

doi

10.5009/gnl17073

subject

Has Abstract

pub_date

2018-03-15 00:00:00

pages

133-141

issue

2

eissn

1976-2283

issn

2005-1212

pii

gnl17073

journal_volume

12

pub_type

杂志文章
  • Learning curves for colonoscopy: a prospective evaluation of gastroenterology fellows at a single center.

    abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.1.31

    authors: Chung JI,Kim N,Um MS,Kang KP,Lee D,Na JC,Lee ES,Chung YM,Won JY,Lee KH,Nam TM,Lee JH,Choi HC,Lee SH,Park YS,Hwang JH,Kim JW,Jeong SH,Lee DH

    更新日期:2010-03-01 00:00:00

  • Proteomic identification of proteins suggestive of immune-mediated response or neuronal degeneration in serum of achalasia patients.

    abstract:BACKGROUND/AIMS:The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune-mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune-mediated response or neuronal degeneratio...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.411

    authors: Im SK,Yeo M,Lee KJ

    更新日期:2013-07-01 00:00:00

  • Importance of the time interval between bowel preparation and colonoscopy in determining the quality of bowel preparation for full-dose polyethylene glycol preparation.

    abstract:BACKGROUND/AIMS:The quality of bowel preparation (QBP) is the important factor in performing a successful colonoscopy. Several factors influencing QBP have been reported; however, some factors, such as the optimal preparation-to-colonoscopy time interval, remain controversial. This study aimed to determine the factors ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13228

    authors: Kim TK,Kim HW,Kim SJ,Ha JK,Jang HH,Hong YM,Park SB,Choi CW,Kang DH

    更新日期:2014-11-01 00:00:00

  • Long-term outcome of photodynamic therapy with systemic chemotherapy compared to photodynamic therapy alone in patients with advanced hilar cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.3.318

    authors: Hong MJ,Cheon YK,Lee EJ,Lee TY,Shim CS

    更新日期:2014-05-01 00:00:00

  • Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

    abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.3.338

    authors: Hwangbo Y,Kim HJ,Park JS,Ryu KN,Kim NH,Shim J,Jang JY,Dong SH,Kim BH,Chang YW,Chang R

    更新日期:2010-09-01 00:00:00

  • Rapidly progressive hepatocellular carcinoma mimicking benign portal vein thrombosis: a case report.

    abstract::Portal vein thrombosis (PVT) is commonly associated with liver cirrhosis, irrespective of the presence of hepatocellular carcinoma (HCC). Given that malignant PVT is a poor prognostic factor in patients with HCC, it is important to differentiate malignant PVT from benign PVT. Because malignant PVT has been reported to...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.1.116

    authors: Kim JW,Lee BC,Shin SS,Heo SH,Lim HS,Jeong YY,Kang HK,Hur YH,Choi YD

    更新日期:2013-01-01 00:00:00

  • Infliximab versus Cyclosporine Treatment for Severe Corticosteroid-Refractory Ulcerative Colitis: A Korean, Retrospective, Single Center Study.

    abstract:BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14120

    authors: Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2015-09-23 00:00:00

  • Risk factors of post endoscopic retrograde cholangiopancreatography bacteremia.

    abstract:BACKGROUND/AIMS:Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study was to investigate the risk factors of post-ERCP bacteremia. METHODS:Among patients who underwen...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.2.228

    authors: Kwak MS,Jang ES,Ryu JK,Kim YT,Yoon YB,Park JK

    更新日期:2013-03-01 00:00:00

  • Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease.

    abstract:Background/Aims:Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl16440

    authors: Hayashi T,Saitoh S,Fukuzawa K,Tsuji Y,Takahashi J,Kawamura Y,Akuta N,Kobayashi M,Ikeda K,Fujii T,Miyati T,Kumada H

    更新日期:2017-09-15 00:00:00

  • Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis.

    abstract::Microscopic colitis (MC), which is comprised of lymphocytic colitis and collagenous colitis, is a clinicopathological diagnosis that is commonly encountered in clinical practice during the evaluation and management of chronic diarrhea. With an incidence approaching the incidence of inflammatory bowel disease, physicia...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl17061

    authors: Gentile N,Yen EF

    更新日期:2018-05-15 00:00:00

  • The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy.

    abstract:BACKGROUND/AIMS:Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS:A total of 269 gastric hyperplastic polyps from 21...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.4.271

    authors: Han AR,Sung CO,Kim KM,Park CK,Min BH,Lee JH,Kim JY,Chang DK,Kim YH,Rhee PL,Rhee JC,Kim JJ

    更新日期:2009-12-01 00:00:00

  • Primary squamous cell carcinoma of the liver initially presenting with pseudoachalasia.

    abstract::Pseudoachalasia secondary to primary squamous cell carcinoma (SCC) of the liver is extremely rare and has not been reported until now. Here, we report a unique case of primary SCC of the liver initially presenting with progressive dysphagia along with short periods of significant weight loss. A 58-year-old man initial...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.2.275

    authors: Choi MK,Kim GH,Song GA,Nam HS,Yi YS,Ahn KH,Kim S,Kim JY,Park DY

    更新日期:2012-04-01 00:00:00

  • Diagnostic dilemma in an unusual case of common bile duct obstruction.

    abstract::Biliary obstructions are rarely caused by a foreign body and have received sparse attention. We present an unusual case with pruritis and abdominal pain caused by impacted full length surgical gauze within the common bile duct. The patient had previously undergone an open cholecystectomy. Radiological investigations w...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.2.245

    authors: Bhandari V,Singh M,Vyas HG,Sharma N,Chejara R

    更新日期:2011-06-01 00:00:00

  • Autoamputation of a giant colonic lipoma.

    abstract::Most colonic lipomas are asymptomatic and need no treatment, whereas lesions larger than 2 cm can cause acute abdominal pain, changes in bowel habits, gastrointestinal bleeding, intussusception or bowel obstruction. Autoamputation of polypoid lesions in the gastrointestinal tract is indeed a rare phenomenon, and its p...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.3.380

    authors: Jeong HK,Cho SB,Seo TJ,Lee KR,Lee WS,Kim HS,Joo YE

    更新日期:2011-09-01 00:00:00

  • Functional Dyspepsia: Advances in Diagnosis and Therapy.

    abstract::Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; compris...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16055

    authors: Talley NJ

    更新日期:2017-05-15 00:00:00

  • Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to eva...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.2.177

    authors: Lee HJ,Yeon JE,Suh SJ,Lee SJ,Yoon EL,Kang K,Yoo YJ,Kim JH,Seo YS,Yim HJ,Byun KS

    更新日期:2014-03-01 00:00:00

  • Gastroparesis Updates on Pathogenesis and Management.

    abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16336

    authors: Liu N,Abell T

    更新日期:2017-09-15 00:00:00

  • Is the Reinitiation of Antiplatelet Agents Safe at 1 Week after Gastric Endoscopic Submucosal Dissection? Assessment of Bleeding Risk Using the Forrest Classification.

    abstract:Background/Aims:Delayed bleeding after gastric endoscopic submucosal dissection (ESD) commonly occurs within 3 days, but it may also occur after 1 week following ESD, especially in antiplatelet agent users. We evaluated the risk of delayed bleeding in post-ESD ulcers using the Forrest classification. Methods:Registry ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl16232

    authors: Lee JY,Kim CG,Cho SJ,Kim YI,Choi IJ

    更新日期:2017-07-15 00:00:00

  • Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?

    abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2007.1.2.138

    authors: Lim SH,Kim DH,Park MJ,Kim YS,Kim CH,Yim JY,Cho KR,Kim SS,Choi SH,Kim N,Cho SH,Oh BH

    更新日期:2007-12-01 00:00:00

  • Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy.

    abstract:Background/Aims:Although forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignanc...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18006

    authors: Kim MS,Kim SG,Chung H,Kim J,Hong H,Lee HJ,Kim HJ,Kim MA,Kim WH,Jung HC

    更新日期:2018-09-15 00:00:00

  • Current Definition of and Controversial Issues Regarding Postoperative Pancreatic Fistulas.

    abstract::The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl18229

    authors: Marchegiani G,Andrianello S,Salvia R,Bassi C

    更新日期:2019-03-15 00:00:00

  • Alcohol Consumption Can Reduce the Risk of Gallstone Disease: A Systematic Review with a Dose-Response Meta-Analysis of Case-Control and Cohort Studies.

    abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...

    journal_title:Gut and liver

    pub_type: 杂志文章,meta分析

    doi:10.5009/gnl18278

    authors: Cha BH,Jang MJ,Lee SH

    更新日期:2019-01-15 00:00:00

  • Anti-Saccharomyces cerevisiae Antibody in Pediatric Crohn's Disease Patients without Mucosal Healing Is a Useful Marker of Mucosal Damage.

    abstract:Background/Aims:We evaluated whether anti-Saccharomyces cerevisiae antibody (ASCA) titers are associated with diagnostic findings, disease activity, Paris classification phenotypes, and persistence after infliximab (IFX) treatment in children with Crohn's disease (CD). We also investigated the role of ASCA as a predict...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl20212

    authors: Kim MJ,Kim E,Kang B,Lee Y,Kang ES,Choe YH

    更新日期:2020-12-30 00:00:00

  • Proton pump inhibitor use before percutaneous endoscopic gastrostomy is associated with adverse outcomes.

    abstract:BACKGROUND/AIMS:Knowledge of the risk factors associated with adverse outcomes after percutaneous endoscopic gastrostomy (PEG) may be helpful for developing PEG recommendations. The purpose of this study was to identify the clinical risk factors associated with adverse clinical outcomes after PEG, especially regarding ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.3.248

    authors: Im JP,Cha JM,Kim JW,Kim SE,Ryu DY,Kim EY,Kim ER,Chang DK

    更新日期:2014-05-01 00:00:00

  • National Endoscopy Quality Improvement Program Remains Suboptimal in Korea.

    abstract:BACKGROUND/AIMS:We evaluated the characteristics of the National Cancer Screening Program (NCSP) and opinions regarding the National Endoscopy Quality Improvement Program (NEQIP). METHODS:We surveyed physicians performing esophagogastroduodenoscopy and/or colonoscopy screenings as part of the NCSP via e-mail between J...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15623

    authors: Cha JM,Moon JS,Chung IK,Kim JO,Im JP,Cho YK,Kim HG,Lee SK,Lee HL,Jang JY,Kim ES,Jung Y,Moon CM,Kim Y,Park BY

    更新日期:2016-09-15 00:00:00

  • Emerging therapies for hepatitis C.

    abstract::The combination of pegylated interferon (PEG-IFN) and ribavirin (RBV), the current therapy for hepatitis C virus (HCV) infection, has saved the lives of many HCV-infected patients. Direct-acting antivirals (DAAs) target several sites of HCV nonstructural proteins, resulting in the cessation of viral replication. The f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl14083

    authors: Kim DY,Ahn SH,Han KH

    更新日期:2014-09-01 00:00:00

  • Gastrointestinal stent update.

    abstract::The use of self-expanding metallic stents in the upper gastrointestinal tract, placed under radiologic imaging or endoscopic guidance, is the current treatment of choice for the palliation of malignant gastrointestinal outlet obstructions. Advances in metallic stent design and delivery systems have progressed to the s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S19

    authors: Kang SG

    更新日期:2010-09-01 00:00:00

  • Factors Influencing the Diagnostic Accuracy of Acoustic Radiation Force Impulse Elastography in Patients with Chronic Hepatitis B.

    abstract:BACKGROUND/AIMS:To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). METHODS:Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from Novembe...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl14391

    authors: Park MS,Kim SW,Yoon KT,Kim SU,Park SY,Tak WY,Kweon YO,Cho M,Kim BK,Park JY,Kim DY,Ahn SH,Han KH

    更新日期:2016-03-01 00:00:00

  • Navigating the Microbial Basis of Inflammatory Bowel Diseases: Seeing the Light at the End of the Tunnel.

    abstract::Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease deve...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl15491

    authors: Raffals LE,Chang EB

    更新日期:2016-07-15 00:00:00

  • Clinical efficacy of endoscopic treatment for benign colorectal stricture: balloon dilatation versus stenting.

    abstract:BACKGROUND/AIMS:There has been a lack of research comparing balloon dilatation and self-expandable metal stent (SEMS) placement to determine which is better for long-term clinical outcomes in patients with benign colorectal strictures. We aimed to compare the clinical efficacy and complication rates of balloon dilatati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13326

    authors: Park CH,Yoon JY,Park SJ,Cheon JH,Kim TI,Lee SK,Lee YC,Kim WH,Hong SP

    更新日期:2015-01-01 00:00:00