Functional Dyspepsia: Advances in Diagnosis and Therapy.

Abstract:

:Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; comprising early satiety or meal-related fullness) and epigastric pain syndrome. Symptoms of gastroesophageal reflux disease overlap with FD more than expected by chance; a subset has pathological acid reflux. The pretest probability of FD in a patient who presents with classical FD symptoms and no alarm features is high, approximately 0.7. Coexistent heartburn should not lead to the exclusion of FD as a diagnosis. One of the most exciting observations in FD has been the consistent finding of increased duodenal eosinophilia, notably in PDS. Small bowel homing T cells, signaling intestinal inflammation, and increased cytokines have been detected in the circulation, and elevated tumor necrosis factor-α levels have been significantly correlated with increased anxiety. Postinfectious gastroenteritis is a risk factor for FD. Therapeutic options remain limited and provide only symptomatic benefit in most cases. Only one therapy is known to change the natural history of FD-Helicobacter pylori eradication. Treatment of duodenal eosinophilia is under investigation.

journal_name

Gut Liver

journal_title

Gut and liver

authors

Talley NJ

doi

10.5009/gnl16055

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

349-357

issue

3

eissn

1976-2283

issn

2005-1212

pii

gnl16055

journal_volume

11

pub_type

杂志文章,评审
  • The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy.

    abstract:BACKGROUND/AIMS:Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS:A total of 269 gastric hyperplastic polyps from 21...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.4.271

    authors: Han AR,Sung CO,Kim KM,Park CK,Min BH,Lee JH,Kim JY,Chang DK,Kim YH,Rhee PL,Rhee JC,Kim JJ

    更新日期:2009-12-01 00:00:00

  • Ultrasonography for Noninvasive Assessment of Portal Hypertension.

    abstract::Portal hypertension is a major pathophysiology in patients with cirrhosis. Portal pressure is the gold standard to evaluate the severity of portal hypertension, and radiological intervention is the only procedure for pressure measurement. Ultrasound (US) is a simple and noninvasive imaging modality available worldwide...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16078

    authors: Maruyama H,Yokosuka O

    更新日期:2017-07-15 00:00:00

  • Predictive Factors for Severe Outcomes in Ischemic Colitis.

    abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl15167

    authors: Choi SR,Jee SR,Song GA,Park SJ,Lee JH,Song CS,Park HU

    更新日期:2015-11-23 00:00:00

  • Efficacy and safety of endoscopic submucosal dissection for early gastric cancer in patients with comorbid diseases.

    abstract:BACKGROUND/AIMS:Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.2.186

    authors: Kim BJ,Chang TH,Kim JJ,Min BH,Lee JH,Son HJ,Rhee PL,Rhee JC,Kim KM,Park CK

    更新日期:2010-06-01 00:00:00

  • Knowledge Gaps among Physicians Caring for Multiethnic Populations at Increased Gastric Cancer Risk.

    abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl17091

    authors: Shah SC,Itzkowitz SH,Jandorf L

    更新日期:2018-01-15 00:00:00

  • Alcohol Consumption Can Reduce the Risk of Gallstone Disease: A Systematic Review with a Dose-Response Meta-Analysis of Case-Control and Cohort Studies.

    abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...

    journal_title:Gut and liver

    pub_type: 杂志文章,meta分析

    doi:10.5009/gnl18278

    authors: Cha BH,Jang MJ,Lee SH

    更新日期:2019-01-15 00:00:00

  • Room for Quality Improvement in Endoscopist-Directed Sedation: Results from the First Nationwide Survey in Korea.

    abstract:BACKGROUND/AIMS:This study sought to characterize the current sedation practices of Korean endoscopists in real-world settings. METHODS:All active members of the Korean Society of Gastrointestinal Endoscopy were invited to complete an anonymous 35-item questionnaire. RESULTS:The overall response rate was 22.7% (1,332...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15343

    authors: Lee CK,Dong SH,Kim ES,Moon SH,Park HJ,Yang DH,Yoo YC,Lee TH,Lee SK,Hyun JJ,Korean Society of Gastrointestinal Endoscopy Task Force on Endoscopic Sedation.

    更新日期:2016-01-01 00:00:00

  • A case of esophageal intramural pseudodiverticulosis.

    abstract::Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flask-shaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic findings include dilatation of excretory ducts of submucosal glands. The predominant symptom is dysphagia...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.1.93

    authors: Chon YE,Hwang S,Jung KS,Lee HJ,Lee SG,Shin SK,Lee YC

    更新日期:2011-03-01 00:00:00

  • Use of antithrombin and thrombomodulin in the management of disseminated intravascular coagulation in patients with acute cholangitis.

    abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.3.363

    authors: Nakahara K,Okuse C,Adachi S,Suetani K,Kitagawa S,Okano M,Michikawa Y,Takagi R,Shigefuku R,Itoh F

    更新日期:2013-05-01 00:00:00

  • Factors affecting tumor ablation during high intensity focused ultrasound treatment.

    abstract:BACKGROUND/AIMS:High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. METHODS:HIFU was ...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.4.433

    authors: Hassanuddin A,Choi JH,Seo DW,Ryu CH,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2014-07-01 00:00:00

  • Helicobacter pylori Treatment Strategies in Singapore.

    abstract::The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatm...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl19308

    authors: Ang TL,Ang D

    更新日期:2021-01-15 00:00:00

  • Biology of Cholangiocytes: From Bench to Bedside.

    abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16033

    authors: Yoo KS,Lim WT,Choi HS

    更新日期:2016-09-15 00:00:00

  • The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test.

    abstract:BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...

    journal_title:Gut and liver

    pub_type: 杂志文章,多中心研究

    doi:10.5009/gnl13457

    authors: Kim YC,Kim JH,Cheung DY,Kim TH,Jun EJ,Oh JW,Kim CW,Chung WC,Kim BW,Kim SS,Kim JI,Park SH,Kim JK

    更新日期:2015-09-23 00:00:00

  • Fatal Neutropenic Enterocolitis during Pegylated Interferon and Ribavirin Combination Therapy for Chronic Hepatitis C Virus Infection.

    abstract::It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato-oncologic diseases who are undergoing inten...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2009.3.3.218

    authors: Kim JH,Jang JW,You CR,You SY,Jung MK,Jung JH

    更新日期:2009-09-01 00:00:00

  • Clinical Implication and Risk Factors for Malignancy of Atypical Gastric Gland during Forceps Biopsy.

    abstract:Background/Aims:Although forceps biopsy is performed for suspicious gastric tumors during endoscopy, it is difficult to determine treatment strategies for atypical gastric glands due to uncertainty of the diagnosis. The aim of this study was to investigate clinical implications and risk factors for predicting malignanc...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18006

    authors: Kim MS,Kim SG,Chung H,Kim J,Hong H,Lee HJ,Kim HJ,Kim MA,Kim WH,Jung HC

    更新日期:2018-09-15 00:00:00

  • 2014 KLCSG-NCC Korea Practice Guideline for the Management of Hepatocellular Carcinoma.

    abstract::The guideline for the management of hepatocellular carcinoma (HCC) was first developed in 2003 and revised in 2009 by the Korean Liver Cancer Study Group and the National Cancer Center, Korea. Since then, many studies on HCC have been carried out in Korea and other countries. In particular, a substantial body of knowl...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引

    doi:10.5009/gnl14460

    authors: Korean Liver Cancer Study Group (KLCSG).,National Cancer Center, Korea (NCC).

    更新日期:2015-05-23 00:00:00

  • Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.

    abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.4.475

    authors: Lee JY,Kim JS,Moon JM,Lim SA,Chung W,Lim EH,Lee BJ,Park JJ,Bak YT

    更新日期:2013-07-01 00:00:00

  • Clinical efficacy of endoscopic treatment for benign colorectal stricture: balloon dilatation versus stenting.

    abstract:BACKGROUND/AIMS:There has been a lack of research comparing balloon dilatation and self-expandable metal stent (SEMS) placement to determine which is better for long-term clinical outcomes in patients with benign colorectal strictures. We aimed to compare the clinical efficacy and complication rates of balloon dilatati...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl13326

    authors: Park CH,Yoon JY,Park SJ,Cheon JH,Kim TI,Lee SK,Lee YC,Kim WH,Hong SP

    更新日期:2015-01-01 00:00:00

  • Bile Acid Transporters Are Expressed and Heterogeneously Distributed in Rat Bile Ducts.

    abstract:Background/Aims:Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiologica...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18265

    authors: Luo ZL,Cheng L,Wang T,Tang LJ,Tian FZ,Xiang K,Cui L

    更新日期:2019-09-15 00:00:00

  • Gastroparesis Updates on Pathogenesis and Management.

    abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl16336

    authors: Liu N,Abell T

    更新日期:2017-09-15 00:00:00

  • Multimodal oncological therapy comprising stents, brachytherapy, and regional chemotherapy for cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.S1.S82

    authors: Andrašina T,Válek V,Pánek J,Kala Z,Kiss I,Tuček S,Slampa P

    更新日期:2010-09-01 00:00:00

  • Benign bronchoesophageal fistula in adults: endoscopic closure as primary treatment.

    abstract:BACKGROUND/AIMS:Benign bronchoesophageal fistula (BEF) is a rare condition that is usually treated surgically; however, less invasive endoscopy procedures have been attempted to overcome the disadvantages of surgery. The aim of this study was thus to determine the results of endoscopic management as a primary treatment...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2010.4.4.508

    authors: Ahn JY,Jung HY,Choi JY,Kim MY,Lee JH,Choi KS,Kim DH,Choi KD,Song HJ,Lee GH,Kim JH

    更新日期:2010-12-01 00:00:00

  • Effect of Citric Acid on Accuracy of 13C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis.

    abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl18398

    authors: Kwon YH,Kim N,Yoon H,Shin CM,Park YS,Lee DH

    更新日期:2019-09-15 00:00:00

  • Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B.

    abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl15426

    authors: Shim JJ,Oh IH,Kim SB,Kim JW,Lee CK,Jang JY,Lee JS,Kim BH

    更新日期:2016-11-15 00:00:00

  • Rapidly progressive hepatocellular carcinoma mimicking benign portal vein thrombosis: a case report.

    abstract::Portal vein thrombosis (PVT) is commonly associated with liver cirrhosis, irrespective of the presence of hepatocellular carcinoma (HCC). Given that malignant PVT is a poor prognostic factor in patients with HCC, it is important to differentiate malignant PVT from benign PVT. Because malignant PVT has been reported to...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2013.7.1.116

    authors: Kim JW,Lee BC,Shin SS,Heo SH,Lim HS,Jeong YY,Kang HK,Hur YH,Choi YD

    更新日期:2013-01-01 00:00:00

  • Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis.

    abstract::Microscopic colitis (MC), which is comprised of lymphocytic colitis and collagenous colitis, is a clinicopathological diagnosis that is commonly encountered in clinical practice during the evaluation and management of chronic diarrhea. With an incidence approaching the incidence of inflammatory bowel disease, physicia...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审

    doi:10.5009/gnl17061

    authors: Gentile N,Yen EF

    更新日期:2018-05-15 00:00:00

  • The Immunohistochemical Expression of STAT3, Bcl-xL, and MMP-2 Proteins in Colon Adenoma and Adenocarcinoma.

    abstract:BACKGROUND/AIMS:Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2)....

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2012.6.1.45

    authors: Lee SW,Ahn YY,Kim YS,Kang SB,Nam SW,Lee DS,Jeong HY,Kim JM

    更新日期:2012-01-01 00:00:00

  • Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to eva...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2014.8.2.177

    authors: Lee HJ,Yeon JE,Suh SJ,Lee SJ,Yoon EL,Kang K,Yoo YJ,Kim JH,Seo YS,Yim HJ,Byun KS

    更新日期:2014-03-01 00:00:00

  • Analysis of the effects of stent insertion and the factors related to stent retrieval in chronic pancreatitis accompanying main pancreatic duct obstruction.

    abstract:BACKGROUND/AIMS:Obstruction of the main pancreatic duct (MPD) has been considered one of the major causes for pain in chronic pancreatitis (CP). In this study, we evaluated the efficacy of MPD stenting in painful CP, and tried to determine a guideline for stent removal. METHODS:Sixteen patients with painful CP who und...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2007.1.1.63

    authors: Kim CH,Bang S,Song KH,Park JY,Jeon TJ,Hong SP,Chung JB,Park SW,Song SY

    更新日期:2007-06-01 00:00:00

  • Autoamputation of a giant colonic lipoma.

    abstract::Most colonic lipomas are asymptomatic and need no treatment, whereas lesions larger than 2 cm can cause acute abdominal pain, changes in bowel habits, gastrointestinal bleeding, intussusception or bowel obstruction. Autoamputation of polypoid lesions in the gastrointestinal tract is indeed a rare phenomenon, and its p...

    journal_title:Gut and liver

    pub_type: 杂志文章

    doi:10.5009/gnl.2011.5.3.380

    authors: Jeong HK,Cho SB,Seo TJ,Lee KR,Lee WS,Kim HS,Joo YE

    更新日期:2011-09-01 00:00:00