Abstract:
BACKGROUND/AIMS:Aging gastric mucosa is known to have decreased mucosal defenses and increased susceptibility to injury by nonsteroidal anti-inflammatory drugs. Depending on the type of nonsteroidal anti-inflammatory drug (NSAID), the underlying mechanisms and the extent of damage to the stomach or intestine may differ. This study was performed to evaluate the acute gastric damage caused by different doses of indomethacin, diclofenac and aspirin in rats of various ages. METHODS:For the acute models, indomethacin (10, 20 or 40 mg/kg), diclofenac (40 or 80 mg/kg) or aspirin (100 mg/kg) was given to 7- and 25-week-old and 1-year-old Sprague-Dawley rats by intragastric gavage. The gross ulcer index, damage area as assessed by imaging, histological index, myeloperoxidase (MPO) activity, and cytosolic phospholipase A(2) (cPLA(2)) levels were measured after 24 hours. RESULTS:The gross ulcer index and damage area increased with age in the presence of three NSAIDs (p<0.05). The increases in MPO levels induced by diclofenac and aspirin were significantly higher in 1-year-old than 7-week-old rats (p<0.05). cPLA(2) expression induced by indomethacin (10 and 40 mg/kg) was greater in the 1-year-old rats, compared with 7-week-old rats (p<0.05). CONCLUSIONS:NSAID-induced acute gastric damage increased in a dose- and age-dependent manner.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Seo PJ,Kim N,Kim JH,Lee BH,Nam RH,Lee HS,Park JH,Lee MK,Chang H,Jung HC,Song ISdoi
10.5009/gnl.2012.6.2.210subject
Has Abstractpub_date
2012-04-01 00:00:00pages
210-7issue
2eissn
1976-2283issn
2005-1212journal_volume
6pub_type
杂志文章相关文献
Gut and Liver文献大全abstract::We report herein three cases of inflammatory myoglandular polyp (IMGP) presenting as hematochezia. The polyps had pedunculated, red, and smooth features, and were 12, 12, and 15 mm in diameter and located in the sigmoid colon, transverse colon, and rectum, respectively. Endoscopic polypectomies were performed. Histolo...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.146
更新日期:2010-03-01 00:00:00
abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17290
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND/AIMS:Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects. M...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.4.432
更新日期:2011-12-01 00:00:00
abstract::Portal vein thrombosis (PVT) is commonly associated with liver cirrhosis, irrespective of the presence of hepatocellular carcinoma (HCC). Given that malignant PVT is a poor prognostic factor in patients with HCC, it is important to differentiate malignant PVT from benign PVT. Because malignant PVT has been reported to...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.1.116
更新日期:2013-01-01 00:00:00
abstract::Cholangiocarcinoma is a catastrophic tumor with a high mortality rate, for which surgery is the most reliable treatment. However, these tumors progress insidiously and are difficult to diagnose early. Most patients lack the opportunity to receive surgery due to the advanced disease stage at the time of the diagnosis, ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.103
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the usefulness of health screening for early detection and improved prognosis in pancreatic cancer. METHODS:Between 1995 and 2008, 176,361 examinees visited the Health Promotion Center (HPC). Twenty patients diagnosed with pancreatic cancer were enrolled. During th...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.194
更新日期:2011-06-01 00:00:00
abstract::Most patients who require biliary drainage can be treated by endoscopic retrograde cholangiopancreatography (ERCP)- guided procedures. However, ERCP can be challenging in patients with complications, such as malignant duodenal obstruction, or a surgically-altered anatomy, such as a Rouxen- Y anastomosis, which prevent...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl20096
更新日期:2020-07-23 00:00:00
abstract:BACKGROUND/AIMS:Benign bronchoesophageal fistula (BEF) is a rare condition that is usually treated surgically; however, less invasive endoscopy procedures have been attempted to overcome the disadvantages of surgery. The aim of this study was thus to determine the results of endoscopic management as a primary treatment...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.4.508
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND/AIMS:Although normal endoscopic findings are, as a rule, part of the diagnosis of microscopic colitis, sev-eral cases of macroscopic lesions (MLs) have been reported in collagenous colitis, but hardly in lymphocytic colitis (LC). The aim of this study was to investigate the endoscopic, clini-cal, and histopa...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13373
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.1.37
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2007.1.2.138
更新日期:2007-12-01 00:00:00
abstract:Background/Aims:Cholangiocytes are capable of reabsorbing bile salts from bile, but the pathophysiological significance of this process is unclear. To this end, we detected the expression and distribution of bile acid transport proteins in cholangiocytes from normal rat liver and analyzed the possible pathophysiologica...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18265
更新日期:2019-09-15 00:00:00
abstract:Background/Aims:Helicobacter pylori is a major risk factor for atrophic gastritis (AG) and gastric cancer. The correlation between H. pylori, AG and colorectal neoplasm (CRN) has only been examined in a limited number of studies, and findings have been inconclusive. We aimed to investigate the association between H. py...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15340
更新日期:2016-11-15 00:00:00
abstract:Background/Aims:The present study aimed to evaluate the safety and efficacy of simeprevir-based triple therapy with reduced doses of pegylated interferon (PEG-IFN) and ribavirin for interferon (IFN) ineligible patients, such as elderly and/or cirrhotic patients, and to elucidate the factors contributing to a sustained ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl16525
更新日期:2017-07-15 00:00:00
abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.31
更新日期:2010-03-01 00:00:00
abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16336
更新日期:2017-09-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. This cancer commonly arises against a background of chronic liver disease. As a result, a patient with HCC requires multidisciplinary care. Treatment options vary widely based on tumor burden and metastases. The most widely utili...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl15022
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.S1.S82
更新日期:2010-09-01 00:00:00
abstract:Background/Aims:Knowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program. Methods:In our screening program, asymptomatic subjects aged ≥...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17030
更新日期:2018-03-15 00:00:00
abstract::Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial distress syndrome (PDS; compris...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16055
更新日期:2017-05-15 00:00:00
abstract::Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease deve...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl15491
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND/AIMS:Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2014.8.3.318
更新日期:2014-05-01 00:00:00
abstract:Background/Aims:We recently identified recessive mutations in the solute carrier organic anion transporter family member 2A1 gene (SLCO2A1) as causative variants of chronic nonspecific multiple ulcers of the small intestine (chronic enteropathy associated with SLCO2A1, CEAS). The aim of this study was to investigate th...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18261
更新日期:2019-01-15 00:00:00
abstract::It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato-oncologic diseases who are undergoing inten...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.3.218
更新日期:2009-09-01 00:00:00
abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl19301
更新日期:2021-01-15 00:00:00
abstract::Biliary obstructions are rarely caused by a foreign body and have received sparse attention. We present an unusual case with pruritis and abdominal pain caused by impacted full length surgical gauze within the common bile duct. The patient had previously undergone an open cholecystectomy. Radiological investigations w...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.245
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/AIMS:Signal transducers and activators of transcription (STATs) are a family of transcription factors that are activated in response to cytokines and growth factors. STAT3 activation has been implicated in modulating the activity of downstream mediators, such as Bcl-xL and matrix metalloproteinase-2 (MMP-2)....
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.1.45
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The pathophysiologic mechanism of rectal hyposensitivity (RH) is not well documented, and the significance of RH in biofeedback therapy (BFT) has not been evaluated. Thus, we aimed to assess the effect of BFT in constipated patients according to the presence of RH. METHODS:Five hundred and ninety const...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.2.157
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl15167
更新日期:2015-11-23 00:00:00
abstract:Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular inv...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl16281
更新日期:2017-05-15 00:00:00