Abstract:
BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients with corticosteroid-refractory UC who received either infliximab or cyclosporine as a rescue therapy at a tertiary care hospital in Korea were reviewed. RESULTS:Among the 43 patients, 10 underwent rescue therapy with cyclosporine and the remaining 33 patients received infliximab. A follow-up of 12 months was completed for all patients. The colectomy rate at 12 months was 30% and 3% in the cyclosporine and the infliximab groups, respectively (p=0.034). However, the Cox proportional hazard model indicated that the treatment of rescue therapy was not an independent associate factor for preventing colectomy (p=0.164). In the subgroup analysis, infliximab with azathioprine was superior to cyclosporine for preventing colectomy (hazard ratio of infliximab with azathioprine compared with cyclosporine only, 0.073; 95% confidence interval, 0.008 to 0.629). CONCLUSIONS:No difference between infliximab and cyclosporine with respect to preventing colectomy was noted. However, infliximab with azathioprine may be more effective than cyclosporine alone for preventing colectomy.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Kim EH,Kim DH,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JHdoi
10.5009/gnl14120subject
Has Abstractpub_date
2015-09-23 00:00:00pages
601-6issue
5eissn
1976-2283issn
2005-1212pii
gnl14120journal_volume
9pub_type
杂志文章相关文献
Gut and Liver文献大全abstract:Background/Aims:Knowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program. Methods:In our screening program, asymptomatic subjects aged ≥...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17030
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.1.41
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND/AIMS:The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -neg...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.3.315
更新日期:2011-09-01 00:00:00
abstract::We report a case of malignant fibrous histiocytoma (MFH) of the right buttock with multiple metastases to the lung, bone, and small intestine. He received resection and end-to-end anastomosis of the jejunum for the jejunal metastatic tumor, and mass excision of the metastatic tumor of the left femur followed by closed...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2008.2.3.213
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND/AIMS:Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.5.532
更新日期:2013-09-01 00:00:00
abstract:Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18148
更新日期:2018-11-15 00:00:00
abstract::A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13358
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14018
更新日期:2015-01-01 00:00:00
abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18398
更新日期:2019-09-15 00:00:00
abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl15167
更新日期:2015-11-23 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.1.113
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The quality of bowel preparation (QBP) is the important factor in performing a successful colonoscopy. Several factors influencing QBP have been reported; however, some factors, such as the optimal preparation-to-colonoscopy time interval, remain controversial. This study aimed to determine the factors ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13228
更新日期:2014-11-01 00:00:00
abstract::Colonic diverticula are common whereas but rectal diverticula are very rare, with only sporadic reports in the literature since 1911. Most patients with rectal diverticula are diagnosed incidentally, inflammatory processes may have developed at the time of the diagnosis. We report the case of a 42-year-old woman prese...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.3.394
更新日期:2010-09-01 00:00:00
abstract::Cap polyposis is a rare disorder with characteristic endoscopic and histological features; its etiology is still unknown, and no specific treatment has been established. We report a case of cap polyposis that improved remarkably after infliximab infusion and had no recurrence for 3 years. ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.4.325
更新日期:2009-12-01 00:00:00
abstract::The combination of pegylated interferon (PEG-IFN) and ribavirin (RBV), the current therapy for hepatitis C virus (HCV) infection, has saved the lives of many HCV-infected patients. Direct-acting antivirals (DAAs) target several sites of HCV nonstructural proteins, resulting in the cessation of viral replication. The f...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl14083
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND/AIMS:Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study was to investigate the risk factors of post-ERCP bacteremia. METHODS:Among patients who underwen...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.2.228
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.3.363
更新日期:2013-05-01 00:00:00
abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17290
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND/AIMS:Several precut techniques have been used to gain biliary access for difficult cases. The aim of this study was to evaluate the success and complication rates of two precut techniques, transpancreatic septotomy (TPS) and needle knife infundibulotomy (NKI), in difficult biliary cannulation due to the pres...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14223
更新日期:2015-07-01 00:00:00
abstract::We report herein three cases of inflammatory myoglandular polyp (IMGP) presenting as hematochezia. The polyps had pedunculated, red, and smooth features, and were 12, 12, and 15 mm in diameter and located in the sigmoid colon, transverse colon, and rectum, respectively. Endoscopic polypectomies were performed. Histolo...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.146
更新日期:2010-03-01 00:00:00
abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...
journal_title:Gut and liver
pub_type: 杂志文章,meta分析
doi:10.5009/gnl18278
更新日期:2019-01-15 00:00:00
abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16336
更新日期:2017-09-15 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the effect of the synthetic S-allyl-L-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats. METHODS:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle con...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15584
更新日期:2016-09-15 00:00:00
abstract:Background/Aims:Data regarding the prognosis of early esophageal cancer are lacking. This study investigated the long-term outcomes and factors affecting the survival of patients with mucosal esophageal squamous cell carcinoma (T1aESCC). Methods:We analyzed the clinical and tumor-specific parameters of 263 patients wh...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl20254
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND/AIMS:Despite the potent suppression of the hepatitis B virus with modern antiviral agents, only a minority of HBeAg-positive patients achieve hepatitis B e antigen seroconversion. We aimed to explore the potential efficacy of combination therapy consisting of pegylated interferon (p-IFN) and an oral antivira...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14256
更新日期:2016-07-16 00:00:00
abstract:BACKGROUND/AIMS:Small core biopsy samples can occasionally be obtained with conventional endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Although most studies have focused on the cytological analysis of specimens, data regarding histological assessment is scarce. The aim of this study was to determi...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.5.605
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND/AIMS:We aimed to assess the effectiveness of self-expanding metal stent (SEMS) insertion by evaluating the learning curve in relation to the experience of an endoscopist. METHODS:We retrospectively analyzed the outcomes of 120 SEMS insertion procedures performed by one endoscopist in patients with malignant...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.3.328
更新日期:2012-07-01 00:00:00
abstract::A systematic review (SR) provides the best and most objective analysis of the existing evidence in a particular field. SRs and derived conclusions are essential for evidence-based strategies in medicine and evidence-based guidelines in clinical practice. The popularity of SRs has also increased markedly in the field o...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl14451
更新日期:2015-11-23 00:00:00
abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2007.1.2.138
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND/AIMS:The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune-mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune-mediated response or neuronal degeneratio...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.4.411
更新日期:2013-07-01 00:00:00