Cytapheresis in patients with severe ulcerative colitis after failure of intravenous corticosteroid: a long-term retrospective cohort study.

Abstract:

BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who had received CAP therapy for the first time within 1 year after UC diagnosis were followed for 36 months. One of the inclusion criteria was a clinical activity index (CAI) of >/=7 points at the end of a 2-week iv course of corticosteroid therapy. CAP therapy consisted of ten sessions over 10 weeks. RESULTS:CAP induced clinical remission (CAI/=12, n=25) than for moderately severe UC at entry (7

journal_name

Gut Liver

journal_title

Gut and liver

authors

Fukunaga K,Nagase K,Kusaka T,Hida N,Ohda Y,Yoshida K,Tozawa K,Kamikozuru K,Iimuro M,Nakamura S,Miwa H,Matsumoto T

doi

10.5009/gnl.2009.3.1.41

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

41-7

issue

1

eissn

1976-2283

issn

2005-1212

journal_volume

3

pub_type

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