Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan.


Background/Aims:The presence of invasion is a diagnostic criterion of early gastric cancer (EGC) in Korea, whereas diagnosis in Japan is based on enlarged nuclei and prominent nucleoli. Moreover, the depth of invasion is the location of cancer cell infiltration in Korea, whereas it is the location of lymphovascular invasion (LVI) or cancer cell infiltration in Japan. We evaluated the characteristics of EGC with LVI to uncover the effects of different diagnostic criteria. Methods:Consecutive T1-stage EGC patients who underwent complete resection were included after endoscopic or surgical resection. The presence of LVI was evaluated. Results:LVI was present in 112 of 1,089 T1-stage EGC patients. LVI was associated with depth of invasion (p<0.001) and age (p=0.017). The prevalence of LVI in mucosal cancer was significantly higher in Korea (p<0.001), whereas that of submucosal cancer was higher in Japan (p=0.024). For mucosal EGC types, LVI was positively correlated with diagnostic criteria applied in Korea (p=0.017). For submucosal EGC types, LVI was positively correlated with Japanese criteria (p=0.001) and old age (p=0.045). Conclusions:The higher prevalence of LVI for mucosal EGC in Korea and for submucosal EGC in Japan indicates that different diagnostic criteria should be considered when reading publications from other countries.


Gut Liver


Gut and liver


Lee SY,Yoshida N,Dohi O,Lee SP,Ichikawa D,Kim JH,Sung IK,Park HS,Otsuji E,Itoh Y,Shim CS,Han HS,Kishimoto M,Naito Y




Has Abstract


2017-05-15 00:00:00














  • Efficacy of Current Traction Techniques for Endoscopic Submucosal Dissection.

    abstract::This systematic review aimed to assess the efficacy of the current approach to tissue traction during the endoscopic submucosal dissection (ESD) of superficial esophageal cancer, early gastric cancer, and colorectal neoplasms. We performed a systematic electronic literature search of articles published in PubMed and s...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Abe S,Wu SYS,Ego M,Takamaru H,Sekiguchi M,Yamada M,Nonaka S,Sakamoto T,Suzuki H,Yoshinaga S,Matsuda T,Oda I,Saito Y

    更新日期:2020-11-15 00:00:00

  • Comparison of Indomethacin, Diclofenac and Aspirin-Induced Gastric Damage according to Age in Rats.

    abstract:BACKGROUND/AIMS:Aging gastric mucosa is known to have decreased mucosal defenses and increased susceptibility to injury by nonsteroidal anti-inflammatory drugs. Depending on the type of nonsteroidal anti-inflammatory drug (NSAID), the underlying mechanisms and the extent of damage to the stomach or intestine may differ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Seo PJ,Kim N,Kim JH,Lee BH,Nam RH,Lee HS,Park JH,Lee MK,Chang H,Jung HC,Song IS

    更新日期:2012-04-01 00:00:00

  • Autoamputation of a giant colonic lipoma.

    abstract::Most colonic lipomas are asymptomatic and need no treatment, whereas lesions larger than 2 cm can cause acute abdominal pain, changes in bowel habits, gastrointestinal bleeding, intussusception or bowel obstruction. Autoamputation of polypoid lesions in the gastrointestinal tract is indeed a rare phenomenon, and its p...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Jeong HK,Cho SB,Seo TJ,Lee KR,Lee WS,Kim HS,Joo YE

    更新日期:2011-09-01 00:00:00

  • Long-term outcome of photodynamic therapy with systemic chemotherapy compared to photodynamic therapy alone in patients with advanced hilar cholangiocarcinoma.

    abstract:BACKGROUND/AIMS:Patients with cholangiocarcinoma usually present at an advanced stage, and more than 50% of cases are not resectable at the time of diagnosis. Recently, photodynamic therapy (PDT) has been proposed as a palliative and neoadjuvant modality. We evaluated whether combination of PDT and chemotherapy is more...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Hong MJ,Cheon YK,Lee EJ,Lee TY,Shim CS

    更新日期:2014-05-01 00:00:00

  • Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center.

    abstract:Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Xu L,Li L,Wang P,Zhang M,Zhang Y,Hao X,Yan L,Li B,Wen T,Xu M

    更新日期:2019-11-15 00:00:00

  • Analysis of the effects of stent insertion and the factors related to stent retrieval in chronic pancreatitis accompanying main pancreatic duct obstruction.

    abstract:BACKGROUND/AIMS:Obstruction of the main pancreatic duct (MPD) has been considered one of the major causes for pain in chronic pancreatitis (CP). In this study, we evaluated the efficacy of MPD stenting in painful CP, and tried to determine a guideline for stent removal. METHODS:Sixteen patients with painful CP who und...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim CH,Bang S,Song KH,Park JY,Jeon TJ,Hong SP,Chung JB,Park SW,Song SY

    更新日期:2007-06-01 00:00:00

  • Potential Efficacy of Pegylated Interferon-α and a Nucleos(t)ide Analogue as Combination Therapy for HBeAg-Positive Chronic Hepatitis B.

    abstract:BACKGROUND/AIMS:Despite the potent suppression of the hepatitis B virus with modern antiviral agents, only a minority of HBeAg-positive patients achieve hepatitis B e antigen seroconversion. We aimed to explore the potential efficacy of combination therapy consisting of pegylated interferon (p-IFN) and an oral antivira...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Wi CI,Kim WR,Gross JB,Stadheim LM,Poterucha JJ

    更新日期:2016-07-16 00:00:00

  • Room for Quality Improvement in Endoscopist-Directed Sedation: Results from the First Nationwide Survey in Korea.

    abstract:BACKGROUND/AIMS:This study sought to characterize the current sedation practices of Korean endoscopists in real-world settings. METHODS:All active members of the Korean Society of Gastrointestinal Endoscopy were invited to complete an anonymous 35-item questionnaire. RESULTS:The overall response rate was 22.7% (1,332...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lee CK,Dong SH,Kim ES,Moon SH,Park HJ,Yang DH,Yoo YC,Lee TH,Lee SK,Hyun JJ,Korean Society of Gastrointestinal Endoscopy Task Force on Endoscopic Sedation.

    更新日期:2016-01-01 00:00:00

  • Cell Death and Liver Disease.

    abstract::Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications. Apoptosis is recognized relatively easily due to its unique morphology, b...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Aizawa S,Brar G,Tsukamoto H

    更新日期:2020-01-15 00:00:00

  • Clinical utility of plasma glypican-3 and osteopontin as biomarkers of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to eva...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lee HJ,Yeon JE,Suh SJ,Lee SJ,Yoon EL,Kang K,Yoo YJ,Kim JH,Seo YS,Yim HJ,Byun KS

    更新日期:2014-03-01 00:00:00

  • Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

    abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2015-01-01 00:00:00

  • Learning curves for colonoscopy: a prospective evaluation of gastroenterology fellows at a single center.

    abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Chung JI,Kim N,Um MS,Kang KP,Lee D,Na JC,Lee ES,Chung YM,Won JY,Lee KH,Nam TM,Lee JH,Choi HC,Lee SH,Park YS,Hwang JH,Kim JW,Jeong SH,Lee DH

    更新日期:2010-03-01 00:00:00

  • Predictive Value of Antiviral Effects in the Development of Hepatocellular Carcinoma in the General Korean Population with Chronic Hepatitis B.

    abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Shim JJ,Oh IH,Kim SB,Kim JW,Lee CK,Jang JY,Lee JS,Kim BH

    更新日期:2016-11-15 00:00:00

  • Liver transplantation.

    abstract::Liver transplantation has become a lifesaving procedure for patients who have chronic end-stage liver disease and acute liver failure. The satisfactory outcome of liver transplantation has led to insufficient supplies of deceased donor organs, particularly in East Asia. Hence, East Asian surgeons are concentrating on ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Moon DB,Lee SG

    更新日期:2009-09-01 00:00:00

  • Hepatic Steatosis Index in the Detection of Fatty Liver in Patients with Chronic Hepatitis B Receiving Antiviral Therapy.

    abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Chang JW,Lee HW,Kim BK,Park JY,Kim DY,Ahn SH,Han KH,Kim SU

    更新日期:2021-01-15 00:00:00

  • The Performance of Multiple Transgastric Procedures Using the Natural Orifice Transluminal Endoscopic Surgery Technique: Is Pure NOTES Satisfactory?

    abstract:BACKGROUND/AIMS:Although several groups have demonstrated the usefulness of natural orifice transluminal endoscopic surgery (NOTES), there is still concern about frequent serious adverse events. We performed this study to determine the technical feasibility and safety of pure NOTES with a transgastric approach in a por...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Song TJ,Seo DW,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2012-10-01 00:00:00

  • Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer.

    abstract:BACKGROUND/AIMS:The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS:The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Bae YS,Kim H,Noh SH,Kim H

    更新日期:2015-09-23 00:00:00

  • The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy.

    abstract:BACKGROUND/AIMS:Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation. METHODS:A total of 269 gastric hyperplastic polyps from 21...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Han AR,Sung CO,Kim KM,Park CK,Min BH,Lee JH,Kim JY,Chang DK,Kim YH,Rhee PL,Rhee JC,Kim JJ

    更新日期:2009-12-01 00:00:00

  • Visceral obesity as a risk factor for left-sided diverticulitis in Japan: a multicenter retrospective study.

    abstract:BACKGROUND/AIMS:Left-sided diverticulitis is increasing in Japan, and many studies report that left-sided diverticulitis is more likely to be severe. Therefore, it is important to identify the features and risk factors for left-sided diverticulitis. We hypothesized that left-sided diverticulitis in Japan is related to ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Yamada E,Ohkubo H,Higurashi T,Sakai E,Endo H,Takahashi H,Uchida E,Tanida E,Izumi N,Kanesaki A,Hata Y,Matsuura T,Fujisawa N,Komatsu K,Maeda S,Nakajima A

    更新日期:2013-09-01 00:00:00

  • Incidence of Cholangiocarcinoma with or without Previous Resection of Liver for Hepatolithiasis.

    abstract:BACKGROUND/AIMS:To investigate the incidence of cholangiocarcinoma in patients with hepatolithiasis with or without previous resection of liver. METHODS:From 2002 to 2009, we retrospectively reviewed 117 patients who were diagnosed and treated for hepatolithiasis in Korea University Guro Hospital. Among the 117 patien...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lee JY,Kim JS,Moon JM,Lim SA,Chung W,Lim EH,Lee BJ,Park JJ,Bak YT

    更新日期:2013-07-01 00:00:00

  • Factors Influencing the Diagnostic Accuracy of Acoustic Radiation Force Impulse Elastography in Patients with Chronic Hepatitis B.

    abstract:BACKGROUND/AIMS:To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). METHODS:Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from Novembe...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Park MS,Kim SW,Yoon KT,Kim SU,Park SY,Tak WY,Kweon YO,Cho M,Kim BK,Park JY,Kim DY,Ahn SH,Han KH

    更新日期:2016-03-01 00:00:00

  • A case of esophageal intramural pseudodiverticulosis.

    abstract::Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flask-shaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic findings include dilatation of excretory ducts of submucosal glands. The predominant symptom is dysphagia...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Chon YE,Hwang S,Jung KS,Lee HJ,Lee SG,Shin SK,Lee YC

    更新日期:2011-03-01 00:00:00

  • Benign bronchoesophageal fistula in adults: endoscopic closure as primary treatment.

    abstract:BACKGROUND/AIMS:Benign bronchoesophageal fistula (BEF) is a rare condition that is usually treated surgically; however, less invasive endoscopy procedures have been attempted to overcome the disadvantages of surgery. The aim of this study was thus to determine the results of endoscopic management as a primary treatment...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Ahn JY,Jung HY,Choi JY,Kim MY,Lee JH,Choi KS,Kim DH,Choi KD,Song HJ,Lee GH,Kim JH

    更新日期:2010-12-01 00:00:00

  • Histology combined with cytology by endoscopic ultrasound-guided fine needle aspiration for the diagnosis of solid pancreatic mass and intra-abdominal lymphadenopathy.

    abstract:BACKGROUND/AIMS:Small core biopsy samples can occasionally be obtained with conventional endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Although most studies have focused on the cytological analysis of specimens, data regarding histological assessment is scarce. The aim of this study was to determi...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim TH,Choi KH,Song HS,Kim JW,Jeon BJ

    更新日期:2013-09-01 00:00:00

  • Effect of Citric Acid on Accuracy of 13C-Urea Breath Test after Helicobacter pylori Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis.

    abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kwon YH,Kim N,Yoon H,Shin CM,Park YS,Lee DH

    更新日期:2019-09-15 00:00:00

  • Emerging therapies for hepatitis C.

    abstract::The combination of pegylated interferon (PEG-IFN) and ribavirin (RBV), the current therapy for hepatitis C virus (HCV) infection, has saved the lives of many HCV-infected patients. Direct-acting antivirals (DAAs) target several sites of HCV nonstructural proteins, resulting in the cessation of viral replication. The f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Kim DY,Ahn SH,Han KH

    更新日期:2014-09-01 00:00:00

  • Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression.

    abstract:BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45,...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim JH,Park JJ,Lee BJ,Joo MK,Chun HJ,Lee SW,Bak YT

    更新日期:2016-05-23 00:00:00

  • Anti-Saccharomyces cerevisiae Antibody in Pediatric Crohn's Disease Patients without Mucosal Healing Is a Useful Marker of Mucosal Damage.

    abstract:Background/Aims:We evaluated whether anti-Saccharomyces cerevisiae antibody (ASCA) titers are associated with diagnostic findings, disease activity, Paris classification phenotypes, and persistence after infliximab (IFX) treatment in children with Crohn's disease (CD). We also investigated the role of ASCA as a predict...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim MJ,Kim E,Kang B,Lee Y,Kang ES,Choe YH

    更新日期:2020-12-30 00:00:00

  • Noninvasive Assessment of Advanced Fibrosis Based on Hepatic Volume in Patients with Nonalcoholic Fatty Liver Disease.

    abstract:Background/Aims:Noninvasive liver fibrosis evaluation was performed in patients with nonalcoholic fatty liver disease (NAFLD). We used a quantitative method based on the hepatic volume acquired from gadoxetate disodium-enhanced (Gd-EOB-DTPA-enhanced) magnetic resonance imaging (MRI) for diagnosing advanced fibrosis in ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Hayashi T,Saitoh S,Fukuzawa K,Tsuji Y,Takahashi J,Kawamura Y,Akuta N,Kobayashi M,Ikeda K,Fujii T,Miyati T,Kumada H

    更新日期:2017-09-15 00:00:00

  • Inflammatory myoglandular polyps causing hematochezia.

    abstract::We report herein three cases of inflammatory myoglandular polyp (IMGP) presenting as hematochezia. The polyps had pedunculated, red, and smooth features, and were 12, 12, and 15 mm in diameter and located in the sigmoid colon, transverse colon, and rectum, respectively. Endoscopic polypectomies were performed. Histolo...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Chung SH,Son BK,Park YS,Jo YJ,Kim SH,Jun DW,Cheong ES,Lee WM,Ju JE

    更新日期:2010-03-01 00:00:00