Anti-Saccharomyces cerevisiae Antibody in Pediatric Crohn's Disease Patients without Mucosal Healing Is a Useful Marker of Mucosal Damage.


Background/Aims:We evaluated whether anti-Saccharomyces cerevisiae antibody (ASCA) titers are associated with diagnostic findings, disease activity, Paris classification phenotypes, and persistence after infliximab (IFX) treatment in children with Crohn's disease (CD). We also investigated the role of ASCA as a predictor of mucosal healing (MH) and clinical remission (CR). Methods:This study included 61 CD patients aged 19 years or younger who were diagnosed and treated between September 2010 and January 2019 and followed for at least 1 year. ASCA was regularly measured at the diagnosis of CD and at least 1 year after IFX therapy. Results:The average follow-up period was 3.8±3.4 years (range, 1.0 to 7.2 years). Regression analysis showed that the ASCA titer was the only factor associated with Simple Endoscopic Score for Crohn's Disease (SES-CD) or CR among all the parameters. In patients who had achieved MH (SES-CD=0), ASCA immunoglobulin G (IgG) was not associated with MH, but in patients without MH, ASCA IgG was associated with SES-CD (p=0.005) and CR (p<0.001). The cutoff value of ASCA IgG in patients with CR was 21.8 units. However, there was no difference in the relapse rate between the ASCA IgG-positive and -negative groups during the follow-up period. Conclusions:In patients who have not achieved MH, ASCA IgG is closely related to mucosal damage and CR. Unlike western studies, ASCA IgG may be more helpful in predicting prognosis than IgA in Korean patients, but it is not an appropriate indicator to predict the relapse of CD.


Gut Liver


Gut and liver


Kim MJ,Kim E,Kang B,Lee Y,Kang ES,Choe YH




Has Abstract


2020-12-30 00:00:00








  • Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.

    abstract:BACKGROUND/AIMS:To investigate the association between the baseline profiles and dynamics of hepatitis B virus (HBV) DNA polymerase gene mutations and the long-term virological response of lamivudine (LAM)-adefovir (ADV) combination therapy in patients with LAM-resistant chronic hepatitis B. METHODS:Seventy-five patie...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim J,Lee SH,Kim HS,Choi K,Jeong SW,Kim SG,Jang JY,Kim YS,Kim BS

    更新日期:2015-01-01 00:00:00

  • Inflammatory myoglandular polyps causing hematochezia.

    abstract::We report herein three cases of inflammatory myoglandular polyp (IMGP) presenting as hematochezia. The polyps had pedunculated, red, and smooth features, and were 12, 12, and 15 mm in diameter and located in the sigmoid colon, transverse colon, and rectum, respectively. Endoscopic polypectomies were performed. Histolo...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Chung SH,Son BK,Park YS,Jo YJ,Kim SH,Jun DW,Cheong ES,Lee WM,Ju JE

    更新日期:2010-03-01 00:00:00

  • Primary squamous cell carcinoma of the liver initially presenting with pseudoachalasia.

    abstract::Pseudoachalasia secondary to primary squamous cell carcinoma (SCC) of the liver is extremely rare and has not been reported until now. Here, we report a unique case of primary SCC of the liver initially presenting with progressive dysphagia along with short periods of significant weight loss. A 58-year-old man initial...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Choi MK,Kim GH,Song GA,Nam HS,Yi YS,Ahn KH,Kim S,Kim JY,Park DY

    更新日期:2012-04-01 00:00:00

  • A case of recurrent pancreatitis induced by trimethoprim-sulfamethoxazole re-exposure.

    abstract::A 32-year-old man presented with epigastric pain. He had a previous episode of acute pancreatitis of undetermined cause 2 years earlier. The patient had taken trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily because of acute urethritis 3 days prior to admission. No definite cause of acute pancreatitis co...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Park TY,Oh HC,Do JH

    更新日期:2010-06-01 00:00:00

  • Factors affecting tumor ablation during high intensity focused ultrasound treatment.

    abstract:BACKGROUND/AIMS:High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. METHODS:HIFU was ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Hassanuddin A,Choi JH,Seo DW,Ryu CH,Kim SH,Park DH,Lee SS,Lee SK,Kim MH

    更新日期:2014-07-01 00:00:00

  • Proteomic identification of proteins suggestive of immune-mediated response or neuronal degeneration in serum of achalasia patients.

    abstract:BACKGROUND/AIMS:The primary pathophysiologic abnormality in achalasia is known to be a loss of inhibitory myenteric ganglion cells, which may result from an immune-mediated response or neuronal degeneration. The aim of this study was to identify proteins suggestive of an immune-mediated response or neuronal degeneratio...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Im SK,Yeo M,Lee KJ

    更新日期:2013-07-01 00:00:00

  • Early Infliximab Yields Superior Long-Term Effects on Linear Growth in Pediatric Crohn's Disease Patients.

    abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Choi J,Kang B,Kim MJ,Sohn I,Lee HJ,Choe YH

    更新日期:2018-05-15 00:00:00

  • Cell Death and Liver Disease.

    abstract::Cell death is now reclassified into several types based on the mechanisms and morphologic phenotype. Understanding of such classifications offers insights into the pathogenesis of liver disease, as well as diagnostic or therapeutic implications. Apoptosis is recognized relatively easily due to its unique morphology, b...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Aizawa S,Brar G,Tsukamoto H

    更新日期:2020-01-15 00:00:00

  • Gastroparesis Updates on Pathogenesis and Management.

    abstract::Gastroparesis (Gp) is a chronic disease that presents with clinical symptoms of early satiety, bloating, nausea, vomiting, and abdominal pain. Along with these symptoms, an objective finding of delayed gastric emptying, along with a documented absence of gastric outlet obstruction, are required for diagnosis. This art...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Liu N,Abell T

    更新日期:2017-09-15 00:00:00

  • Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

    abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Hwangbo Y,Kim HJ,Park JS,Ryu KN,Kim NH,Shim J,Jang JY,Dong SH,Kim BH,Chang YW,Chang R

    更新日期:2010-09-01 00:00:00

  • Novel Prognostic Nomograms for Hepatocellular Carcinoma Patients with Microvascular Invasion: Experience from a Single Center.

    abstract:Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Xu L,Li L,Wang P,Zhang M,Zhang Y,Hao X,Yan L,Li B,Wen T,Xu M

    更新日期:2019-11-15 00:00:00

  • The learning curve for colorectal stent insertion for the treatment of malignant colorectal obstruction.

    abstract:BACKGROUND/AIMS:We aimed to assess the effectiveness of self-expanding metal stent (SEMS) insertion by evaluating the learning curve in relation to the experience of an endoscopist. METHODS:We retrospectively analyzed the outcomes of 120 SEMS insertion procedures performed by one endoscopist in patients with malignant...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lee JH,Yoon JY,Park SJ,Hong SP,Kim TI,Kim WH,Cheon JH

    更新日期:2012-07-01 00:00:00

  • A case of solitary rectal diverticulum presenting with a retrorectal mass.

    abstract::Colonic diverticula are common whereas but rectal diverticula are very rare, with only sporadic reports in the literature since 1911. Most patients with rectal diverticula are diagnosed incidentally, inflammatory processes may have developed at the time of the diagnosis. We report the case of a 42-year-old woman prese...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Jung SH,Kim JH

    更新日期:2010-09-01 00:00:00

  • Effect of biofeedback therapy in constipation according to rectal sensation.

    abstract:BACKGROUND/AIMS:The pathophysiologic mechanism of rectal hyposensitivity (RH) is not well documented, and the significance of RH in biofeedback therapy (BFT) has not been evaluated. Thus, we aimed to assess the effect of BFT in constipated patients according to the presence of RH. METHODS:Five hundred and ninety const...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Ahn JY,Myung SJ,Jung KW,Yang DH,Koo HS,Seo SY,Yoon IJ,Kim KJ,Ye BD,Byeon JS,Jung HY,Yang SK,Kim JH

    更新日期:2013-03-01 00:00:00

  • 2018 Korean Liver Cancer Association-National Cancer Center Korea Practice Guidelines for the Management of Hepatocellular Carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management...

    journal_title:Gut and liver

    pub_type: 杂志文章,实务指引


    authors: Korean Liver Cancer Association.,National Cancer Center.

    更新日期:2019-05-15 00:00:00

  • Proton pump inhibitor use before percutaneous endoscopic gastrostomy is associated with adverse outcomes.

    abstract:BACKGROUND/AIMS:Knowledge of the risk factors associated with adverse outcomes after percutaneous endoscopic gastrostomy (PEG) may be helpful for developing PEG recommendations. The purpose of this study was to identify the clinical risk factors associated with adverse clinical outcomes after PEG, especially regarding ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Im JP,Cha JM,Kim JW,Kim SE,Ryu DY,Kim EY,Kim ER,Chang DK

    更新日期:2014-05-01 00:00:00

  • Biologics for the Management of Inflammatory Bowel Disease: A Review in Tuberculosis-Endemic Countries.

    abstract::The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for surgery, and unprecedented outcomes including complete mucosal and histologic healing. However, an importan...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Banerjee R,Ali RAR,Wei SC,Adsul S

    更新日期:2020-11-15 00:00:00

  • Is Metabolic Syndrome One of the Risk Factors for Gallbladder Polyps Found by Ultrasonography during Health Screening?

    abstract:BACKGROUND/AIMS:We conducted this study to identify the risk factors for finding gallbladder polyps (GBP) in Korean subjects during health screening, and to determine the nature of the association between the presence of metabolic syndrome (MS) and the development of GBP METHODS: A total of 1,523 subjects were enrolled...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lim SH,Kim DH,Park MJ,Kim YS,Kim CH,Yim JY,Cho KR,Kim SS,Choi SH,Kim N,Cho SH,Oh BH

    更新日期:2007-12-01 00:00:00

  • Infliximab therapy impacts the peripheral immune system of immunomodulator and corticosteroid naïve patients with Crohn's disease.

    abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kato K,Fukunaga K,Kamikozuru K,Kashiwamura S,Hida N,Ohda Y,Takeda N,Yoshida K,Iimuro M,Yokoyama Y,Kikuyama R,Miwa H,Matsumoto T

    更新日期:2011-03-01 00:00:00

  • Emerging therapies for hepatitis C.

    abstract::The combination of pegylated interferon (PEG-IFN) and ribavirin (RBV), the current therapy for hepatitis C virus (HCV) infection, has saved the lives of many HCV-infected patients. Direct-acting antivirals (DAAs) target several sites of HCV nonstructural proteins, resulting in the cessation of viral replication. The f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Kim DY,Ahn SH,Han KH

    更新日期:2014-09-01 00:00:00

  • Depression Promotes the Onset of Irritable Bowel Syndrome through Unique Dysbiosis in Rats.

    abstract:Background/Aims:Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Takajo T,Tomita K,Tsuchihashi H,Enomoto S,Tanichi M,Toda H,Okada Y,Furuhashi H,Sugihara N,Wada A,Horiuchi K,Inaba K,Hanawa Y,Shibuya N,Shirakabe K,Higashiyama M,Kurihara C,Watanabe C,Komoto S,Nagao S,Kimura K,Mi

    更新日期:2019-05-15 00:00:00

  • One-Step Transpapillary Balloon Dilation under Cap-Fitted Endoscopy without a Preceding Sphincterotomy for the Removal of Bile Duct Stones in Billroth II Gastrectomy.

    abstract:BACKGROUND/AIMS:Endoscopic sphincterotomy may be limited in Billroth II gastrectomy because of difficulty in orientating the duodenoscope and sphincterotome as a result of altered anatomy. This study was planned to investigate the efficacy and safety of endoscopic transpapillary large balloon dilation (EPBD) without pr...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Lee TH,Hwang JC,Choi HJ,Moon JH,Cho YD,Yoo BM,Park SH,Kim JH,Kim SJ

    更新日期:2012-01-01 00:00:00

  • Endoscopic and Clinical Factors Affecting the Prognosis of Colorectal Endoscopic Submucosal Dissection-Related Perforation.

    abstract:BACKGROUND/AIMS:Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. METH...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kang DU,Choi Y,Lee HS,Lee HJ,Park SH,Yang DH,Yoon SM,Kim KJ,Ye BD,Myung SJ,Yang SK,Kim JH,Byeon JS

    更新日期:2016-05-23 00:00:00

  • Factors Influencing the Diagnostic Accuracy of Acoustic Radiation Force Impulse Elastography in Patients with Chronic Hepatitis B.

    abstract:BACKGROUND/AIMS:To determine factors predictive of discordance in staging liver fibrosis using liver biopsy (LB) and acoustic radiation force impulse (ARFI) elastography in patients with chronic hepatitis B (CHB). METHODS:Consecutive patients with CHB who underwent LB and ARFI elastography on the same day from Novembe...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Park MS,Kim SW,Yoon KT,Kim SU,Park SY,Tak WY,Kweon YO,Cho M,Kim BK,Park JY,Kim DY,Ahn SH,Han KH

    更新日期:2016-03-01 00:00:00

  • Current Definition of and Controversial Issues Regarding Postoperative Pancreatic Fistulas.

    abstract::The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of f...

    journal_title:Gut and liver

    pub_type: 杂志文章,评审


    authors: Marchegiani G,Andrianello S,Salvia R,Bassi C

    更新日期:2019-03-15 00:00:00

  • Prevalence of subjects at a high or very high risk of gastric cancer in Japan.

    abstract:BACKGROUND/AIMS:The presence of Helicobacter pylori (H. pylori) infection represents a high-risk state of gastric cancer, but the risk is even higher in gastric atrophy. H. pylori stool antigen (HpSA) and serum pepsinogen (PG) tests are useful tools for screening present infection and gastric atrophy, respectively. To ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Yamaoka M,Nakajima S

    更新日期:2009-06-01 00:00:00

  • Enteroscopy in Crohn's Disease: Are There Any Changes in Role or Outcomes Over Time? A KASID Multicenter Study.

    abstract:Background/Aims:Although balloon-assisted enteroscopy (BAE) enables endoscopic visualization of small bowel (SB) involvement in Crohn's disease (CD), there is no data on the changes in outcomes over time. We therefore investigated the changes in BAE use on CD patients over different time periods in terms of its role an...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Jeon SR,Kim JO,Byeon JS,Yang DH,Ko BM,Goong HJ,Jang HJ,Park SJ,Kim ER,Hong SN,Im JP,Kim SE,Koo JS,Eun CS,Chang DK,Korean Association for the Study of Intestinal Disease(KASID).

    更新日期:2020-07-06 00:00:00

  • Alcohol Consumption Can Reduce the Risk of Gallstone Disease: A Systematic Review with a Dose-Response Meta-Analysis of Case-Control and Cohort Studies.

    abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...

    journal_title:Gut and liver

    pub_type: 杂志文章,meta分析


    authors: Cha BH,Jang MJ,Lee SH

    更新日期:2019-01-15 00:00:00

  • Remission of cap polyposis maintained for more than three years after infliximab treatment.

    abstract::Cap polyposis is a rare disorder with characteristic endoscopic and histological features; its etiology is still unknown, and no specific treatment has been established. We report a case of cap polyposis that improved remarkably after infliximab infusion and had no recurrence for 3 years. ...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Kim ES,Jeen YT,Keum B,Seo YS,Chun HJ,Um SH,Kim CD,Ryu HS

    更新日期:2009-12-01 00:00:00

  • Knowledge Gaps among Physicians Caring for Multiethnic Populations at Increased Gastric Cancer Risk.

    abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...

    journal_title:Gut and liver

    pub_type: 杂志文章


    authors: Shah SC,Itzkowitz SH,Jandorf L

    更新日期:2018-01-15 00:00:00