Abstract:
:Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of clinical investigations and molecular pathological analyses of the roles of H. pylori eradication and aspirin administration in the prevention of MGC. In regard to the clinical studies, the results of meta-analyses and randomized control trials differ from those of retrospective studies: the former trials show that H. pylori eradication has a preventive effect on MGC, while the latter studies do not. This discrepancy may be at least partly attributable to differences in the follow-up periods: H. pylori eradication is more likely to prevent MGC over a long-term follow-up period (≥5 years) than over a short-term follow-up period. In addition, many studies have shown that aspirin may have an additive effect on MGC-risk reduction after H. pylori eradication has been achieved. Both H. pylori eradication and aspirin use induce molecular alterations in the atrophic gastritis mucosa but not in the intestinal metaplasia. Unfortunately, the molecular pathological analyses of these interventions have been limited by short follow-up periods. Therefore, a long-term prospective cohort is needed to clarify the changes in molecular events caused by these interventions.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Watari J,Tomita T,Tozawa K,Oshima T,Fukui H,Miwa Hdoi
10.5009/gnl19079subject
Has Abstractpub_date
2020-05-15 00:00:00pages
281-290issue
3eissn
1976-2283issn
2005-1212pii
gnl19079journal_volume
14pub_type
杂志文章,评审相关文献
Gut and Liver文献大全abstract::Serrated polyps are considered precursor lesions that account for 15% to 30% of colorectal cancers, and they are overrepresented as a cause of interval cancers. They are difficult to detect and resect comprehensively; however, recent data suggest that high definition endoscopy, chromoendoscopy (via spray catheter, pum...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19202
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND/AIMS:The quality of bowel preparation (QBP) is the important factor in performing a successful colonoscopy. Several factors influencing QBP have been reported; however, some factors, such as the optimal preparation-to-colonoscopy time interval, remain controversial. This study aimed to determine the factors ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13228
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND/AIMS:To evaluate the usefulness and safety of treating disseminated intravascular coagulation (DIC) complicating cholangitis primarily with antithrombin (AT) and thrombomodulin (rTM). METHODS:A DIC treatment algorithm was determined on the basis of plasma AT III levels at the time of DIC diagnosis and DIC s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.3.363
更新日期:2013-05-01 00:00:00
abstract:Background/Aims:The hepatic steatosis index (HSI) is a noninvasive method to assess the severity of hepatic steatosis. Antiviral therapy (AVT) can impact aspartate aminotransferase and alanine aminotransferase levels, which are the main components of the HSI. Thus, we investigated the accuracy of the HSI in detecting h...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl19301
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the usefulness of health screening for early detection and improved prognosis in pancreatic cancer. METHODS:Between 1995 and 2008, 176,361 examinees visited the Health Promotion Center (HPC). Twenty patients diagnosed with pancreatic cancer were enrolled. During th...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.194
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/AIMS:Although several groups have demonstrated the usefulness of natural orifice transluminal endoscopic surgery (NOTES), there is still concern about frequent serious adverse events. We performed this study to determine the technical feasibility and safety of pure NOTES with a transgastric approach in a por...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.4.457
更新日期:2012-10-01 00:00:00
abstract::It is known that neutropenia caused by combination pegylated interferon plus ribavirin therapy for hepatitis C virus (HCV) infection is well tolerated and carries a negligible risk of infection. Neutropenic enterocolitis is encountered most frequently in patients with hemato-oncologic diseases who are undergoing inten...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.3.218
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND/AIMS:Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects. M...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.4.432
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND/AIMS:Although laparoscopic fundoplication is a well-established therapy for gastroesophageal reflux disease (GERD) in Western countries, the mainstay of GERD treatment in Korea is long-term proton pump inhibitor (PPI) use. The aim of the present study was to evaluate nationwide data regarding antireflux surg...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15406
更新日期:2016-09-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second most common cause of cancer death worldwide. This cancer commonly arises against a background of chronic liver disease. As a result, a patient with HCC requires multidisciplinary care. Treatment options vary widely based on tumor burden and metastases. The most widely utili...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl15022
更新日期:2015-07-01 00:00:00
abstract:Background/Aims:Obesity is a risk factor for gastroesophageal reflux disease (GERD), with several studies demonstrating positive associations between body mass index (BMI) and GERD symptoms. However, little is known about the effect of BMI changes on erosive esophagitis (EE). In this study, we investigated whether BMI ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18148
更新日期:2018-11-15 00:00:00
abstract::Portal vein thrombosis (PVT) is commonly associated with liver cirrhosis, irrespective of the presence of hepatocellular carcinoma (HCC). Given that malignant PVT is a poor prognostic factor in patients with HCC, it is important to differentiate malignant PVT from benign PVT. Because malignant PVT has been reported to...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.1.116
更新日期:2013-01-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and the fourth most common cancer in men in Korea, where the prevalence of chronic hepatitis B infection is high in middle-aged and elderly patients. These practice guidelines will provide useful and constructive advice for the clinical management...
journal_title:Gut and liver
pub_type: 杂志文章,实务指引
doi:10.5009/gnl19024
更新日期:2019-05-15 00:00:00
abstract:Background/Aims:Although studies using conventional animal models have shown that specific stressors cause irritable bowel syndrome (IBS), it is unclear whether depression itself causes IBS. Our aim was to establish a rat model to determine if depression itself promotes the onset of IBS and to elucidate the role of gut...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18296
更新日期:2019-05-15 00:00:00
abstract::The management of Helicobacter pylori infection in Singapore remains a clinical challenge. Similar to other regions, there has been an increase in antibiotic resistance rates through the years. Nonetheless, over the past two decades, clarithromycin-based triple therapy has continued to be used as the first line treatm...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19308
更新日期:2021-01-15 00:00:00
abstract:Background/Aims:The benefit of oral antiviral therapy in preventing hepatocellular carcinoma (HCC) in the general population is not well understood. We used a novel prediction method to estimate the risk of HCC in the Korean population based on various treatment guidelines. Methods:The 5-year risk of HCC following ant...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15426
更新日期:2016-11-15 00:00:00
abstract::The goal of antiviral therapy for patients with chronic hepatitis C virus (HCV) infection is to attain a sustained virologic response (SVR), which is defined as undetectable serum HCV-RNA levels at 6 months after the cessation of treatment. Major improvements in antiviral therapy for chronic hepatitis C have occurred ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.117
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND/AIMS:The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. METHODS:The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15133
更新日期:2015-09-23 00:00:00
abstract:Background/Aims:Electrohydraulic lithotripsy (EHL) under endoscopic retrograde cholangiopancreatography (ERCP) guidance can be an option to treat difficult stones. Recently, a digital, single-operator cholangioscope (SPY-DS) has become available. Peroral transluminal cholangioscopy (PTLC) using SPY-DS has also been rep...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17352
更新日期:2018-07-15 00:00:00
abstract:BACKGROUND/AIMS:The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -neg...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.3.315
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45,...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15208
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND/AIMS:As the incidence rate of and mortality from pseudomembranous colitis (PMC) are increasing worldwide, it is important to study the simple predictive risk factors for PMC among patients with hospital-acquired diarrhea (HAD). This study focused on identifying the clinical risk factors that can easily predi...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2014.8.1.41
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.2.186
更新日期:2010-06-01 00:00:00
abstract::Cholangiocarcinoma is a catastrophic tumor with a high mortality rate, for which surgery is the most reliable treatment. However, these tumors progress insidiously and are difficult to diagnose early. Most patients lack the opportunity to receive surgery due to the advanced disease stage at the time of the diagnosis, ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.103
更新日期:2010-03-01 00:00:00
abstract:Background/Aims:Although balloon-assisted enteroscopy (BAE) enables endoscopic visualization of small bowel (SB) involvement in Crohn's disease (CD), there is no data on the changes in outcomes over time. We therefore investigated the changes in BAE use on CD patients over different time periods in terms of its role an...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl20023
更新日期:2020-07-06 00:00:00
abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.1.37
更新日期:2011-03-01 00:00:00
abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18398
更新日期:2019-09-15 00:00:00
abstract:Background/Aims:Microvascular invasion (MVI) is an established risk factor for hepatocellular carcinoma (HCC). However, prediction models that specifically focus on the individual prognoses of HCC patients with MVI is lacking. Methods:A total of 385 HCC patients with MVI were randomly assigned to training and validati...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18489
更新日期:2019-11-15 00:00:00
abstract::A 32-year-old man presented with epigastric pain. He had a previous episode of acute pancreatitis of undetermined cause 2 years earlier. The patient had taken trimethoprim (80 mg) and sulfamethoxazole (400 mg) twice daily because of acute urethritis 3 days prior to admission. No definite cause of acute pancreatitis co...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.2.250
更新日期:2010-06-01 00:00:00
abstract::A 75-year-old Japanese man with chronic hepatitis C was found to have a large liver tumor and multiple nodules in the bilateral lungs. We diagnosed the tumor as hepatocellular carcinoma (HCC) with multiple lung metastases based on imaging studies and high titers of HCC tumor markers. Remarkably, without any anticancer...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13358
更新日期:2014-09-01 00:00:00