Abstract:
:The advent of biologics and biologic therapy has transformed the management of inflammatory bowel disease (IBD) with enhanced early and adequate responses to treatment, fewer hospitalizations, a reduced need for surgery, and unprecedented outcomes including complete mucosal and histologic healing. However, an important issue with the use of anti-tumor necrosis factor (anti-TNF) agents in IBD is the increased risk of tuberculosis (TB). This is compounded by the diagnostic dilemma when differentiating between Crohn's disease and gastrointestinal TB, and the potentially serious consequences of initiating an incorrect treatment in the case of misdiagnosis. The interplay between IBD and TB is most relevant in Asia, where more than 60% of the 10.4 million new TB cases in 2016 were reported. A number of studies have reported an increased risk of TB with anti-TNF agents, including in patients who had tested negative for TB prior to treatment initiation. The limited evidence currently available regarding adhesion molecule antagonists such as vedolizumab suggests a comparatively lower risk of TB, thus making them a promising option for IBD management in TBendemic regions. This comprehensive review examines the available literature on the risk of TB with the use of biologics in the TB-endemic regions of Asia, focusing on the diagnostic dilemma, the risk of reactivation, and the optimized management algorithms for latent and active disease.
journal_name
Gut Liverjournal_title
Gut and liverauthors
Banerjee R,Ali RAR,Wei SC,Adsul Sdoi
10.5009/gnl19209subject
Has Abstractpub_date
2020-11-15 00:00:00pages
685-698issue
6eissn
1976-2283issn
2005-1212pii
gnl19209journal_volume
14pub_type
杂志文章,评审相关文献
Gut and Liver文献大全abstract:BACKGROUND/AIMS:In patients with corticosteroid-refractory ulcerative colitis (UC), cyclosporine or infliximab may be added to the treatment regimen to induce remission. Here, we aimed to compare the efficacy of cyclosporine and infliximab. METHODS:Between January 1995 and May 2012, the medical records of 43 patients ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl14120
更新日期:2015-09-23 00:00:00
abstract::Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions i...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl16033
更新日期:2016-09-15 00:00:00
abstract:BACKGROUND/AIMS:The role of Helicobacter pylori in gastric carcinogenesis is unclear, but H. pylori infection is thought to predispose carriers to gastric cancer. The aim of this study was to investigate the relationship between the extent of DNA damage in normal gastric epithelial cells and H. pylori-positive and -neg...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.3.315
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND/AIMS:As the incidence rate of and mortality from pseudomembranous colitis (PMC) are increasing worldwide, it is important to study the simple predictive risk factors for PMC among patients with hospital-acquired diarrhea (HAD). This study focused on identifying the clinical risk factors that can easily predi...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2014.8.1.41
更新日期:2014-01-01 00:00:00
abstract:Background/Aims:Gallstone disease (GSD) is a common gastrointestinal disorder. Clinical epidemiological studies revealed that alcohol consumption has a preventive effect on the development of GSD. This study aimed to evaluate the relative risks of drinking for GSD development and investigate the dose-response relations...
journal_title:Gut and liver
pub_type: 杂志文章,meta分析
doi:10.5009/gnl18278
更新日期:2019-01-15 00:00:00
abstract:Background/Aims:Although gastric cancer (GC) prevalence in the United States overall is low, there is significantly elevated risk in certain racial/ethnic groups. Providers caring for high-risk populations may not be fully aware of GC risk factors and may underestimate the potential for selective screening. Our aim was...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17091
更新日期:2018-01-15 00:00:00
abstract:Background/Aims:Information regarding the efficacy of early infliximab treatment in pediatric patients with Crohn's disease (CD) is limited. We aimed to evaluate the impact of early combined immunosuppression on linear growth in pediatric patients with CD by performing step-up comparisons. Methods:This retrospective s...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl17290
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND/AIMS:Sacroiliitis (SI) is one of the most frequent extraintestinal manifestations in inflammatory bowel disease (IBD) patients, but the exact prevalence has not been evaluated in Asia. There are few data on the association between SI and other clinical features of IBD. The prevalence of SI was evaluated usin...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.3.338
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND/AIMS:The aim of this study was to evaluate the usefulness of health screening for early detection and improved prognosis in pancreatic cancer. METHODS:Between 1995 and 2008, 176,361 examinees visited the Health Promotion Center (HPC). Twenty patients diagnosed with pancreatic cancer were enrolled. During th...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.2.194
更新日期:2011-06-01 00:00:00
abstract::The International Study Group for Pancreatic Fistula (ISGPF) made the first attempt to standardize the outcome measure of fistulas in the field of pancreatic surgery by publishing the definition and classification of postoperative pancreatic fistulas (POPFs) in 2005. POPFs were determined by any measurable volume of f...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl18229
更新日期:2019-03-15 00:00:00
abstract::Background/Aims: Although acid suppressants are widely used for the prevention or treatment of drug-induced upper gastrointestinal bleeding (GIB), evidence regarding the prevention of anticoagulant-related GIB is scarce. The aim of this study was to evaluate the protective effect of acid suppressants against an...
journal_title:Gut and liver
pub_type: 杂志文章,meta分析
doi:10.5009/gnl19009
更新日期:2020-01-15 00:00:00
abstract::Esophageal intramural pseudodiverticulosis (EIP) is a rare benign disease that is characterized by multiple tiny flask-shaped outpouching lesions of the esophageal wall. The etiology is unknown, but the pathologic findings include dilatation of excretory ducts of submucosal glands. The predominant symptom is dysphagia...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.1.93
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND/AIMS:Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study involved patients with severe UC who refracted to intravenous (iv) corticosteroid. METHODS:Forty-seven UC patients who...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2009.3.1.41
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND/AIMS:M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS:Healthy volunteers a...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl13457
更新日期:2015-09-23 00:00:00
abstract:BACKGROUND/AIMS:Infliximab (IFX), an antibody to tumor necrosis factor, (TNF)-α has efficacy in treating Crohn's disease (CD). However, knowledge of the potential effects of IFX on patients' immune profiles is lacking. The purpose of this study was to reveal the immunological effects of IFX. METHODS:Twenty-two patient...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.1.37
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND/AIMS:α-Fetoprotein (AFP) is the biomarker most widely used to detect hepatocellular carcinoma (HCC), despite its suboptimal diagnostic accuracy. Glypican-3 (GPC3) and osteopontin (OPN) are secreted glycoproteins that are reportedly associated with tumorigenesis and metastasis. This study was conducted to eva...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2014.8.2.177
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIMS:Bacteremia following endoscopic retrograde cholangiopancreatography (ERCP) is a severe complication, but the risk factors for this condition have not yet been clearly determined. Thus, the aim of this study was to investigate the risk factors of post-ERCP bacteremia. METHODS:Among patients who underwen...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.2.228
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND/AIMS:Although colorectal endoscopic submucosal dissection (ESD)-related perforation is not uncommon, the factors affecting clinical outcomes after perforation have not been investigated. This study was designed to investigate the factors influencing the clinical course of ESD-related colon perforation. METH...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15252
更新日期:2016-05-23 00:00:00
abstract:Background/Aims:The validity of 13C-urea breath test (13C-UBT) for Helicobacter pylori detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of 13C-Urea breath test after H. pylori eradication therapy in a region where atrophic gastritis is common...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl18398
更新日期:2019-09-15 00:00:00
abstract::Serrated polyps are considered precursor lesions that account for 15% to 30% of colorectal cancers, and they are overrepresented as a cause of interval cancers. They are difficult to detect and resect comprehensively; however, recent data suggest that high definition endoscopy, chromoendoscopy (via spray catheter, pum...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl19202
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND/AIMS:Ischemic colitis includes a wide clinical spectrum ranging from mild to severe forms. This study aimed to determine the factors that are related to the occurrence of severe ischemic colitis. METHODS:This multicenter study was conducted retrospectively in Korea. The patients were divided into mild and s...
journal_title:Gut and liver
pub_type: 杂志文章,多中心研究
doi:10.5009/gnl15167
更新日期:2015-11-23 00:00:00
abstract:BACKGROUND/AIMS:Recent data from Western populations have suggested that patients with sporadic duodenal adenomas are at a higher risk for the development of colorectal neoplasia. In this study, we compared the frequency of colorectal neoplasia in patients with sporadic duodenal adenomas to healthy control subjects. M...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2011.5.4.432
更新日期:2011-12-01 00:00:00
abstract::Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease deve...
journal_title:Gut and liver
pub_type: 杂志文章,评审
doi:10.5009/gnl15491
更新日期:2016-07-15 00:00:00
abstract:BACKGROUND/AIMS:Although normal endoscopic findings are, as a rule, part of the diagnosis of microscopic colitis, sev-eral cases of macroscopic lesions (MLs) have been reported in collagenous colitis, but hardly in lymphocytic colitis (LC). The aim of this study was to investigate the endoscopic, clini-cal, and histopa...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl13373
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND/AIMS:Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. METHODS:The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45,...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl15208
更新日期:2016-05-23 00:00:00
abstract:BACKGROUND/AIMS:Small core biopsy samples can occasionally be obtained with conventional endoscopic ultrasonography-guided fine needle aspiration (EUS-FNA). Although most studies have focused on the cytological analysis of specimens, data regarding histological assessment is scarce. The aim of this study was to determi...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2013.7.5.605
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND/AIMS:Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. METHODS:A t...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.1.31
更新日期:2010-03-01 00:00:00
abstract::Enteropathy-type T-cell lymphoma (ETL) or enteropathy-associated T-cell lymphoma is a very rare malignant intestinal tumor. ETL is usually diagnosed by surgery. Endoscopic findings of ETL are not well known, and there are few reports of findings from endoscopy that has been performed only using white light. Additional...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2012.6.4.516
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND/AIMS:To prospectively evaluate our palliative management of unresectable cholangiocarcinoma (CC) treated with tailored multimodal oncological therapy. METHODS:Between January 2005 and January 2010, 50 consecutive patients with unresectable CC and jaundice were palliated with percutaneous drainage. Forty-thr...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2010.4.S1.S82
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND/AIMS:High intensity focused ultrasound (HIFU) utilizes a targeted extracorporeal focused ultrasound beam to ablate neoplastic pancreatic tissue. We used an in vitro model to examine the effects of bone, metallic stents, plastic stents, metal plates, and cyst-like lesions on HIFU treatment. METHODS:HIFU was ...
journal_title:Gut and liver
pub_type: 杂志文章
doi:10.5009/gnl.2014.8.4.433
更新日期:2014-07-01 00:00:00