Abstract:
:Oligodendrocyte precursor cell (OPC) maturation requires membrane addition for myelin sheath formation. Since the Rab system has been shown to contribute to membrane addition in other cell types, in this study, we explored the role of Rab in OPC maturation. SiRNA and shRNA techniques and conditional knockout mice provided in vitro and in vivo evidence that Rab10 is involved in OPC maturation and may affect myelination during OPC development.
journal_name
Cell Mol Neurobioljournal_title
Cellular and molecular neurobiologyauthors
Zhang ZH,Zhao WQ,Ma FF,Zhang H,Xu XHdoi
10.1007/s10571-017-0465-5subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1303-1310issue
7eissn
0272-4340issn
1573-6830pii
10.1007/s10571-017-0465-5journal_volume
37pub_type
杂志文章abstract::Depression is a major psychiatric disorder affecting nearly 21% of the world population and imposes a substantial health burden on society. Although significant progress has been made in depression research, the common molecular mechanism of antidepressants is still far from clearly understood. The neuroprotective eff...
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