Abstract:
:Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1rKO mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1rKO mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1rKO HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1rKO . MED1 transcription was impaired in the epidermis of K15-Igf1rKO mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation.
journal_name
Exp Dermatoljournal_title
Experimental dermatologyauthors
Castela M,Linay F,Roy E,Moguelet P,Xu J,Holzenberger M,Khosrotehrani K,Aractingi Sdoi
10.1111/exd.13287subject
Has Abstractpub_date
2017-09-01 00:00:00pages
785-791issue
9eissn
0906-6705issn
1600-0625journal_volume
26pub_type
杂志文章abstract::CD44 and l-selectin (CD62L) are major adhesion receptors that mediate leucocyte recruitment at inflammatory sites and lymph nodes, by supporting cell rolling under blood flow. Both CD44 and CD62L have been implicated in inflammatory skin disorders, but their specific involvement in an immediate-type allergic reaction ...
journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
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doi:10.1034/j.1600-0625.2000.009002152.x
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journal_title:Experimental dermatology
pub_type: 信件
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.1995.tb00208.x
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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journal_title:Experimental dermatology
pub_type: 杂志文章
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.1995.tb00227.x
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1600-0625.1996.tb00121.x
更新日期:1996-08-01 00:00:00
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journal_title:Experimental dermatology
pub_type: 杂志文章
doi:10.1111/exd.12422
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journal_title:Experimental dermatology
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pub_type: 信件
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journal_title:Experimental dermatology
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journal_title:Experimental dermatology
pub_type: 杂志文章,评审
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