Abstract：
:Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by oxygenated sesquiterpenes containing a furan ring. In the present work we explored the potential of its essential oils obtained from different organs and the main oxygenated sesquiterpenes, namely isofuranodiene, germacrone and β-acetoxyfuranoeudesm-4(15)-ene, as inhibitors of Trypanosoma brucei. All essential oils effectively inhibited the growth of parasite showing IC50 values of 1.9-4.0μg/ml. Among the main essential oil constituents, isofuranodiene exhibited a significant and selective inhibitory activity against T. brucei (IC50 of 0.6μg/ml, SI=30), with β-acetoxyfuranoeudesm-4(15)-ene giving a moderate potentiating effect. These results shed light on the possible application of isofuranodiene as an antiprotozoal agent to be included in combination treatments aimed not only at curing patients but also at preventing the diffusion of HAT.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Petrelli R,Ranjbarian F,Dall'Acqua S,Papa F,Iannarelli R,Ngahang Kamte SL,Vittori S,Benelli G,Maggi F,Hofer A,Cappellacci Ldoi
10.1016/j.parint.2017.01.001subject
Has Abstractpub_date
2017-04-01 00:00:00pages
146-151issue
2eissn
1383-5769issn
1873-0329pii
S1383-5769(16)30423-8journal_volume
66pub_type
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