Abstract：
:Host-parasite interaction during infection with the liver fluke Opisthorchis viverrini plays an important role in opisthorchiasis-associated cholangiocarcinoma via nitric oxide (NO) production. Host cells induce nitric oxide synthase (NOS)-dependent DNA damage and secrete Ras-related C3 botulinum toxin substrate (Rac)1, heme oxygenase (HO)-1, and gelatinases (matrix metalloproteinase (MMP)2 and MMP9). We evaluated whether these enzymes are expressed in O. viverrini. Colocalization of NOS and Rac1 was most prominently detected on day 30 post-infection (p.i.) in the gut, reproductive organ, eggs, acetabular and tegument. Expression of HO-1, an antioxidative enzyme, increased in a similar pattern to NOS, but was not present in the tegument. The levels of nitrate/nitrite, end products of NO, and ferric reducing antioxidant capacity, an indicator of antioxidant enzyme capacity, in parasite homogenates were highest on day 30 p.i. and then decreased on day 90 p.i. In contrast, zymography revealed that MMP2 and MMP9 were not present in parasite homogenates at all time points. In conclusion, O. viverrini induces NOS expression and NO production, but does not express gelatinases. The study may provide basic information and an insight into drug design for prevention and/or intervention approaches against O. viverrini infection.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Prakobwong S,Pinlaor P,Charoensuk L,Khoontawad J,Yongvanit P,Hiraku Y,Pinlaor Sdoi
10.1016/j.parint.2011.06.017subject
Has Abstractpub_date
2012-03-01 00:00:00pages
112-7issue
1eissn
1383-5769issn
1873-0329pii
S1383-5769(11)00087-0journal_volume
61pub_type
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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更新日期：2011-01-01 00:00:00
