Abstract：
:Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the pericarp and fruit of Garcinia mangostana and of the synthetic derivative mangostin diacetate. Mangostin and mangostin diacetate lacked activity against the nematodes Heligmosomoides polygyrus (third-stage larvae (L3)), Ancylostoma ceylanicum L3, and Trichuris muris adults and showed only low activity against A. ceylanicum adults (IC₅₀s of 91 μg/ml) in vitro. Mangostin showed promising activities (IC₅₀ of 2.9-15.6 μg/ml) against the trematodes Schistosoma mansoni, Echinostoma caproni, and Fasciola hepatica in vitro. Single oral doses (400 mg/kg and 800 mg/kg) of the drugs achieved worm burden reductions ranging from 0 to 38% and 11-54% against S. mansoni and E. caproni in vivo, respectively. Pharmacokinetic studies would be helpful to understand the differences observed between in vitro and in vivo activities and lacking dose-response relationships.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Keiser J,Vargas M,Winter Rdoi
10.1016/j.parint.2012.01.004subject
Has Abstractpub_date
2012-06-01 00:00:00pages
369-71issue
2eissn
1383-5769issn
1873-0329pii
S1383-5769(12)00005-0journal_volume
61pub_type
杂志文章abstract：:Schistosomiasis is one of the most prevalent and serious parasitic diseases in the world and remains an important public health problem in China. Screening and discovery of an effective vaccine candidate or new drug target is crucial for the control of this disease. In this study, we cloned a cDNA encoding Schistosoma...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.03.005
更新日期：2012-09-01 00:00:00
abstract：:Cardicola ambrosioi n. sp. (Digenea: Sanguinicolidae) is found in the blood vessels of liver and gills of the Brazilian flathead, Percophis brasiliensis Quoy and Gaimard, 1824 (Pisces: Percophidae), from Mar del Plata, Argentina. Among the 13 known species within Cardicola Short, 1953, the new species closely resemble...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.03.002
更新日期：2006-09-01 00:00:00
abstract：:Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.09.011
更新日期：2015-06-01 00:00:00
abstract：:The stomach bot fly species in Asian elephants has long been known as Cobboldia elephantis. However, there is no genetic information available for this species to date. Here, we report that a third-instar fly larva was excreted from a captive Asian elephant four months after export from an elephant camp in Myanmar to ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.102035
更新日期：2020-04-01 00:00:00
abstract：:Except for imported cases, we have had no new Schistosoma japonicum infection in Japan since 1977. But there are still two habitats of the intermediate snail host: Oncomelania nosophora in the previous endemic areas of Kofu Basin and Obitsu. O. nosophora from Kofu Basin and Obitsu are susceptible to Chinese and Philip...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/s1383-5769(03)00058-8
更新日期：2003-12-01 00:00:00
abstract：:The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.004
更新日期：2015-04-01 00:00:00
abstract：:It has been reported that three human Taenia species are distributed in Indonesia: Taenia solium, Taenia asiatica and Taenia saginata. T. asiatica is well known in North Sumatra, especially on Samosir island in Lake Toba. T. solium and T. saginata are known from Bali. T. solium is most serious public health issue in P...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.024
更新日期：2006-01-01 00:00:00
abstract：:A schistosome genome project was initiated by the World Health Organization in 1994 with the notion that the best prospects for identifying new targets for drugs, vaccines, and diagnostic development lie in schistosome gene discovery, development of chromosome maps, whole genome sequencing and genome analysis. Schisto...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2004.01.009
更新日期：2004-06-01 00:00:00
abstract：:We describe the cloning of a full length calpain-encoding cDNA constructed from two truncated cDNAs isolated from a cDNA library prepared with mRNA isolated from adult worms of the Philippine strain of Schistosoma japonicum. The cDNA sequence is 2.456 kb in length and predicts a protein of 758 residues with a molecula...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(99)00021-5
更新日期：2000-01-01 00:00:00
abstract：:Dioctophymosis is the disease caused by the nematode Dioctophyme renale, normally found parasitizing the right kidney of dogs. The absence of symptoms is frequent in parasitized animals. The surgical procedures are commonly performed to treat this disease. This work describes a case involving a canine with renal and e...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102211
更新日期：2021-02-01 00:00:00
abstract：:The antimalarial activity of the hot-water extract of Hydrangea macrophylla var. Otaksa leaves was evaluated against Plasmodium yoelii 17XL in mice. Non-treated control mice died from 6 to 7 days after infection, but mice treated with the leaf extract survived during the experiment. Mice given the extract orally showe...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00069-6
更新日期：2001-03-01 00:00:00
abstract：:The largest subunit of eukaryotic RNA polymerase II (RNA Pol II) of several members of Kinetoplastida order and other early diverging eukaryote contains a serine, tyrosine and proline-rich domain in the carboxyl-terminal instead of the typical heptapeptides repeats found in most eukaryotes. The lack of these repeats s...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(03)00009-6
更新日期：2003-09-01 00:00:00
abstract：:The outcome of Plasmodium yoelii 17XL (P.y17XL)-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, depends largely on the establishment of effective Th1 and Th2 responses and a successful switch between Th1 and Th2 responses, as well as appropriate functioning of CD4(+)CD25(+)Foxp3(+)regulatory T ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.05.005
更新日期：2010-09-01 00:00:00
abstract：:Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of parasitized red blood cells (PRBCs) mediate adhesion of PRBCs to host vascular endothelial receptors and is considered responsible for pathogenesis of severe P. falciparum malaria. The present study was undertaken to measure cell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.11.003
更新日期：2007-03-01 00:00:00
abstract：:In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a closely related Apicompl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.08.006
更新日期：2015-02-01 00:00:00
abstract：:Alveolar echinococcosis (AE) of the liver caused by the metacestode of the fox tapeworm Echinococcus multilocularis is characterized by a multivesicular structure surrounded by an extensive fibro-inflammatory host reaction. The lesions behave like a slow-growing liver cancer, without sharp limits between the parasitic...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.053
更新日期：2006-01-01 00:00:00
abstract：:Chromosome analyses were performed on three races (alpha, beta, gamma) of Neotricula aperta which were previously reported to show variation in the chromosome number and pairing in meiosis. We used an air-drying method, which was more reliable for chromosome preparations from fresh animal tissues than a squash method....
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00053-2
更新日期：2000-12-01 00:00:00
abstract：:The asexual blood stages of the Plasmodium falciparum parasite are responsible for inducing the clinical symptoms and the most severe presentations of malaria infection that causes frequent mortality and morbidity in tropical and subtropical areas of the world, making the blood stages of infection a key target of new ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.05.012
更新日期：2018-10-01 00:00:00
abstract：:To evaluate the geographic distribution of Giardia intestinalis genotypes in Nablus, West Bank, Palestine, a genotyping study was performed using clinical fecal samples. Microscopic examination confirmed that 8 of 69 (11.6%) samples were G. intestinalis positive, and subsequent genotyping analyses targeting the small-...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.04.002
更新日期：2009-09-01 00:00:00
abstract：:This study aims to detect the antischistosomal properties of the plants' Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban methanol extract against Schistosoma mansoni in infected mice, including determination of total protein and albumin levels and the activities of alanine and aspartate transaminases ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.06.016
更新日期：2011-12-01 00:00:00
abstract：:The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units. The glycosyltransferase TbGT8 is involved in the synthesis of the branched side chain through its ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.01.007
更新日期：2014-06-01 00:00:00
abstract：:This report describes a rare case of ophthalmic dirofilariasis in a 2-year-old boy with redness, irritation, pain and foreign body sensation in the right eye. Slit lamp examination demonstrated a thread-like whitish nematode in the anterior chamber of the right eye that twisted around itself. The nematode worm (35mm l...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2016.10.022
更新日期：2017-02-01 00:00:00
abstract：:Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternative...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.06.005
更新日期：2015-10-01 00:00:00
abstract：:Opisthorchiasis caused by the carcinogenic liver fluke Opisthorchis viverrini is a major foodborne parasitic zoonotic disease in Thailand and neighboring Mekong countries. The infection is associated with several hepatobiliary diseases including cholangiocarcinoma (CCA). The rates of CCA in regions where the parasite ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2016.11.013
更新日期：2017-08-01 00:00:00
abstract：:The raccoon dog (Nyctereutes procyonoides viverrinus) is known to acquire canine heartworm (Dirofilaria immitis) infection. We surveyed the prevalence of heartworm infection in free-ranging raccoon dogs in the Nishi-Tama (Tokyo) and Kanagawa areas of Japan. A total of 75 raccoon dog carcasses, including 29 animals fro...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00049-0
更新日期：2000-09-01 00:00:00
abstract：:In murine leishmaniasis, the induction of the T-helper type 1 (Th1) response contributes to infection resistance, whereas the establishment of the Th2 response makes the mice susceptible to infection. Interleukin-12 (IL-12) plays a pivotal role in the diversification of immune responses to the Th1 type. In this study,...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00070-8
更新日期：2001-07-01 00:00:00
abstract：:Human intestinal sarcocystosis (HIS), caused by Sarcocystis species, is acquired by eating undercooked meat from sarcocyst-containing cattle (S. hominis, S. heydorni) and pigs (S. suihominis). We report on the detection of human intestinal Sarcocystis infections in a cross-sectional survey of Strongyloides stercoralis...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.04.010
更新日期：2017-10-01 00:00:00
abstract：:A survey was carried out to investigate the occurrence of Sarcocystis infection in the loin (Musculus longissimus) of Japanese and imported beef. In all, the muscle tissue of 482 samples were examined by histological method. The prevalence of Sarcocystis unspecified species cysts was lower in Japanese beef (total 6.31...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(98)00041-5
更新日期：1999-03-01 00:00:00
abstract：:Toxoplasma gondii takes two different life cycle stages within intermediate hosts including humans. Tachyzoites proliferate during the acute stage, and they transform into cysts to establish a chronic infection preferentially in the brain. IFN-γ production by infiltrated CD4+ and CD8+ T cells is required for the preve...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2019.102030
更新日期：2020-06-01 00:00:00
abstract：:Seven experiments were carried out to test the hypothesis that concurrent infection with the chronic and immunomodulatory intestinal nematode parasites, Heligmosomoides polygyrus, and the piroplasm, Babesia microti, would result in more intense and long-lasting infections with the hemoprotozoan. However, despite varia...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(99)00014-8
更新日期：1999-08-01 00:00:00
