Abstract：
:A schistosome genome project was initiated by the World Health Organization in 1994 with the notion that the best prospects for identifying new targets for drugs, vaccines, and diagnostic development lie in schistosome gene discovery, development of chromosome maps, whole genome sequencing and genome analysis. Schistosoma mansoni has a haploid genome of 270 Mb contained on 8 pairs of chromosomes. It is estimated that the S. mansoni genome contains between 15000 and 25000 genes. There are approximately 16689 ESTs obtained from diverse libraries representing different developmental stages of S. mansoni, deposited in the NCBI EST database. More than half of the deposited sequences correspond to genes of unknown function. Approximately 40-50% of the sequences form unique clusters, suggesting that approximately 20-25% of the total schistosome genes have been discovered. Efforts to develop low resolution chromosome maps are in progress. There is a genome sequencing program underway that will provide 3X sequence coverage of the S. mansoni genome that will result in approximately 95% gene discovery. The genomics era has provided the resources to usher in the era of functional genomics that will involve microarrays to focus on specific metabolic pathways, proteomics to identify relevant proteins and protein-protein interactions to understand critical parasite pathways. Functional genomics is expected to accelerate the development of control and treatment strategies for schistosomiasis.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
LoVerde PT,Hirai H,Merrick JM,Lee NH,El-Sayed Ndoi
10.1016/j.parint.2004.01.009subject
Has Abstractpub_date
2004-06-01 00:00:00pages
183-92issue
2eissn
1383-5769issn
1873-0329pii
S1383576904000108journal_volume
53pub_type
杂志文章,评审abstract：:Granuloma modulation induced by antigen is an attractive model for vaccination studies of experimental schistosomiasis to test the effect of anti-pathology vaccine. We describe here an immunization procedure with culture derived macrophages-pulsed PIII, a known anionic antigen purified from S. mansoni adult worm, invo...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(02)00031-4
更新日期：2002-09-01 00:00:00
abstract：:Three species of the genus Allocreadium were collected from cyprinid fish in the territory of the Russian Far East: Allocreadium khankaiensis sp.nov; Allocreadium hemibarbi Roitman, 1963, and Allocreadium sp. 1. It is established that, according to morphometric values, the species A. khankaiensis sp.nov. has high morp...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102102
更新日期：2020-06-01 00:00:00
abstract：:Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.01.001
更新日期：2017-04-01 00:00:00
abstract：:Adult trematodes of the genus Gonocerca Manter, 1925, are parasites of marine fishes. Identification of the phylogenetic positions and a revision of the taxonomic status of the subfamily Gonocercinae Skrjabin et Guschanskaja, 1955 (Derogenidae) are the main purposes of this research article. Four Gonocerca species wer...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.03.007
更新日期：2018-02-01 00:00:00
abstract：:The role of neutrophils in mediating host inflammation was examined in mice vaccinated with living third-stage infective hookworm larvae (L3). Mice were vaccinated by oral immunization with 500 L3 (Ancylostoma caninum) once every 2 weeks for a total of three immunizations. The vaccinated mice were then challenged intr...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(01)00081-2
更新日期：2001-11-01 00:00:00
abstract：:Giardia duodenalis represents one of the most widespread human enteric parasites: about 200million people in Asia, Africa and Latin America are infected. Giardia exerts a deep impact on public health because of high prevalence and possible effects on growth and cognitive functions in infected children. The major aim o...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.11.004
更新日期：2014-04-01 00:00:00
abstract：:Tick-borne protozoan and rickettsial diseases are a major threat to livestock in tropical and sub-tropical regions of Africa. In this study we investigated the presence and distribution of Theileria spp., Babesia ovis, Anaplasma ovis, Anaplasma phagocytophilum, Ehrlichia ruminantium and SFG Rickettsia in sheep and goa...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.11.002
更新日期：2018-04-01 00:00:00
abstract：:Genetic diversity of Plasmodium falciparum is intimately associated with morbidity, mortality and malaria control strategies. It is therefore imperative to study genetic makeup and population structure of this parasite in endemic areas. In Kong Mong Tha, an isolated village in western Thailand, the majority of P. falc...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.09.011
更新日期：2015-06-01 00:00:00
abstract：:Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.09.001
更新日期：2013-02-01 00:00:00
abstract：:mRNA and protein expression profiles for three peroxiredoxins (TPx-1, TPx-2 and 1-Cys Prx) of liver stage Plasmodium berghei were examined through quantitative reverse transcription-PCR (RT-PCR) and indirect immunofluorescence microscopy assay (IFA). RT-PCR experiments revealed that mRNA expression for the TPx-1 was d...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.11.007
更新日期：2013-06-01 00:00:00
abstract：:Newly collected material of Cercopithifilaria rugosicauda from roe deer Capreolus capreolus was analysed and compared to descriptions of C. rugosicauda from Austria and Hungary. The present specimens were assigned to the genus Cercopithifilaria using both morphological and molecular analyses. Complementary morphologic...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.07.011
更新日期：2014-12-01 00:00:00
abstract：:In Shiqu County of the Qinghai-Tibet plateau, many wild and domestic mammals are involved in the transmission cycles of Echinococcus spp. Echinococcus multilocularis and Echinococcus granulosus genotype G1 (sheep strain) are sympatrically distributed in the plateau. In 1995, we identified a unique strobilate stage of ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.035
更新日期：2006-01-01 00:00:00
abstract：:Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multipl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.002
更新日期：2009-12-01 00:00:00
abstract：:The asexual erythrocytic cycle of the protozoan parasite Plasmodium falciparum is responsible for the pathogenesis of malaria and causes the overwhelming majority of malaria deaths. Rapidly increasing parasitaemia during this 48hour cycle threatens the survival of the human host and the parasite prior to transmission ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.07.007
更新日期：2016-12-01 00:00:00
abstract：:This review analyzes the literature in search of an answer to the fact that, in general, tapeworms are very difficult to recover. The results and comments of the authors that have searched for Taenia solium, either to define the local prevalence in different countries of Latin America, to assess the efficacy of cestoc...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.018
更新日期：2006-01-01 00:00:00
abstract：:It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites. Furthermore, the N-terminal recombinant SER...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00040-4
更新日期：2000-08-01 00:00:00
abstract：:Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of parasitized red blood cells (PRBCs) mediate adhesion of PRBCs to host vascular endothelial receptors and is considered responsible for pathogenesis of severe P. falciparum malaria. The present study was undertaken to measure cell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.11.003
更新日期：2007-03-01 00:00:00
abstract：:The clinical features of neurocysticercosis (NCC) largely depend on the number, type, size, localization and stage of development of cysticerci, as well as on the host immune response against the parasite. Seizures are widely reported to be the most common symptom, occurring in 70-90% of patients, while NCC is conside...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.016
更新日期：2006-01-01 00:00:00
abstract：:Chromosome analyses were performed on three races (alpha, beta, gamma) of Neotricula aperta which were previously reported to show variation in the chromosome number and pairing in meiosis. We used an air-drying method, which was more reliable for chromosome preparations from fresh animal tissues than a squash method....
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00053-2
更新日期：2000-12-01 00:00:00
abstract：:Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternative...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.06.005
更新日期：2015-10-01 00:00:00
abstract：:A new sanguinicolid blood fluke, Cardicola orientalis n. sp., is described from the afferent branchial artery and heart of Pacific bluefin tuna Thunnus orientalis (Temminck & Schlegel) cultured in Mie and Nagasaki Prefectures, Japan. The new species is most similar to C. ambrosioi Braicovich, Etchegoin, Timi et Sardel...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.10.003
更新日期：2010-03-01 00:00:00
abstract：:Human fascioliasis cases in Japan have been reported infrequently and the most appropriate therapy for this disease remains to be determined. This case report describes a patient with the infection unsuccessfully treated with multiple high doses of praziquantel for over 1 year and eventually cured by the administratio...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(02)00004-1
更新日期：2002-06-01 00:00:00
abstract：:The advances in microscopy combined to the invaluable progress carried by the utilization of molecular, immunological or immunochemical markers and the implementation of more powerful imaging technologies have yielded great improvements to the knowledge of the interaction between microorganisms and their hosts, notabl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.07.011
更新日期：2014-02-01 00:00:00
abstract：:Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102203
更新日期：2021-02-01 00:00:00
abstract：:Owing to the need to combat the spread of acaricide-resistant ticks, the development of long-term biological control has become a hot topic for tick control. In this study, we investigated the pathogenicity of three Beauveria bassiana isolates on the engorged female Rhipicephalus (Boophilus) microplus ticks using diff...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.04.008
更新日期：2013-10-01 00:00:00
abstract：:The necropsy of an adult male leopard, Panthera pardus, shot in the Kruger National Park, revealed the presence of large numbers of Armillifer armillatus nymphs in the intestine, liver, spleen, mesentery, peritoneal fold, mediastinum and lungs. The animal had been observed to be blind in the right eye and severely deb...
journal_title：Parasitology international
pub_type：
doi：10.1016/j.parint.2019.102029
更新日期：2020-06-01 00:00:00
abstract：:Cryptosporidium and Enterocytozoon bieneusi are the most prevalent protist pathogens responsible for inducing human and animal diseases worldwide. The aim of the present work was to determine the occurrence of Cryptosporidium spp. and E. bieneusi in pet chinchillas in China. One hundred forty fecal samples were collec...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.05.007
更新日期：2015-10-01 00:00:00
abstract：:Host cell invasion is the only step where Babesia parasites are extracellular, and their survival is menaced during this step. Therefore, interfering with this critical stage is a target for an anti-Babesia intervention strategy. In this regard, recombinant protein encoding Babesia divergens Erythrocyte Binding Protei...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.07.004
更新日期：2017-12-01 00:00:00
abstract：:Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the pericarp and fruit of Garcinia mangostana and of the synthetic derivative mangostin diacetate. Mangostin and mangostin d...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.01.004
更新日期：2012-06-01 00:00:00
abstract：:The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.004
更新日期：2015-04-01 00:00:00
