Abstract：
:The advances in microscopy combined to the invaluable progress carried by the utilization of molecular, immunological or immunochemical markers and the implementation of more powerful imaging technologies have yielded great improvements to the knowledge of the interaction between microorganisms and their hosts, notably a better understanding of the establishment of infectious processes. Still today, the intricacies of the dialog between parasites, cells and tissues remain limited. Some improvements have been attained with the stable integration and expression of the green fluorescence protein or firefly luciferase and other reporter genes, which have allowed to better approach the monitoring of gene expression and protein localization in vivo, in situ and in real time. Aiming at better exploring the well-established models of murine infections with the characterized strains of Trypanosoma cruzi and Trypanosoma vivax, we revisited in the present report the state of the art about the tools for the imaging of Trypanosomatids in vitro and in vivo and show the latest transgenic parasites that we have engineered in our laboratory using conventional transfection methods. The targeting of trypanosomes presented in this study is a promising tool for approaching the biology of parasite interactions with host cells, the progression of the diseases they trigger and the screening of new drugs in vivo or in vitro.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Goyard S,Dutra PL,Deolindo P,Autheman D,D'Archivio S,Minoprio Pdoi
10.1016/j.parint.2013.07.011subject
Has Abstractpub_date
2014-02-01 00:00:00pages
260-8issue
1eissn
1383-5769issn
1873-0329pii
S1383-5769(13)00112-8journal_volume
63pub_type
杂志文章abstract：:The taxonomic framework of Ligophorus, monogenean specialists of the gills of grey mullets (Mugilidae), is evaluated and its interspecific relationships are assessed for the first time using molecular data. The position of Ligophorus within the paraphyletic Ancyrocephalinae is re-assessed based on newly sequenced spec...
journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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