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Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds.

Abstract：

:The anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction (50°C, 150bar) and the chemical compounds isolated and purified from this extract (benzopyrans HP1, HP2, HP3, and phloroglucinol derivative uliginosin B) were assessed. All samples had anti-T. vaginalis activity; however, HP1 demonstrated the best selectivity against this protozoan (metronidazole-resistant and susceptible isolates), with no cytotoxicity on mammalian cells (selectivity index of 73.97). Moreover, HP1 had activity against a metronidazole-resistant isolate (52% of viable trophozoites), and this effect was higher when tested with a low concentration of metronidazole (23% of viable trophozoites). Experiments demonstrated that all isolated compounds caused damage to the parasites' membrane (>90% of LDH release) and do not present a notable hemolytic effect, although HP2 and uliginosin B exhibited cytotoxicity against mammalian cells. Therefore, the analyzed molecules are promising prototypes for new antiprotozoal drugs, especially HP1, which seems to improve metronidazole's effect on a resistant T. vaginalis isolate.

journal_name

Parasitol Int

journal_title

Parasitology international

authors

Cargnin ST,Vieira Pde B,Cibulski S,Cassel E,Vargas RM,Montanha J,Roehe P,Tasca T,von Poser GL

doi

10.1016/j.parint.2012.10.006

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

112-7

issue

2

eissn

1383-5769

issn

1873-0329

pii

S1383-5769(12)00137-7

journal_volume

62

pub_type

杂志文章

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