Abstract：
:Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment of this condition. Despite of the large number of pediatric patients infected, there are no commercial liquid dosage forms available to treat this trypanosomiasis. This work showed that novel benznidazole-water-polyethylene glycol 400 solutions are active against T. cruzi in a murine model of Chagas' disease. Present results constitute the first demonstration on the usefulness of benznidazole solutions in infected mice.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Manarin R,Lamas MC,Bottasso E,Serra E,Revelli S,Salomón CJdoi
10.1016/j.parint.2012.09.001subject
Has Abstractpub_date
2013-02-01 00:00:00pages
79-81issue
1eissn
1383-5769issn
1873-0329pii
S1383-5769(12)00124-9journal_volume
62pub_type
杂志文章abstract：:We have previously reported a significant decrease in serum PON1 activity after Nippostrongylus brasiliensis infection in Wistar rats in association with the inflammatory response mounted against the parasite in the migratory phase of infection. However, the roles of intestinal phase and the associated oxidative stres...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.03.001
更新日期：2009-06-01 00:00:00
abstract：:This paper presents the morphological, histological, molecular and ultrastructural data on Myxobolus lomi sp. nov., a parasite of the gill filaments of Prochilodus lineatus from the Peixes River (48º06'38″W; 22º 49'53.1″S), São Paulo State, Brazil. From 20 P. lineatus specimens examined, 90.0% (n=18) were infected. Th...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.11.008
更新日期：2014-04-01 00:00:00
abstract：:In the malarial parasite Plasmodium falciparum, the conserved ribosomal stalk protein P2 (PfP2) exhibits extra-ribosomal stage-specific oligomerization and trafficking to the host red cell membrane. Antibodies directed against PfP2 arrested cell division. We sought to examine whether P2 from a closely related Apicompl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.08.006
更新日期：2015-02-01 00:00:00
abstract：:Bovine trypanosomosis is a problem in the livestock industry in Nigeria. A longitudinal survey of cattle sampled during the wet and dry seasons was conducted from April 2016 to March 2017. Blood samples were collected by random sampling from 745 cattle in southwest Nigeria and screened for trypanosomes by internal tra...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.09.005
更新日期：2019-02-01 00:00:00
abstract：:To verify the hypothesis that different pathology of Clonorchis sinensis infection by mouse strains is determined by different responses of cytokines and chemokines, we compared those responses of FVB with those of BALB/c mice. All of FVB mice infected with 30 metacercariae of C. sinensis showed cystic dilatation in t...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.07.001
更新日期：2012-03-01 00:00:00
abstract：:Intestinal mucous cell numbers and their glycoconjugate composition were investigated by histochemical methods in uninfected chub, Squalius cephalus, and in conspecifics naturally parasitised with the acanthocephalan Pomphorhynchus laevis. A sub-population of 42 chub from the River Tiber (Perugia, Italy) were sampled ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.018
更新日期：2015-04-01 00:00:00
abstract：:Fasciola flukes from eastern India were characterized on the basis of spermatogenesis status and nuclear ITS1. Both Fasciola gigantica and aspermic Fasciola flukes were detected in Imphal, Kohima, and Gantoku districts. The sequences of mitochondrial nad1 were analyzed to infer their phylogenetical relationship with n...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.04.004
更新日期：2015-10-01 00:00:00
abstract：:Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic functions. PoDHFR-TS w...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.12.004
更新日期：2012-06-01 00:00:00
abstract：:Diplozoids (Diplozoidae, Monogenea) are fish ectoparasites with a direct life cycle without intermediate hosts. Their free swimming larva, the oncomiracidium, hatches from eggs, invades a fish host and metamorphoses into a post-oncomiracidial larval stage, the diporpa. Later, two diporpae fuse and live as a pair in cr...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.01.010
更新日期：2007-09-01 00:00:00
abstract：:Adult trematodes of the genus Gonocerca Manter, 1925, are parasites of marine fishes. Identification of the phylogenetic positions and a revision of the taxonomic status of the subfamily Gonocercinae Skrjabin et Guschanskaja, 1955 (Derogenidae) are the main purposes of this research article. Four Gonocerca species wer...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.03.007
更新日期：2018-02-01 00:00:00
abstract：:Muscular sarcocystosis by Sarcocystis arctica was found for the first time in the Czech Republic, in different muscles of red fox (Vulpes vulpes). Cysts were slim, elongated, thread-like, whitish, 1-7mm long, and 206-270μm wide; bradyzoites were 7.9×2.7μm in unstained wet mounts and 9.2×2.9μm in cyst Giemsa-stained sm...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.05.003
更新日期：2017-10-01 00:00:00
abstract：:The presence of iron in the extracellular medium is essential for both in vivo and in vitro survival of pathogenic microorganisms, including Trichomonas vaginalis and Tritrichomonas foetus. In these parasites, iron is directly involved in the proliferation, protein expression and activation of critical enzymes. The pu...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.08.002
更新日期：2006-12-01 00:00:00
abstract：:The pathogen Borrelia burgdorferi causes Lyme Borreliosis in human and animals world-wide. In Europe the pathogen is transmitted to the host by the vector Ixodes ricinus. The nymph is the primary instar for transmission to humans. We here study the infection rate of five Borrelia genospecies: B. burgdorferi sensu stri...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.07.004
更新日期：2008-03-01 00:00:00
abstract：:Genetic diversity of Plasmodium falciparum is intimately associated with morbidity, mortality and malaria control strategies. It is therefore imperative to study genetic makeup and population structure of this parasite in endemic areas. In Kong Mong Tha, an isolated village in western Thailand, the majority of P. falc...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.09.011
更新日期：2015-06-01 00:00:00
abstract：:Control of morbidity associated with schistosomiasis via chemotherapy largely relies on the drug praziquantel. Repeated therapy with praziquantel has created concerns about the possible selection of resistant worms and necessitated the search for novel drugs to treat schistosomiasis. Here, a murine model was infected ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.03.006
更新日期：2018-08-01 00:00:00
abstract：:Dioctophymosis is the disease caused by the nematode Dioctophyme renale, normally found parasitizing the right kidney of dogs. The absence of symptoms is frequent in parasitized animals. The surgical procedures are commonly performed to treat this disease. This work describes a case involving a canine with renal and e...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102211
更新日期：2021-02-01 00:00:00
abstract：:A case of fatal infection caused by larval forms of Taenia martis in a ring-tailed lemur (Lemur catta) living in the Rome zoological garden is described. The animal, living in a semi-natural pen with other 15 conspecific individuals and being fed with fresh fruit and vegetables, yoghurt and eggs, was transported to th...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.05.008
更新日期：2014-10-01 00:00:00
abstract：:This review analyzes the literature in search of an answer to the fact that, in general, tapeworms are very difficult to recover. The results and comments of the authors that have searched for Taenia solium, either to define the local prevalence in different countries of Latin America, to assess the efficacy of cestoc...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.018
更新日期：2006-01-01 00:00:00
abstract：:It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites. Furthermore, the N-terminal recombinant SER...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00040-4
更新日期：2000-08-01 00:00:00
abstract：:Dientamoeba fragilis is an intestinal protozoan, an inhabitant of the human gastrointestinal tract, with a worldwide distribution. The reported prevalence of D. fragilis varies worldwide in different populations between 0.3% and 82.9%, and its role as a pathogen is still unclear. The parasite has been identified in th...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102227
更新日期：2021-02-01 00:00:00
abstract：:Paragonimiasis is a typical food-borne parasitic disease, endemic in most parts of Asia, with sporadic case reports from American and African countries. The major source of infection is undercooked freshwater crab or crayfish, though consumption of wild boar meat is also responsible for the infection in Japan, because...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：:The accurate characterization of Schistosoma japonicum has important implications for analyzing genetic variation and would provide basic data for disease control. Previous studies using proteins, coding sequences, and especially antigen-coding genes showed lower genetic variation among S. japonicum isolates from main...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.01.008
更新日期：2011-06-01 00:00:00
abstract：:Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102203
更新日期：2021-02-01 00:00:00
abstract：:The liver fluke, Opisthorchis viverrini, causes serious public-health problems in the Lower Mekong Basin. This study aimed to clarify whether O. viverrini populations may be genetically divided into sub-specific taxa. We collected 6 populations of O. viverrini from different places in Cambodia, Lao PDR, and Thailand, ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.02.009
更新日期：2010-06-01 00:00:00
abstract：:The objective of this study was to determine the level of resistance of Haemonchus contortus and Trichostrongylus colubriformis in sheep to levamisole, albendazole, ivermectin, moxidectin, closantel and trichlorfon. The parasites were isolated from sheep naturally infected by gastrointestinal nematodes and were then k...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.09.006
更新日期：2010-12-01 00:00:00
abstract：:The parasite Entamoeba histolytica causes intestinal amebiasis and amebic liver abscess as its main extraintestinal manifestation. To study the in vivo events related to inflammation and the interactions between hosts and parasites during amebiasis, we designed a novel model of host-parasite interactions using cellulo...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.08.009
更新日期：2016-12-01 00:00:00
abstract：:Host cell invasion is the only step where Babesia parasites are extracellular, and their survival is menaced during this step. Therefore, interfering with this critical stage is a target for an anti-Babesia intervention strategy. In this regard, recombinant protein encoding Babesia divergens Erythrocyte Binding Protei...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.07.004
更新日期：2017-12-01 00:00:00
abstract：:Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the pericarp and fruit of Garcinia mangostana and of the synthetic derivative mangostin diacetate. Mangostin and mangostin d...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.01.004
更新日期：2012-06-01 00:00:00
abstract：:The parasite Giardia intestinalis undergoes a differentiation process that allows it to infect its mammal host. That process is excystation. We examined the importance of protein phosphorylation during the passage from cyst to trophozoite. Cysts obtained from patients with giardiasis were excysted in vitro and the sol...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.10.005
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND/AIMS:The aim of this study was to determine the prevalence and significance of intestinal protozoa, specially Blastocystis spp., and to perform PCR-based subtype classification for understanding the importance of Blastocystis spp. in the pathogenesis of gastrointestinal disorders in post-traumatic splenectom...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.12.004
更新日期：2016-12-01 00:00:00
