Abstract：
:Control of morbidity associated with schistosomiasis via chemotherapy largely relies on the drug praziquantel. Repeated therapy with praziquantel has created concerns about the possible selection of resistant worms and necessitated the search for novel drugs to treat schistosomiasis. Here, a murine model was infected with Schistosoma mansoni and treated with oral 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89), which caused a significant reduction in fecundity and egg burden and reduced morbidity when administered at 5-weeks post-infection. The analysis showed that the mode of action occurred through the ingestion of activated N-89 by the worms, and that there was no direct external effect on the S. mansoni worms. Ultrastructural analysis of the treated worms showed disruptions in the gut lumen and the presence of large volumes of material, suggestive of undigested blood meals or red blood cells. In addition, there were reduced vitelline cells in female worms and damage to sub-tegmental musculature in male worms. Eggs recovered from the treated mice showed both damage to the eggs and the production of immature eggs. Expression of mRNA responsible for gut and digestive function and egg production was also significantly affected by N-89 treatment, whereas control genes for musculature showed no significant changes. Thus, N-89 drastically affected the total digestive function and egg production of S. mansoni worms. Physiological processes requiring heme uptake such as egg production and eggshell formation were subsequently affected, suggesting that the compound could be a possible therapeutic drug candidate for schistosomiasis control.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Blay EA,Kumagai T,Yamabe M,Hino A,Shimogawara R,Kim HS,Sato A,Ichimura K,Ayi I,Iwanaga S,Ohta Ndoi
10.1016/j.parint.2018.03.006subject
Has Abstractpub_date
2018-08-01 00:00:00pages
403-412issue
4eissn
1383-5769issn
1873-0329pii
S1383-5769(17)30495-6journal_volume
67pub_type
杂志文章abstract：:The raccoon dog (Nyctereutes procyonoides viverrinus) is known to acquire canine heartworm (Dirofilaria immitis) infection. We surveyed the prevalence of heartworm infection in free-ranging raccoon dogs in the Nishi-Tama (Tokyo) and Kanagawa areas of Japan. A total of 75 raccoon dog carcasses, including 29 animals fro...
journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
pub_type： 杂志文章
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更新日期：2012-12-01 00:00:00
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journal_title：Parasitology international
pub_type： 杂志文章,评审
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更新日期：1999-03-01 00:00:00
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
pub_type： 杂志文章
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journal_title：Parasitology international
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journal_title：Parasitology international
pub_type： 杂志文章,评审
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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journal_title：Parasitology international
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abstract：:The objective of this study was to determine the level of resistance of Haemonchus contortus and Trichostrongylus colubriformis in sheep to levamisole, albendazole, ivermectin, moxidectin, closantel and trichlorfon. The parasites were isolated from sheep naturally infected by gastrointestinal nematodes and were then k...
journal_title：Parasitology international
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
abstract：:The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units. The glycosyltransferase TbGT8 is involved in the synthesis of the branched side chain through its ...
journal_title：Parasitology international
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
