Abstract:
:Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro parasite growth assay based on the green fluorescent protein (GFP) signal, P. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (IC50 of GFP-expressing N. caninum parasites, 22.1μg/ml). The P. betle extract, at 25μg per ml, inhibited parasite invasion into host cells. Furthermore, in two independent experiments, treating N. caninum-infected mice with the P. betle extract for 7days post-infection increased their survival. In trial one, the anti-N. caninum effects of the P. betle extract reduced the mouse clinical scores for 30days post-infection (dpi). The survival rate of the mice treated with 400mg/kg was 100% compared with 66.6% for those treated with 100mg/kg and the non-treated controls. In trial two, treating the infected mice with the P. betle extract increased their survival at 50dpi. All mice in the non-treatment group died; however, the survival rates of the 400mg/kg-treated and 100mg/kg-treated mice were 83.3% and 33.3%, respectively. Also, a trend towards a reduced parasite burden was noted in the brains of the P. betle extract-treated mice, compared with the control mice. Therefore P. betle extract has potential as a medicinal plant for treating neosporosis.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Leesombun A,Boonmasawai S,Nishikawa Ydoi
10.1016/j.parint.2017.01.017subject
Has Abstractpub_date
2017-06-01 00:00:00pages
219-226issue
3eissn
1383-5769issn
1873-0329pii
S1383-5769(16)30277-Xjournal_volume
66pub_type
杂志文章abstract::The phospholipid metabolism of Plasmodium falciparum-infected erythrocytes has been shown to be an effective pharmacological target for novel chemotherapy. Thirty-seven monoquaternary ammonium derivatives analogous to choline were screened for their potential antiprotozoal activity against P. falciparum and Leishmania...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2007.09.006
更新日期:2008-06-01 00:00:00
abstract::It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites. Furthermore, the N-terminal recombinant SER...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(00)00040-4
更新日期:2000-08-01 00:00:00
abstract::The outcome of Plasmodium yoelii 17XL (P.y17XL)-infected BALB/c and DBA/2 mice, ranging from death to spontaneous cure, depends largely on the establishment of effective Th1 and Th2 responses and a successful switch between Th1 and Th2 responses, as well as appropriate functioning of CD4(+)CD25(+)Foxp3(+)regulatory T ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2010.05.005
更新日期:2010-09-01 00:00:00
abstract::The advances in microscopy combined to the invaluable progress carried by the utilization of molecular, immunological or immunochemical markers and the implementation of more powerful imaging technologies have yielded great improvements to the knowledge of the interaction between microorganisms and their hosts, notabl...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2013.07.011
更新日期:2014-02-01 00:00:00
abstract::Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multipl...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.07.002
更新日期:2009-12-01 00:00:00
abstract::The asexual blood stages of the Plasmodium falciparum parasite are responsible for inducing the clinical symptoms and the most severe presentations of malaria infection that causes frequent mortality and morbidity in tropical and subtropical areas of the world, making the blood stages of infection a key target of new ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2018.05.012
更新日期:2018-10-01 00:00:00
abstract::Two hyperapolytic species of Acanthobothrium Blanchard, 1848 have been collected from Discopyge tschudii Heckel, 1846 and Zapteryx brevirostris (Müller et Henle) along the coast of Argentina. Acanthobothrium stefaniae sp. n. from D. tschudii is a category one species (i.e., it is less than 15 mm in total length, posse...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2018.04.001
更新日期:2018-08-01 00:00:00
abstract::Gyrodactylus medaka n. sp. (Monogenea: Gyrodactylidae) is described from the skin, fins, and gills of medaka Oryzias latipes (Beloniformes: Adrianichthyidae) from Japan. This new species was collected from wild medaka in Hiroshima, Aichi, Saga, and Kumamoto prefectures, and laboratory-reared medaka in Chiba and Aichi ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2018.06.010
更新日期:2018-10-01 00:00:00
abstract::The presence of antibodies to Toxoplasma gondii in livestock and poultry was investigated by latex agglutination tests; samples that agglutinated at dilutions of 1:64 or higher were regarded as positive. Sera were collected from fattening beef cattle (102 Japanese black, 105 crossbreeds and 114 castrated Holstein), cu...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2014.04.003
更新日期:2014-08-01 00:00:00
abstract::Three species of the genus Capsala including Capsala naffari n. sp., C. neothunni (Yamaguti, 1968) and C. nozawae (Goto, 1894) are recorded and described from the buccal cavity of mackerel tuna Euthynnus affinis caught from Emirate coasts. Capsala naffari can be differentiated by its lateral spiniform teeth, which ext...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(02)00033-8
更新日期:2002-12-01 00:00:00
abstract::A recombinant pore-forming peptide of Clonorchis sinensis, clonorin, was evaluated for serodiagnostic reagent of clonorchiasis by enzyme-linked immunosorbent assay detecting IgG antibody. Recombinant clonorin showed 100% specificity and low sensitivity for sera of human clonorchiasis. In contrast, C. sinensis crude an...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(03)00002-3
更新日期:2003-06-01 00:00:00
abstract::Adult trematodes of the genus Gonocerca Manter, 1925, are parasites of marine fishes. Identification of the phylogenetic positions and a revision of the taxonomic status of the subfamily Gonocercinae Skrjabin et Guschanskaja, 1955 (Derogenidae) are the main purposes of this research article. Four Gonocerca species wer...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.03.007
更新日期:2018-02-01 00:00:00
abstract::Plasmodial bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a validated antimalarial drug target. In this study, expression of the putative dhfr-ts of Plasmodium ovale rescued the DHFR chemical knockout and a TS null bacterial strain, demonstrating its DHFR and TS catalytic functions. PoDHFR-TS w...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2011.12.004
更新日期:2012-06-01 00:00:00
abstract::The life cycle of Coitocoecum plagiorchis Ozaki, 1926 (Coitocaecum is an incorrect subsequent spelling) was studied in the field and laboratory. The study was conducted at the Futatsu River and the Chikugo River, Kyushu, Japan. Adults of C. plagiorchis were obtained from fishes Coreoperca kawamebari, Rhinogobius spp. ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2005.06.004
更新日期:2005-12-01 00:00:00
abstract::Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternative...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2015.06.005
更新日期:2015-10-01 00:00:00
abstract::Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2012.09.001
更新日期:2013-02-01 00:00:00
abstract::Gnathostomiasis is an emerging zoonosis in Mexico. However, for most endemic zones, the source of human infection has not been established. During 2000-2003, we investigated 2168 vertebrates (2047 fish, 31 amphibians, 4 reptiles, 19 birds and 67 mammals) from 39 localities distributed in nine states. We registered 7 v...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2004.10.001
更新日期:2005-03-01 00:00:00
abstract::Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic c...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2007.08.001
更新日期:2008-03-01 00:00:00
abstract::Infections with parasites, such as Strongyloides stercoralis, typically cause elevated levels of serum immunoglobulin E (IgE) and eosinophils; however, co-infection with human T cell lymphotropic virus type 1 (HTLV-1) can cause lower levels of serum IgE during S. stercoralis infection. We conducted this study to deter...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2016.10.004
更新日期:2017-02-01 00:00:00
abstract::Three different monoclonal antibodies were produced against Trypanosona cruzi proteasomes. These antibodies were shown to react with a single 27-kDa band on immunoblots of purified proteasomes. Using a 7E5 monoclonal antibody (IgG1) that recognized the alpha5 subunit of protozoan protease we have studied the intracell...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.07.012
更新日期:2009-12-01 00:00:00
abstract::Cryptosporidium and Enterocytozoon bieneusi are the most prevalent protist pathogens responsible for inducing human and animal diseases worldwide. The aim of the present work was to determine the occurrence of Cryptosporidium spp. and E. bieneusi in pet chinchillas in China. One hundred forty fecal samples were collec...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2015.05.007
更新日期:2015-10-01 00:00:00
abstract::Bovine trypanosomosis is a problem in the livestock industry in Nigeria. A longitudinal survey of cattle sampled during the wet and dry seasons was conducted from April 2016 to March 2017. Blood samples were collected by random sampling from 745 cattle in southwest Nigeria and screened for trypanosomes by internal tra...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2018.09.005
更新日期:2019-02-01 00:00:00
abstract::The prevalence of Theileria equi and Babesia caballi was determined in equid blood samples in five provinces of the Black Sea region of Turkey by using the indirect fluorescent antibody test (IFAT). Of 153 samples, 53 (34.6%) and 33 (21.5%) were seropositive to B. caballi and T. equi, respectively. In addition, 8 (5.2...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2007.12.009
更新日期:2008-06-01 00:00:00
abstract::In Shiqu County of the Qinghai-Tibet plateau, many wild and domestic mammals are involved in the transmission cycles of Echinococcus spp. Echinococcus multilocularis and Echinococcus granulosus genotype G1 (sheep strain) are sympatrically distributed in the plateau. In 1995, we identified a unique strobilate stage of ...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2005.11.035
更新日期:2006-01-01 00:00:00
abstract::Among natural products, sesquiterpenes have shown promising inhibitory effects against bloodstream forms of Trypanosoma brucei, the protozoan parasite causing human African trypanosomiasis (HAT). Smyrnium olusatrum (Apiaceae), also known as Alexanders or wild celery, is a neglected horticultural crop characterized by ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.01.001
更新日期:2017-04-01 00:00:00
abstract::Giardia intestinalis (G. intestinalis) is a flagellate parasite which has been considered the most common protozoan infecting human. Molecular techniques are of great value in studying the taxonomy, the zoonotic potential of animal isolates and the correlation between the genetic variability of the parasite and the ra...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2011.09.006
更新日期:2011-12-01 00:00:00
abstract::We describe the cloning of a full length calpain-encoding cDNA constructed from two truncated cDNAs isolated from a cDNA library prepared with mRNA isolated from adult worms of the Philippine strain of Schistosoma japonicum. The cDNA sequence is 2.456 kb in length and predicts a protein of 758 residues with a molecula...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(99)00021-5
更新日期:2000-01-01 00:00:00
abstract::Gametocytocidal activities of pyronaridine and DNA topoisomerase II inhibitors against two isolates of multidrug-resistant Plasmodium falciparum, KT1 and KT3 were determined. After sorbitol treatment, pure gametocyte cultures of Plasmodium falciparum containing mostly young gametocytes (stage II and III) obtained on d...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(99)00028-8
更新日期:2000-02-01 00:00:00
abstract::The salivary glands of Rhipicephalus sanguineus males at stages: unfed (control), at day seven post-attachment, and at days three and seven post-detachment from the host were examined using methods of enzymatic analysis and cell viability. At these stages of feeding, different staining patterns were observed in the ce...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2008.04.012
更新日期:2008-09-01 00:00:00
abstract::The host-parasite relationship is one of the main themes of modern parasitology. Recent revolutions in science, including the development of various fluorescent proteins/probes and two-photon microscopy, have made it possible to directly visualize and study the mechanisms underlying the interaction between the host an...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2016.02.011
更新日期:2016-10-01 00:00:00