Abstract：
:Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic cell, malaria parasites are likely to utilize members of the peroxiredoxin (Prx) family as the principal enzymes to reduce peroxides, which increase in the parasite cell due to metabolism and parasitism during parasite development. In addition to its function of protecting macromolecules from H(2)O(2), Prx has also been reported to regulate H(2)O(2) as second messenger in transmission of redox signals, which mediate cell proliferation, differentiation, and apoptosis. In the malaria parasite, several lines of experimental data have suggested that the parasite uses Prxs as multifunctional molecules to adapt themselves to asexual and sexual development. In this review, we summarize the accumulated knowledge on the Prx family with respect to their functions in mammalian cells and their possible function(s) in malaria parasites.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Kawazu S,Komaki-Yasuda K,Oku H,Kano Sdoi
10.1016/j.parint.2007.08.001subject
Has Abstractpub_date
2008-03-01 00:00:00pages
1-7issue
1eissn
1383-5769issn
1873-0329pii
S1383-5769(07)00101-8journal_volume
57pub_type
杂志文章,评审abstract：:The liver fluke, Opisthorchis viverrini, causes serious public-health problems in the Lower Mekong Basin. This study aimed to clarify whether O. viverrini populations may be genetically divided into sub-specific taxa. We collected 6 populations of O. viverrini from different places in Cambodia, Lao PDR, and Thailand, ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.02.009
更新日期：2010-06-01 00:00:00
abstract：:We have previously reported a significant decrease in serum PON1 activity after Nippostrongylus brasiliensis infection in Wistar rats in association with the inflammatory response mounted against the parasite in the migratory phase of infection. However, the roles of intestinal phase and the associated oxidative stres...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.03.001
更新日期：2009-06-01 00:00:00
abstract：:Intestinal mucous cell numbers and their glycoconjugate composition were investigated by histochemical methods in uninfected chub, Squalius cephalus, and in conspecifics naturally parasitised with the acanthocephalan Pomphorhynchus laevis. A sub-population of 42 chub from the River Tiber (Perugia, Italy) were sampled ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.018
更新日期：2015-04-01 00:00:00
abstract：:A series of sixteen benzoylthioureas derivatives were initially evaluated in vitro against the epimastigote form of Trypanosoma cruzi. All of the tested compounds inhibited the growth of this form of the parasite, and due to the promising anti-epimastigote activity from three of these compounds, they were also assayed...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102225
更新日期：2021-02-01 00:00:00
abstract：:Plants rich in condensed tannins are an alternative to chemical anthelmintics to control gastrointestinal nematodes (GINs) in ruminants. Previous functional studies have shown that sainfoin extracts affect the two forms of infective larvae (L3), ensheathed and exsheathed. However, the mechanisms of action remain unkno...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2010.09.011
更新日期：2011-12-01 00:00:00
abstract：:Three different monoclonal antibodies were produced against Trypanosona cruzi proteasomes. These antibodies were shown to react with a single 27-kDa band on immunoblots of purified proteasomes. Using a 7E5 monoclonal antibody (IgG1) that recognized the alpha5 subunit of protozoan protease we have studied the intracell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.012
更新日期：2009-12-01 00:00:00
abstract：:Visceral leishmaniasis (VL) is a life-threatening vector borne disease caused by the Leishmania donovani species complex. In Nepal, it is transmitted to humans by L donovani infected Phlebotomus argentipes sand flies [12]. The pathogenesis of VL is complex, and the clinical presentation ranges from asymptomatic infect...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102236
更新日期：2021-02-01 00:00:00
abstract：:The male of Phlebotomus (Larroussius) betisi is described from Malayan caves. Several males have been caught in association with P. betisi females. Males and females have been associated by ecology, biogeography, morphology and molecular biology (homology of the ND4 mtDNA sequences). ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.01.003
更新日期：2008-09-01 00:00:00
abstract：:A strategy to engineer a strain of Culex mosquitoes refractory to filarial transmission is described. A requirement for success of the strategy is identification of a flight muscle-specific promoter that functions in the mosquito. A GFP marker gene under the control of the promoter region of the Drosophila melanogaste...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2004.04.002
更新日期：2004-12-01 00:00:00
abstract：:Several Sarcocystis spp. have carnivores as definitive host and sarcocysts are common in muscles of herbivores (intermediate host). However, sarcocysts have been found in muscles of wild and domestic carnivores suggesting they are intermediate host for some Sarcocystis spp. Here, we report mature sarcocysts in the mus...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.01.021
更新日期：2017-06-01 00:00:00
abstract：:Schistosomiasis is endemic in Indonesia in two isolated areas, Lindu valley and Napu valley, both located in the Province of Central Sulawesi. In 1940, a prevalence survey was initiated in Lake Lindu, which indicated a Schistosoma japonicum infection prevalence of 56% among the population of Anca, Tomado and Langko vi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.04.008
更新日期：2008-09-01 00:00:00
abstract：:The clinical features of neurocysticercosis (NCC) largely depend on the number, type, size, localization and stage of development of cysticerci, as well as on the host immune response against the parasite. Seizures are widely reported to be the most common symptom, occurring in 70-90% of patients, while NCC is conside...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.016
更新日期：2006-01-01 00:00:00
abstract：:Henneguya guanduensis was originally described as a gill parasite of the Hoplosternum litoralle, a siluriform fish belonging to the Callichthyidae family. A study was undertaken with 58 specimens of H. litoralle taken from Batalha River in the state of São Paulo. The fish were collected and examined searching for lesi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.01.009
更新日期：2019-06-01 00:00:00
abstract：:Control of morbidity associated with schistosomiasis via chemotherapy largely relies on the drug praziquantel. Repeated therapy with praziquantel has created concerns about the possible selection of resistant worms and necessitated the search for novel drugs to treat schistosomiasis. Here, a murine model was infected ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.03.006
更新日期：2018-08-01 00:00:00
abstract：:Acanthocephalans of the order Echinorhynchida are one of the most diverse groups in their phylum, with approximately 470 species classified into 11 families that largely consist of parasites of freshwater, brackish and marine fishes and, sporadically, reptiles and amphibians distributed worldwide. Previous phylogenies...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102264
更新日期：2020-12-07 00:00:00
abstract：:"Below is an essay by Prof. Tanabe originally written in Japanese. It gives an insight to Prof. Tanabe's inquiring mind and his approach to science. He also seek, as always, to inspire and nudge the young to scientific discovery". ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2014.11.010
更新日期：2015-06-01 00:00:00
abstract：:Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.09.011
更新日期：2015-06-01 00:00:00
abstract：:Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of parasitized red blood cells (PRBCs) mediate adhesion of PRBCs to host vascular endothelial receptors and is considered responsible for pathogenesis of severe P. falciparum malaria. The present study was undertaken to measure cell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.11.003
更新日期：2007-03-01 00:00:00
abstract：:Autophagy is a homeostatic process promoting cell survival in periods of stress. The induction of the autophagic machinery has also been implicated in both innate and adaptive immunity. Leishmania donovani, which is the causative pathogen of visceral leishmaniasis, is an intracellular parasite that invades and multipl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.002
更新日期：2009-12-01 00:00:00
abstract：:Taeniasis/cysticercosis has been reported from several provinces of Indonesia: Papua (=former Irian Jaya), Bali, North Sumatra, East Nusa Tenggara, South East Sulawesi, Lampung, North Sulawesi, Jakarta, West Kalimantan, and East Java. The highest level of endemicity of taeniasis/cysticercosis has been found in Papua. ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2005.11.025
更新日期：2006-01-01 00:00:00
abstract：:Tick-borne protozoan and rickettsial diseases are a major threat to livestock in tropical and sub-tropical regions of Africa. In this study we investigated the presence and distribution of Theileria spp., Babesia ovis, Anaplasma ovis, Anaplasma phagocytophilum, Ehrlichia ruminantium and SFG Rickettsia in sheep and goa...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.11.002
更新日期：2018-04-01 00:00:00
abstract：:In this study, we genetically characterised Monogenea found on common carp in Iran. In total, 5603 parasites were recovered from 112 fish. The parasites were first identified morphologically as Dactylogyrus extensus, D. anchoratus, D. vastator, D. minutus, D. achmerowi and Gyrodactylus sprostonae. Representative sampl...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.101977
更新日期：2019-12-01 00:00:00
abstract：:Lymphatic filariasis is endemic in India. Out of 128 million infected individuals worldwide, India accounts for 48 million cases [Manson's Tropical Diseases, 21st Ed. p 1488]. Filariasis can have protean manifestations, but Tropical pulmonary eosinophilia and chyluria are unusual manifestations reported mainly from So...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.03.002
更新日期：2007-09-01 00:00:00
abstract：:Alternative strategies are being designed to identify candidates among drugs already available on the market that could be used in combination to improve the efficacy of Chagas disease treatment. This work evaluates the effect of the association of clomipramine (CLO) with benznidazole (BZN) for the treatment of experi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.02.004
更新日期：2013-06-01 00:00:00
abstract：:Diphyllobothrium nihonkaiense [Y. Yamane, H. Kamo, G. Bylund, J.P. Wilkgren. Diphyllobothrium nihonkaiense sp. nov (Cestoda: Diphyllobothriidae)- revised identification of Japanese broad tapeworm. Shimane J Med Sci 1986;10:29-48.] and Diphyllobothrium klebanovskii [I.V. Muratov, P.S. Posokhov. Causative agent of human...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2008.09.001
更新日期：2009-03-01 00:00:00
abstract：:The composition, structure and pattern of helminth assemblages associated with the storks (Ciconiidae), ibises and spoonbills (Threskiornithidae) are poorly understood. Here we analyze the prevalence, intensity and diversity of the helminth component communities associated with the white stork Ciconia ciconia and blac...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.11.004
更新日期：2015-04-01 00:00:00
abstract：:The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA, but the excretory/secretory products released by O. viverrini (OvES) represent t...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.02.001
更新日期：2017-08-01 00:00:00
abstract：:Fasciolosis is an economically important disease of livestock caused by Fasciola hepatica, Fasciola gigantica, and aspermic Fasciola flukes. The aspermic Fasciola flukes have been discriminated morphologically from the two other species by the absence of sperm in their seminal vesicles. To date, the molecular discrimi...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.12.002
更新日期：2016-06-01 00:00:00
abstract：:Due to the increasing development of anthelmintic resistance in nematodes worldwide, it is important to search for anthelmintic compounds with new modes of action and also to investigate the possibility to combine compounds with possible synergistic effects. There might also be the chance to take advantage of the fact...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.05.006
更新日期：2013-12-01 00:00:00
abstract：:The asexual erythrocytic cycle of the protozoan parasite Plasmodium falciparum is responsible for the pathogenesis of malaria and causes the overwhelming majority of malaria deaths. Rapidly increasing parasitaemia during this 48hour cycle threatens the survival of the human host and the parasite prior to transmission ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.07.007
更新日期：2016-12-01 00:00:00
