当前位置： SCI文献检索 > PARASITOLOGY INTERNATIONAL期刊下所有文献 > Monoquaternary ammonium derivatives inhibit growth of protozoan parasites.

Monoquaternary ammonium derivatives inhibit growth of protozoan parasites.

Abstract：

:The phospholipid metabolism of Plasmodium falciparum-infected erythrocytes has been shown to be an effective pharmacological target for novel chemotherapy. Thirty-seven monoquaternary ammonium derivatives analogous to choline were screened for their potential antiprotozoal activity against P. falciparum and Leishmania braziliensis. Twenty-three compounds inhibited chloroquine resistant and sensitive P. falciparum strains with inhibitory concentrations ranging from 0.001 microM to 47 microM. Among the inhibitors were six compounds with nanomolar activity containing at least one ethyl group in the polar head and a hydrophobic alkyl chain with 10 to 14 methylene groups. Four compounds also exhibited in vitro antileishmanial properties in the micromolar range.

journal_name

Parasitol Int

journal_title

Parasitology international

authors

Bahamontes-Rosa N,Robin A,Ambrosio AR,Messias-Reason I,Beitz E,Flitsch SL,Kun JF

doi

10.1016/j.parint.2007.09.006

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

132-7

issue

2

eissn

1383-5769

issn

1873-0329

pii

S1383-5769(07)00130-4

journal_volume

57

pub_type

杂志文章

相关文献

PARASITOLOGY INTERNATIONAL文献大全
  • Phylogeny, ultrastructure and histopathology of Myxobolus lomi sp. nov., a parasite of Prochilodus lineatus (Valenciennes, 1836) (Characiformes: Prochilodontidae) from the Peixes River, São Paulo State, Brazil.

    abstract：:This paper presents the morphological, histological, molecular and ultrastructural data on Myxobolus lomi sp. nov., a parasite of the gill filaments of Prochilodus lineatus from the Peixes River (48º06'38″W; 22º 49'53.1″S), São Paulo State, Brazil. From 20 P. lineatus specimens examined, 90.0% (n=18) were infected. Th...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2013.11.008

    authors： Azevedo RK,Vieira DH,Vieira GH,Silva RJ,Matos E,Abdallah VD

    更新日期：2014-04-01 00:00:00

  • Diagnosis of the primary amoebic meningoencephalitis due to Naegleria fowleri.

    abstract：:Trophozoites of the free-living amoeba, Naegleria fowleri, were isolated from the cerebrospinal fluid of meningoencephalitis patient. The infecting agent was identified as N. fowleri based on morphologic, serologic and molecular techniques carried out on the isolated organisms. ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2005.06.001

    authors： Hara T,Fukuma T

    更新日期：2005-12-01 00:00:00

  • Morphological differences and molecular phylogenetic relationship of two tapeworm species, Moniezia expansa and Moniezia benedeni, collected from domestic ruminants in northern Vietnam.

    abstract：:Moniezia expansa and M. benedeni are two common tapeworm species of domestic ruminants over the world. However, their morphological and molecular data are available for limited specimens from a few countries. In the present study, we compared morphological characteristics of these two species collected from goats and ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2019.101998

    authors： Tam TT,Lan NTK,Doanh PN

    更新日期：2020-02-01 00:00:00

  • Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex.

    abstract：:Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K272R, Y268C...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2014.09.011

    authors： Siregar JE,Kurisu G,Kobayashi T,Matsuzaki M,Sakamoto K,Mi-ichi F,Watanabe Y,Hirai M,Matsuoka H,Syafruddin D,Marzuki S,Kita K

    更新日期：2015-06-01 00:00:00

  • Venison, another source of Paragonimus westermani infection.

    abstract：:Paragonimiasis is a typical food-borne parasitic disease, endemic in most parts of Asia, with sporadic case reports from American and African countries. The major source of infection is undercooked freshwater crab or crayfish, though consumption of wild boar meat is also responsible for the infection in Japan, because...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2016.09.009

    authors： Yoshida A,Matsuo K,Moribe J,Tanaka R,Kikuchi T,Nagayasu E,Misawa N,Maruyama H

    更新日期：2016-12-01 00:00:00

  • Visceral pentastomiasis caused by Armillifer armillatus in a captive striped hyena (Hyaena hyaena) in Chiang Mai Night Safari, Thailand.

    abstract：:Visceral pentastomiasis (porocephalosis) caused by Armillifer armillatus larvae was incidentally diagnosed in a female striped hyena (Hyaena hyaena) of unknown age which died unexpectedly in 2013. The hyena had been imported from Tanzania 8years earlier and have been since then in a zoo in Chiang Mai, northern Thailan...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2015.10.004

    authors： Dechkajorn S,Nomsiri R,Boonsri K,Sripakdee D,Sukontason KL,Wannasan A,Chailangkarn S,Tiwananthagorn S

    更新日期：2016-02-01 00:00:00

  • First record and analysis of the COI gene of Cobboldia elephantis obtained from a captive Asian elephant from Myanmar.

    abstract：:The stomach bot fly species in Asian elephants has long been known as Cobboldia elephantis. However, there is no genetic information available for this species to date. Here, we report that a third-instar fly larva was excreted from a captive Asian elephant four months after export from an elephant camp in Myanmar to ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2019.102035

    authors： Chel HM,Nakao R,Ohsawa N,Oo ZM,Nonaka N,Katakura K

    更新日期：2020-04-01 00:00:00

  • Multiple-subgenotype infections of Giardia intestinalis detected in Palestinian clinical cases using a subcloning approach.

    abstract：:To evaluate the geographic distribution of Giardia intestinalis genotypes in Nablus, West Bank, Palestine, a genotyping study was performed using clinical fecal samples. Microscopic examination confirmed that 8 of 69 (11.6%) samples were G. intestinalis positive, and subsequent genotyping analyses targeting the small-...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2009.04.002

    authors： Hussein AI,Yamaguchi T,Nakamoto K,Iseki M,Tokoro M

    更新日期：2009-09-01 00:00:00

  • First molecular evidence of ocular transmission of Encephalitozoonosis during the intrauterine period in rabbits.

    abstract：:Many reports have been published on the suspected vertical transmission of Encephalitozoon cuniculi; however, prior to 2003, these reports were based on circumstantial evidence, such as histopathological, immunohistochemical, or serological diagnosis of the infection. In 2003, vertical transmission of the parasite was...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2019.03.006

    authors： Ozkan O,Karagoz A,Kocak N

    更新日期：2019-08-01 00:00:00

  • Molecular analysis of tick-borne protozoan and rickettsial pathogens in small ruminants from two South African provinces.

    abstract：:Tick-borne protozoan and rickettsial diseases are a major threat to livestock in tropical and sub-tropical regions of Africa. In this study we investigated the presence and distribution of Theileria spp., Babesia ovis, Anaplasma ovis, Anaplasma phagocytophilum, Ehrlichia ruminantium and SFG Rickettsia in sheep and goa...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2017.11.002

    authors： Ringo AE,Adjou Moumouni PF,Taioe M,Jirapattharasate C,Liu M,Wang G,Gao Y,Guo H,Lee SH,Zheng W,Efstratiou A,Li J,Inoue N,Suzuki H,Thekisoe O,Xuan X

    更新日期：2018-04-01 00:00:00

  • Ascaridoid parasites infecting in the frequently consumed marine fishes in the coastal area of China: A preliminary investigation.

    abstract：:Marine fishes represent the important components of the diet in the coastal areas of China and they are also natural hosts of various parasites. However, to date, little is known about the occurrence of ascaridoid parasites in the frequently consumed marine fishes in China. In order to determine the presence of ascari...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2015.11.002

    authors： Zhao WT,Lü L,Chen HX,Yang Y,Zhang LP,Li L

    更新日期：2016-04-01 00:00:00

  • Larva migrans in squirrel monkeys experimentally infected with Baylisascaris potosis.

    abstract：:Roundworms of the genus Baylisascaris are natural parasites primarily of wild carnivores, and they can occasionally cause infection in humans and animals. Infection results in visceral larva migrans and/or neural larva migrans, which can be severe or fatal in some animals. Recently, Baylisascaris nematodes isolated fr...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2015.03.003

    authors： Tokiwa T,Tsugo K,Nakamura S,Taira K,Une Y

    更新日期：2015-10-01 00:00:00

  • Development of a PCR-RFLP marker to genetically distinguish Prosorhynchus crucibulum and Prosorhynchus aculeatus.

    abstract：:The cercariae stages of Prosorhynchus crucibulum and Prosorhynchus aculeatus are morphologically indistinguishable. However, the differentiation of these two species is crucial to understand the transmission dynamics between these primary hosts (mussels) and the secondary hosts (fish). In this way, the objective of th...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2009.09.004

    authors： Francisco CJ,Almeida A,Castro AM,Santos MJ

    更新日期：2010-03-01 00:00:00

  • Chyluria with proteinuria or filarial nephropathy? An enigma.

    abstract：:Lymphatic filariasis is endemic in India. Out of 128 million infected individuals worldwide, India accounts for 48 million cases [Manson's Tropical Diseases, 21st Ed. p 1488]. Filariasis can have protean manifestations, but Tropical pulmonary eosinophilia and chyluria are unusual manifestations reported mainly from So...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2007.03.002

    authors： Gulati S,Gupta N,Singh NP,Batra S,Garg S,Beniwal P,Kumar S

    更新日期：2007-09-01 00:00:00

  • Novel methods for the molecular discrimination of Fasciola spp. on the basis of nuclear protein-coding genes.

    abstract：:Fasciolosis is an economically important disease of livestock caused by Fasciola hepatica, Fasciola gigantica, and aspermic Fasciola flukes. The aspermic Fasciola flukes have been discriminated morphologically from the two other species by the absence of sperm in their seminal vesicles. To date, the molecular discrimi...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2015.12.002

    authors： Shoriki T,Ichikawa-Seki M,Suganuma K,Naito I,Hayashi K,Nakao M,Aita J,Mohanta UK,Inoue N,Murakami K,Itagaki T

    更新日期：2016-06-01 00:00:00

  • Adenovirus-mediated over-expression of Septin4 ameliorates hepatic fibrosis in mouse livers infected with Schistosoma japonicum.

    abstract：:Septin4 (Sept4) belongs to Septin family and may be involved in apoptosis, vesicle trafficking and other cell processes. In this study, we attempted to investigate the effect of Sept4 in hepatic fibrosis induced by Schistosoma japonicum. ICR mice infected with S. japonicum for 12weeks were treated with PBS, Ad-ctr and...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2015.07.002

    authors： He X,Bao J,Chen J,Sun X,Wang J,Zhu D,Song K,Peng W,Xu T,Duan Y

    更新日期：2015-12-01 00:00:00

  • Diversity of sea lice (Copepoda: Caligidae) parasitic on marine fishes with commercial and aquaculture importance in Chamela Bay, Pacific coast of Mexico by using morphology and DNA barcoding, with description of a new species of Caligus.

    abstract：:The occurrence of parasitic copepods of the family Caligidae on wild and cultured marine fishes from Chamela Bay, on the Pacific coast of Mexico, is reported. A total of 16 species of Caligus and 1 species of Lepeophtheirus were found on 19 wild fish species. The description of Caligus chamelensis n. sp. parasitizing ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2013.09.005

    authors： Morales-Serna FN,Pinacho-Pinacho CD,Gómez S,de León GP

    更新日期：2014-02-01 00:00:00

  • First epidemiological study on exposure to Neospora caninum in different canine populations in the Algiers District (Algeria).

    abstract：:Neospora caninum is an important cause of abortion in cattle worldwide. Dogs act as final hosts shedding oocysts in the environment. They can also harbour the extraintestinal stage of the parasite and this may be associated with a fairly rare neuromuscular condition. The sera of 781 dogs from the Algiers District were...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2009.08.008

    authors： Ghalmi F,China B,Kaidi R,Losson B

    更新日期：2009-12-01 00:00:00

  • A set of serine proteinase paralogs are required for blood-digestion in the ixodid tick Haemaphysalis longicornis.

    abstract：:We present evidence demonstrating that genes encoding enzymes essential for successful blood-feeding are differentially induced in the midgut of the hard tick Haemaphysalis longicornis. Three serine proteinase genes (HlSP, HlSP2 and HlSP3) isolated from H. longicornis midgut exhibit protein sequence similarity with ot...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2008.08.003

    authors： Miyoshi T,Tsuji N,Islam MK,Alim MA,Hatta T,Huang X,Fujisaki K

    更新日期：2008-12-01 00:00:00

  • Mitochondrial DNA divergence in populations of the tapeworm Diphyllobothrium nihonkaiense and its phylogenetic relationship with Diphyllobothrium klebanovskii.

    abstract：:Diphyllobothrium nihonkaiense [Y. Yamane, H. Kamo, G. Bylund, J.P. Wilkgren. Diphyllobothrium nihonkaiense sp. nov (Cestoda: Diphyllobothriidae)- revised identification of Japanese broad tapeworm. Shimane J Med Sci 1986;10:29-48.] and Diphyllobothrium klebanovskii [I.V. Muratov, P.S. Posokhov. Causative agent of human...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2008.09.001

    authors： Arizono N,Shedko M,Yamada M,Uchikawa R,Tegoshi T,Takeda K,Hashimoto K

    更新日期：2009-03-01 00:00:00

  • Schistosomiasis in Indonesia: past and present.

    abstract：:Schistosomiasis is endemic in Indonesia in two isolated areas, Lindu valley and Napu valley, both located in the Province of Central Sulawesi. In 1940, a prevalence survey was initiated in Lake Lindu, which indicated a Schistosoma japonicum infection prevalence of 56% among the population of Anca, Tomado and Langko vi...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2008.04.008

    authors： Garjito TA,Sudomo M,Abdullah,Dahlan M,Nurwidayati A

    更新日期：2008-09-01 00:00:00

  • Insights into the mode of action of 1,2,6,7-tetraoxaspiro [7.11] nonadecane (N-89) against adult Schistosoma mansoni worms.

    abstract：:Control of morbidity associated with schistosomiasis via chemotherapy largely relies on the drug praziquantel. Repeated therapy with praziquantel has created concerns about the possible selection of resistant worms and necessitated the search for novel drugs to treat schistosomiasis. Here, a murine model was infected ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2018.03.006

    authors： Blay EA,Kumagai T,Yamabe M,Hino A,Shimogawara R,Kim HS,Sato A,Ichimura K,Ayi I,Iwanaga S,Ohta N

    更新日期：2018-08-01 00:00:00

  • Involvement of STI1 protein in the differentiation process of Trypanosoma cruzi.

    abstract：:The protozoan Trypanosoma cruzi is a parasite exposed to several environmental stressors inside its invertebrate and vertebrate hosts. Although stress conditions are involved in its differentiation processes, little information is available about the stress response proteins engaged in these activities. This work repo...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2017.10.009

    authors： Schmidt JC,Manhães L,Fragoso SP,Pavoni DP,Krieger MA

    更新日期：2018-04-01 00:00:00

  • Observations on clinical efficacy of albendazole emulsion in 264 cases of hepatic cystic echinococcosis.

    abstract：:Two regimens of albendazole emulsion (AbzE), a novel formulation, were used in the treatment of 264 cases of hepatic cystic echinococcosis. AbzE 10 mg/kg per day (calculated by albendazole base) was administered orally to 71 cases for 6 months to over 1 year. Imaging evaluation at the end of courses showed overall eff...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2003.09.015

    authors： Chai J,Menghebat,Wei J,Deyu S,Bin L,Jincao S,Chen F,Xiong L,Yiding M,Xiuling W,Dolikun,Guliber,Yanchun W,Fanghua G,Shuhua X

    更新日期：2004-03-01 00:00:00

  • Sex chromosome differences among the three races (alpha, beta, gamma) of the snail intermediate host of Schistosoma mekongi, Neotricula aperta.

    abstract：:Chromosome analyses were performed on three races (alpha, beta, gamma) of Neotricula aperta which were previously reported to show variation in the chromosome number and pairing in meiosis. We used an air-drying method, which was more reliable for chromosome preparations from fresh animal tissues than a squash method....

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/s1383-5769(00)00053-2

    authors： Taguchi T,Hirai H,Upatham S,Agatsuma T

    更新日期：2000-12-01 00:00:00

  • Use of a recombinant Clonorchis sinensis pore-forming peptide, clonorin, for serological diagnosis of clonorchiasis.

    abstract：:A recombinant pore-forming peptide of Clonorchis sinensis, clonorin, was evaluated for serodiagnostic reagent of clonorchiasis by enzyme-linked immunosorbent assay detecting IgG antibody. Recombinant clonorin showed 100% specificity and low sensitivity for sera of human clonorchiasis. In contrast, C. sinensis crude an...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/s1383-5769(03)00002-3

    authors： Lee JY,Kim TY,Gan XX,Kang SY,Hong SJ

    更新日期：2003-06-01 00:00:00

  • Analysis of phosphorylated proteins and inhibition of kinase activity during Giardia intestinalis excystation.

    abstract：:The parasite Giardia intestinalis undergoes a differentiation process that allows it to infect its mammal host. That process is excystation. We examined the importance of protein phosphorylation during the passage from cyst to trophozoite. Cysts obtained from patients with giardiasis were excysted in vitro and the sol...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2009.10.005

    authors： Alvarado ME,Wasserman M

    更新日期：2010-03-01 00:00:00

  • Seroprevalence of Toxoplasma gondii infection in cattle, horses, pigs and chickens in Japan.

    abstract：:The presence of antibodies to Toxoplasma gondii in livestock and poultry was investigated by latex agglutination tests; samples that agglutinated at dilutions of 1:64 or higher were regarded as positive. Sera were collected from fattening beef cattle (102 Japanese black, 105 crossbreeds and 114 castrated Holstein), cu...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2014.04.003

    authors： Matsuo K,Kamai R,Uetsu H,Goto H,Takashima Y,Nagamune K

    更新日期：2014-08-01 00:00:00

  • Parasitological and biochemical parameters in Schistosoma mansoni-infected mice treated with methanol extract from the plants Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban.

    abstract：:This study aims to detect the antischistosomal properties of the plants' Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban methanol extract against Schistosoma mansoni in infected mice, including determination of total protein and albumin levels and the activities of alanine and aspartate transaminases ...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2011.06.016

    authors： Kamel EG,El-Emam MA,Mahmoud SS,Fouda FM,Bayaumy FE

    更新日期：2011-12-01 00:00:00

  • First molecular detection of Mycoplasma wenyonii and the ectoparasite biodiversity in dairy water buffalo and cattle in Bohol, Philippines.

    abstract：:Hemoplasmosis caused by Mycoplasma spp. have been associated with major economic losses in the global dairy production. Hemoplasma studies in the Philippines are limited despite its potential impact. This study mainly aimed to detect the presence of hemoplasma species in dairy water buffaloes and cattle and know their...

    journal_title：Parasitology international

    pub_type： 杂志文章

    doi：10.1016/j.parint.2019.02.004

    authors： Ybañez AP,Ybañez RHD,Armonia RKM,Chico JKE,Ferraren KJV,Tapdasan EP,Salces CB,Maurillo BCA,Galon EMS,Macalanda AMC,Moumouni PFA,Xuan X

    更新日期：2019-06-01 00:00:00