Abstract:
:Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternatives such as the use of traditional medicinal plants has been increased. The aim of the current experimental work was to investigate the chemoprophylactic and clinical efficacy of thymol on mice infected with E. granulosus metacestodes. Thymol (40 mg/kg) was administered under two different therapeutic schemes: dosing every 24h over 20 days and treatment every 12h for 10 days. Thymol demonstrated efficacy against experimental murine cystic echinococcosis. The chemoprophylactic and therapeutic effects of thymol were comparable to that of albendazole. Due to the lack of toxicity observed in mice at the tested doses; we consider that thymol is a potential alternative to be applied for the treatment of human hydatid disease.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Maggiore M,Pensel PE,Denegri G,Elissondo MCdoi
10.1016/j.parint.2015.06.005subject
Has Abstractpub_date
2015-10-01 00:00:00pages
435-40issue
5eissn
1383-5769issn
1873-0329pii
S1383-5769(15)00102-6journal_volume
64pub_type
杂志文章abstract::Intestinal mucous cell numbers and their glycoconjugate composition were investigated by histochemical methods in uninfected chub, Squalius cephalus, and in conspecifics naturally parasitised with the acanthocephalan Pomphorhynchus laevis. A sub-population of 42 chub from the River Tiber (Perugia, Italy) were sampled ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2014.11.018
更新日期:2015-04-01 00:00:00
abstract::The salmon louse (Lepeophtheirus salmonis (Krøyer 1837)) is an ectoparasitic copepod which represents a major pathogen of wild and farmed salmonid fishes in the marine environment. In order to facilitate research on this ecologically and economically important parasite, a hatchery and culturing system permitting the c...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.08.009
更新日期:2009-12-01 00:00:00
abstract::Paragonimiasis is a typical food-borne parasitic disease, endemic in most parts of Asia, with sporadic case reports from American and African countries. The major source of infection is undercooked freshwater crab or crayfish, though consumption of wild boar meat is also responsible for the infection in Japan, because...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2016.09.009
更新日期:2016-12-01 00:00:00
abstract::Larval infection with Echinococcus multilocularis starts with the intrahepatic postoncospheral development of a metacestode that-at its mature stage-consists of an inner germinal and an outer laminated layer (GL & LL). In certain cases, an appropriate host immune response may inhibit parasite proliferation. Several li...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2005.11.006
更新日期:2006-01-01 00:00:00
abstract::Although there is a great diversity of techniques and antigens used in the serodiagnosis of canine visceral leishmaniasis (CVL), total sensitivity and specificity have not yet been found. Since the use of amastigote forms in the indirect immunofluorescence assay has shown an improvement in the specificity of the test ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102177
更新日期:2020-12-01 00:00:00
abstract::Three hundred and forty-nine autopsy cases of schistosomiasis japonica were divided into two groups, based on the pathomorphology. Frequent regressive hepatic lesions such as active schistosomal lesion and destruction of limiting plates characterized the first group. The second group showed reparative hepatic lesions ...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2003.09.004
更新日期:2003-12-01 00:00:00
abstract::Extralymphatic filariasis is an uncommon phenomenon that can be caused by several lymphatic filarial species, including zoonotic filaria of animal origins. In this study, we report a case of a 64-year-old Thai woman who presented with a lump in her left breast that was diagnosed with invasive ductal carcinoma. At the ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102203
更新日期:2021-02-01 00:00:00
abstract::Malaria is one of the most debilitating and life threatening diseases in tropical regions of the world. Over 500 million clinical cases occur, and 2-3 million people die of the disease each year. Because Plasmodium lacks genuine glutathione peroxidase and catalase, the two major antioxidant enzymes in the eukaryotic c...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2007.08.001
更新日期:2008-03-01 00:00:00
abstract::Cardicola ambrosioi n. sp. (Digenea: Sanguinicolidae) is found in the blood vessels of liver and gills of the Brazilian flathead, Percophis brasiliensis Quoy and Gaimard, 1824 (Pisces: Percophidae), from Mar del Plata, Argentina. Among the 13 known species within Cardicola Short, 1953, the new species closely resemble...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2006.03.002
更新日期:2006-09-01 00:00:00
abstract::The studies on Cryptosporidium infections of animals in Turkey mostly rely on microscopic observation. Few data are available regarding the prevalence of Cryptosporidium genotypes and subtypes infection. The aim of this study is to analyse the detection of Cryptosporidium genotypes and subtypes from young ruminants. A...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102163
更新日期:2020-12-01 00:00:00
abstract::The present work provides a detailed morphological and molecular description of Anoplocephala manubriata in elephants. Adult worms were recovered during an autopsy of a wild elephant in Elephant Transit Home, Udawalawe, Sri Lanka. Necropsy findings revealed a severe cestode infection in the small intestine. These tape...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.02.007
更新日期:2017-06-01 00:00:00
abstract::Hydroethidine has been used as a viability dye in various haemoparasites, including Plasmodium species. We compared flow cytometric quantification by hydroethidine and thiazole orange in P. falciparum. Dead parasites that did not develop or replicate exhibited high levels of DNA fragmentation and abnormal microscopic ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2012.07.002
更新日期:2012-12-01 00:00:00
abstract::Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro par...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.01.017
更新日期:2017-06-01 00:00:00
abstract::The largest subunit of eukaryotic RNA polymerase II (RNA Pol II) of several members of Kinetoplastida order and other early diverging eukaryote contains a serine, tyrosine and proline-rich domain in the carboxyl-terminal instead of the typical heptapeptides repeats found in most eukaryotes. The lack of these repeats s...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(03)00009-6
更新日期:2003-09-01 00:00:00
abstract::European liver fluke (Opisthorchis felineus) and Asian liver fluke (Opisthorchis viverrini) are similar in morphology but comparative pathology of the infections has not been described. We therefore did comparative histopathology of both parasites in an experimental animal model. The study was conducted in 3 groups of...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2011.08.005
更新日期:2012-03-01 00:00:00
abstract::Cysticercosis caused by infection with embryonated eggs of the pork tapeworm Taenia solium is an important cause of neurological disease worldwide. Based on the phylogenetic analysis of mitochondrial DNA, the pathogen has been divided into two geographic clades, corresponding to Afro-American and Asian genotypes. In t...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2010.11.004
更新日期:2011-01-01 00:00:00
abstract::Strongyloides stercoralis is a parasitic nematode and a major pathogen responsible for human strongyloidiasis. The presence of this species in the dog population has led to an interest in studying the phylogenetic relationships among Strongyloides spp. in carnivore hosts. In the present study, Strongyloides spp. from ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102151
更新日期:2020-10-01 00:00:00
abstract::A schistosome genome project was initiated by the World Health Organization in 1994 with the notion that the best prospects for identifying new targets for drugs, vaccines, and diagnostic development lie in schistosome gene discovery, development of chromosome maps, whole genome sequencing and genome analysis. Schisto...
journal_title:Parasitology international
pub_type: 杂志文章,评审
doi:10.1016/j.parint.2004.01.009
更新日期:2004-06-01 00:00:00
abstract::Pinworm parasites commonly infect laboratory mice with high prevalence even in well-managed animal colonies. Although often considered as irrelevant, these parasites if undetected may significantly interfere with the experimental settings and alter the interpretation of final results. There are a few reports documenti...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2005.10.005
更新日期:2006-06-01 00:00:00
abstract::Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg tablets in many of the endemic countries, is currently the drug of choice for the specific treatment...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2012.09.001
更新日期:2013-02-01 00:00:00
abstract::The parasite Entamoeba histolytica causes intestinal amebiasis and amebic liver abscess as its main extraintestinal manifestation. To study the in vivo events related to inflammation and the interactions between hosts and parasites during amebiasis, we designed a novel model of host-parasite interactions using cellulo...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2016.08.009
更新日期:2016-12-01 00:00:00
abstract::Dientamoeba fragilis is an intestinal protozoan, an inhabitant of the human gastrointestinal tract, with a worldwide distribution. The reported prevalence of D. fragilis varies worldwide in different populations between 0.3% and 82.9%, and its role as a pathogen is still unclear. The parasite has been identified in th...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102227
更新日期:2021-02-01 00:00:00
abstract::Muscular sarcocystosis by Sarcocystis arctica was found for the first time in the Czech Republic, in different muscles of red fox (Vulpes vulpes). Cysts were slim, elongated, thread-like, whitish, 1-7mm long, and 206-270μm wide; bradyzoites were 7.9×2.7μm in unstained wet mounts and 9.2×2.9μm in cyst Giemsa-stained sm...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2017.05.003
更新日期:2017-10-01 00:00:00
abstract::The parasite Giardia intestinalis undergoes a differentiation process that allows it to infect its mammal host. That process is excystation. We examined the importance of protein phosphorylation during the passage from cyst to trophozoite. Cysts obtained from patients with giardiasis were excysted in vitro and the sol...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.10.005
更新日期:2010-03-01 00:00:00
abstract::Miamiensis avidus causes scuticociliatosis in cultured olive flounders (Paralichthys olivaceus), leading to economic losses in aquaculture in Korea. Quantitative evaluation of the viability of M. avidus is important to develop an effective vaccine or chemotherapeutic agent against it. We used a colorimetric assay base...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2020.102093
更新日期:2020-06-01 00:00:00
abstract::Immunodeficient mice were studied to determine their suitability as models in investigating the role of Taenia taeniaeformis larval products in the development of gastric hyperplasia. Recombinant active gene 2 (RAG2)-deficient and severe combined immune-deficient (SCID) mice were studied as candidate animal models. RA...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(01)00108-8
更新日期:2002-03-01 00:00:00
abstract::It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites. Furthermore, the N-terminal recombinant SER...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(00)00040-4
更新日期:2000-08-01 00:00:00
abstract::We report here the molecular characterization and possible function of a cysteine protease (termed HlCPL-A) identified in the midgut of the hard tick Haemaphysalis longicornis. HlCPL-A is a 333 amino acid protein belonging to the papain family of the cysteine protease. A construct encoding proHlCPL-A was expressed in ...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/j.parint.2009.05.003
更新日期:2009-09-01 00:00:00
abstract::There is limited knowledge about parasites of the endangered Ryukyu long-furred rat, Diplothrix legata (Murinae, Rodentia) endemic to Okinawa, Tokunoshima, and Amami-Oshima Islands in Japan. In the present study, postmortem histopathological examination of an individual found on Amami-Oshima Island revealed a mixed he...
journal_title:Parasitology international
pub_type:
doi:10.1016/j.parint.2020.102058
更新日期:2020-06-01 00:00:00
abstract::The raccoon dog (Nyctereutes procyonoides viverrinus) is known to acquire canine heartworm (Dirofilaria immitis) infection. We surveyed the prevalence of heartworm infection in free-ranging raccoon dogs in the Nishi-Tama (Tokyo) and Kanagawa areas of Japan. A total of 75 raccoon dog carcasses, including 29 animals fro...
journal_title:Parasitology international
pub_type: 杂志文章
doi:10.1016/s1383-5769(00)00049-0
更新日期:2000-09-01 00:00:00