Abstract：
:It has been reported that serine repeat antigen (SERA) binds directly to human erythrocyte membranes, inside-out vesicles and intact mouse erythrocytes. Similarly, mAbs specific against SERA are effective in blocking red blood cell (RBC) invasion by P. falciparum merozoites. Furthermore, the N-terminal recombinant SERA fragment inhibits the merozoite invasion of erythrocyte. In this study of 49 non-overlapping 20-residue-long peptides encompassing the whole SERA protein FCR3 strain, seven peptides having high RBC binding activity were found. Six of these peptides (three from the SERA N-terminal domain) are located in conserved regions and show affinity constants between 150 and 1100 nM, Hill coefficients between 1.5 and 3.0 and 30000-120000 binding sites per cell. Some of these peptides inhibited in vitro merozoite invasion of erythrocyte and intra-erythrocytic development. Residues which are critical in the binding to erythrocytes (in bold face), i.e. 6725 (YLKETNNAISFESNSGSLEKK), 6733 (YALGSDIPEKCDTLASNCFLS), 6737 (YDNILVKMFKTNENNDKSELI), 6746 (DQGNCDTSWIFASKYHLETI), 6754 (YKKVQNLCGDDTADHAVNIVG) and 6762 (NEVSERVHVYHILKHIKDGK), were determined by means of competition assays with high-binding peptide glycine analogues. The identification of peptides which bind to erythrocyte membrane is important in understanding the process of RBC invasion by P. falciparum merozoites.
journal_name
Parasitol Intjournal_title
Parasitology internationalauthors
Puentes A,Garcia J,Vera R,Lopez QR,Urquiza M,Vanegas M,Salazar LM,Patarroyo MEdoi
10.1016/s1383-5769(00)00040-4subject
Has Abstractpub_date
2000-08-01 00:00:00pages
105-17issue
2eissn
1383-5769issn
1873-0329pii
S1383576900000404journal_volume
49pub_type
杂志文章abstract：:The phospholipid metabolism of Plasmodium falciparum-infected erythrocytes has been shown to be an effective pharmacological target for novel chemotherapy. Thirty-seven monoquaternary ammonium derivatives analogous to choline were screened for their potential antiprotozoal activity against P. falciparum and Leishmania...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.09.006
更新日期：2008-06-01 00:00:00
abstract：:Dioctophymosis is the disease caused by the nematode Dioctophyme renale, normally found parasitizing the right kidney of dogs. The absence of symptoms is frequent in parasitized animals. The surgical procedures are commonly performed to treat this disease. This work describes a case involving a canine with renal and e...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2020.102211
更新日期：2021-02-01 00:00:00
abstract：:Owing to the need to combat the spread of acaricide-resistant ticks, the development of long-term biological control has become a hot topic for tick control. In this study, we investigated the pathogenicity of three Beauveria bassiana isolates on the engorged female Rhipicephalus (Boophilus) microplus ticks using diff...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.04.008
更新日期：2013-10-01 00:00:00
abstract：:Granuloma modulation induced by antigen is an attractive model for vaccination studies of experimental schistosomiasis to test the effect of anti-pathology vaccine. We describe here an immunization procedure with culture derived macrophages-pulsed PIII, a known anionic antigen purified from S. mansoni adult worm, invo...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(02)00031-4
更新日期：2002-09-01 00:00:00
abstract：:"Below is an essay by Prof. Tanabe originally written in Japanese. It gives an insight to Prof. Tanabe's inquiring mind and his approach to science. He also seek, as always, to inspire and nudge the young to scientific discovery". ...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2014.11.010
更新日期：2015-06-01 00:00:00
abstract：:The protozoan Trypanosoma cruzi is a parasite exposed to several environmental stressors inside its invertebrate and vertebrate hosts. Although stress conditions are involved in its differentiation processes, little information is available about the stress response proteins engaged in these activities. This work repo...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.10.009
更新日期：2018-04-01 00:00:00
abstract：:Neospora caninum is an intracellular protozoan that infects many domestic and wild animals. Domestic dogs and other canids function as definitive hosts, while other mammals serve as natural intermediate hosts. In the present study, the brain tissues of bats collected in Yunnan Province, Southern China were tested by N...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.03.002
更新日期：2018-08-01 00:00:00
abstract：:Strongyloides venezuelensis is one of some 50 species of genus Strongyloides, obligate gastrointestinal parasites of vertebrates, responsible for strongyloidiasis in humans and other domestic/companion animals. Although S. venezuelensis has been widely used as a model species for studying human/animal strongyloidiasis...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2012.09.006
更新日期：2013-02-01 00:00:00
abstract：:Paragonimiasis is a typical food-borne parasitic disease, endemic in most parts of Asia, with sporadic case reports from American and African countries. The major source of infection is undercooked freshwater crab or crayfish, though consumption of wild boar meat is also responsible for the infection in Japan, because...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：:This study aims to detect the antischistosomal properties of the plants' Chenopodium ambrosioides, Conyza dioscorides and Sesbania sesban methanol extract against Schistosoma mansoni in infected mice, including determination of total protein and albumin levels and the activities of alanine and aspartate transaminases ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.06.016
更新日期：2011-12-01 00:00:00
abstract：:Host-parasite interaction during infection with the liver fluke Opisthorchis viverrini plays an important role in opisthorchiasis-associated cholangiocarcinoma via nitric oxide (NO) production. Host cells induce nitric oxide synthase (NOS)-dependent DNA damage and secrete Ras-related C3 botulinum toxin substrate (Rac)...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.06.017
更新日期：2012-03-01 00:00:00
abstract：:Individuals living in malaria endemic areas become clinically immune after multiple re-infections over time and remain infected without apparent symptoms. However, it is unclear why a long period is required to gain clinical immunity to malaria, and how such immunity is maintained. Although malaria infection is report...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2018.01.001
更新日期：2018-06-01 00:00:00
abstract：:Taenia tapeworms of Finnish and Swedish wolves (Canis lupus) and Finnish brown bears (Ursus arctos), and muscle cysticerci of Svalbard reindeer (Rangifer tarandus platyrhynchus), Alaskan Grant's caribou (Rangifer tarandus granti) and Alaskan moose (Alces americanus) were identified on the basis of the nucleotide seque...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2011.04.004
更新日期：2011-09-01 00:00:00
abstract：:To assess the epidemiological efficacy of type SRP III slow-released praziquantel-medicated bars for dogs in the prevention and control of cystic echinococcosis in man and livestock, praziquantel-medicated bars were implanted subcutaneously in over 90% of dogs in villages in north Xinjiang, China, where cystic echinoc...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2005.06.002
更新日期：2005-12-01 00:00:00
abstract：:The raccoon dog (Nyctereutes procyonoides viverrinus) is known to acquire canine heartworm (Dirofilaria immitis) infection. We surveyed the prevalence of heartworm infection in free-ranging raccoon dogs in the Nishi-Tama (Tokyo) and Kanagawa areas of Japan. A total of 75 raccoon dog carcasses, including 29 animals fro...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00049-0
更新日期：2000-09-01 00:00:00
abstract：:Brasicystis bennetti Thatcher, 1979 was first described from specimens obtained from the subcutaneous tissues of the mouth and operculum of Plagioscyion squamosissimus from the Amazon River in Brazil, however since 2008, Brasicystis has been considered a genus inquirendum. This study reviews some of the diagnostic cha...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2013.01.001
更新日期：2013-04-01 00:00:00
abstract：:Visceral Leishmaniasis (VL), caused by Leishmania donovani is endemic in the Indian sub-continent. Mannose-binding Lectin (MBL) is a complement lectin protein that binds to the surface of Leishmania promastigotes and results in activation of the complement lectin cascade. We utilized samples of 218 VL patients and 215...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2015.08.003
更新日期：2015-12-01 00:00:00
abstract：:We report here the molecular characterization and possible function of a cysteine protease (termed HlCPL-A) identified in the midgut of the hard tick Haemaphysalis longicornis. HlCPL-A is a 333 amino acid protein belonging to the papain family of the cysteine protease. A construct encoding proHlCPL-A was expressed in ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.05.003
更新日期：2009-09-01 00:00:00
abstract：:The var genes encode a family of adhesion receptor proteins, Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which profoundly influence malaria pathogenesis. Only a single var gene is transcribed and one PfEMP1 expressed per P.falciparum parasite. Here we present the in vivo transcript distribution of v...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2009.07.004
更新日期：2009-12-01 00:00:00
abstract：:Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro par...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2017.01.017
更新日期：2017-06-01 00:00:00
abstract：:Helminths are able to modulate and suppress the hosts' immune response in order to promote their own survival. This ability to alter immune responses could be of potential detriment to the host if it interferes with the development of protective immune responses against other infections. However, helminth infections h...
journal_title：Parasitology international
pub_type： 杂志文章,评审
doi：10.1016/j.parint.2009.02.001
更新日期：2009-06-01 00:00:00
abstract：:In the early stage of research on Clonorchis and clonorchiasis, Japanese parasitologists made a tremendous contribution on the elucidation of the life cycle of this parasite and on the epidemiology of the disease. Harujiro Kobayashi first identified cyprinoid fish as the second intermediate hosts for Clonorchis sinens...
journal_title：Parasitology international
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.parint.2011.06.003
更新日期：2012-03-01 00:00:00
abstract：:Eosinophilic meningitis caused by Angiostrongylus cantonensis is a zoonosis endemic to Southeast Asia and the Pacific islands. It is considered an emerging disease because it has been expanding both geographically and in terms of the range of hosts. In South America, the first cases were reported in Brazil and were at...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.04.008
更新日期：2014-08-01 00:00:00
abstract：:The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA, but the excretory/secretory products released by O. viverrini (OvES) represent t...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2016.02.001
更新日期：2017-08-01 00:00:00
abstract：:Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) expressed on the surface of parasitized red blood cells (PRBCs) mediate adhesion of PRBCs to host vascular endothelial receptors and is considered responsible for pathogenesis of severe P. falciparum malaria. The present study was undertaken to measure cell...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2006.11.003
更新日期：2007-03-01 00:00:00
abstract：:Lymphatic filariasis is endemic in India. Out of 128 million infected individuals worldwide, India accounts for 48 million cases [Manson's Tropical Diseases, 21st Ed. p 1488]. Filariasis can have protean manifestations, but Tropical pulmonary eosinophilia and chyluria are unusual manifestations reported mainly from So...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2007.03.002
更新日期：2007-09-01 00:00:00
abstract：:The life cycle of Coitocoecum plagiorchis Ozaki, 1926 (Coitocaecum is an incorrect subsequent spelling) was studied in the field and laboratory. The study was conducted at the Futatsu River and the Chikugo River, Kyushu, Japan. Adults of C. plagiorchis were obtained from fishes Coreoperca kawamebari, Rhinogobius spp. ...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2005.06.004
更新日期：2005-12-01 00:00:00
abstract：:The presence of antibodies to Toxoplasma gondii in livestock and poultry was investigated by latex agglutination tests; samples that agglutinated at dilutions of 1:64 or higher were regarded as positive. Sera were collected from fattening beef cattle (102 Japanese black, 105 crossbreeds and 114 castrated Holstein), cu...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2014.04.003
更新日期：2014-08-01 00:00:00
abstract：:Chromosome analyses were performed on three races (alpha, beta, gamma) of Neotricula aperta which were previously reported to show variation in the chromosome number and pairing in meiosis. We used an air-drying method, which was more reliable for chromosome preparations from fresh animal tissues than a squash method....
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/s1383-5769(00)00053-2
更新日期：2000-12-01 00:00:00
abstract：:Gastrointestinal parasites including Eimeria spp. are known to affect domestic animal productivity causing watery or lethal bloody diarrhea. However, there are few reports on the detailed distribution of bovine Eimeria spp. in cattle, particularly in developing tropical and sub-tropical areas. Using a total of 289 fec...
journal_title：Parasitology international
pub_type： 杂志文章
doi：10.1016/j.parint.2019.101927
更新日期：2019-10-01 00:00:00
